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Isolation of a Cancer-Associated Microchromosome in the Sperm-Dependent Parthenogen Poecilia formosa
Please always quote using this URN: urn:nbn:de:bvb:20-opus-196785
- In the asexual all-female fish species Poecilia formosa, the Amazon molly, supernumerary chromosomes have frequently been found in both laboratory-reared and wild-caught individuals. While wild-caught individuals with B chromosomes are phenotypically indifferent from conspecifics, individuals carrying B chromosomes from recent introgression events in the laboratory show phenotypic changes. Former analyses showed that the expression of a pigment cell locus is associated with the presence of these B chromosomes. In addition, they contain a so farIn the asexual all-female fish species Poecilia formosa, the Amazon molly, supernumerary chromosomes have frequently been found in both laboratory-reared and wild-caught individuals. While wild-caught individuals with B chromosomes are phenotypically indifferent from conspecifics, individuals carrying B chromosomes from recent introgression events in the laboratory show phenotypic changes. Former analyses showed that the expression of a pigment cell locus is associated with the presence of these B chromosomes. In addition, they contain a so far unidentified locus that confers a higher susceptibility to tumor formation in the presence of pigmentation pattern. Isolation by microdissection and hybridization to metaphase chromosomes revealed that they contain one or several sequences with similarity to a highly repetitive pericentromeric and subtelomeric sequence in A chromosomes. Isolation of one particular sequence by AFLP showed that the B chromosomes contain at least 1 copy of an A-chromosomal region which is highly conserved in the whole genus Poecilia, i.e. more than 5 million years old. We propose it to be a single copy sequence.…
Author: | D. K. Lamatsch, V. Trifonov, S. Schories, J. T. Epplen, M. Schmid, M. Schartl |
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URN: | urn:nbn:de:bvb:20-opus-196785 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Humangenetik |
Medizinische Fakultät / Theodor-Boveri-Institut für Biowissenschaften | |
Language: | English |
Parent Title (English): | Cytogenetic and Genome Research |
ISSN: | 1424-8581 |
ISSN: | 1424-859X |
Year of Completion: | 2011 |
Volume: | 135 |
Issue: | 2 |
Pagenumber: | 135-142 |
Source: | Cytogenetic and Genome Research 2011;135(2):135–142. DOI: 10.1159/000331271 |
DOI: | https://doi.org/10.1159/000331271 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/21952475 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | AFLP; B chromosomes; asexual reproduction; gynogenesis; microdissection; paternal introgression; telomeres |
Release Date: | 2021/08/20 |
Date of first Publication: | 2011/09/21 |
Note: | This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. |
Licence (German): | Deutsches Urheberrecht |