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Melt electrowriting of isomalt for high‐resolution templating of embedded microchannels

Please always quote using this URN: urn:nbn:de:bvb:20-opus-256401
  • Fabrication of microchannels using 3D printing of sugars as fugitive material is explored in different fields, including microfluidics. However, establishing reproducible methods for the controlled production of sugar structures with sub-100 μm dimensions remains a challenge. This study pioneers the processing of sugars by melt electrowriting (MEW) enabling the fabrication of structures with so far unprecedented resolution from Isomalt. Based on a systematic variation of process parameters, fibers with diameters down to 20 μm can beFabrication of microchannels using 3D printing of sugars as fugitive material is explored in different fields, including microfluidics. However, establishing reproducible methods for the controlled production of sugar structures with sub-100 μm dimensions remains a challenge. This study pioneers the processing of sugars by melt electrowriting (MEW) enabling the fabrication of structures with so far unprecedented resolution from Isomalt. Based on a systematic variation of process parameters, fibers with diameters down to 20 μm can be fabricated. The flexibility in the adjustment of fiber diameter by on-demand alteration of MEW parameters enables generating constructs with perfusable channels within polydimethylsiloxane molds. These channels have a diameter that can be adjusted from 30 to 200 μm in a single design. Taken together, the experiments show that MEW strongly benefits from the thermal and physical stability of Isomalt, providing a robust platform for the fabrication of small-diameter embedded microchannel systems.show moreshow less

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Metadaten
Author: Ali NadernezhadORCiD, Matthias Ryma, Hatice Genç, Iwona CichaORCiD, Thomasz JüngstORCiD, Jürgen GrollORCiD
URN:urn:nbn:de:bvb:20-opus-256401
Document Type:Journal article
Faculties:Medizinische Fakultät / Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde
Language:English
Parent Title (English):Advanced Material Technologies
Year of Completion:2021
Volume:6
Issue:8
Article Number:2100221
Source:Advanced Materials Technologies (2021) 6:8, 2100221. DOI: 10.1002/admt.202100221
DOI:https://doi.org/10.1002/admt.202100221
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:embedded templating; medicine; melt electrowriting; microfibers; microfluidics; sacrificial printing; sugar glass printing
Release Date:2022/02/22
EU-Project number / Contract (GA) number:874827
OpenAIRE:OpenAIRE
Licence (German):License LogoCC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell 4.0 International