The search result changed since you submitted your search request. Documents might be displayed in a different sort order.
  • search hit 1 of 16
Back to Result List

Health status instruments for patients with COPD in pulmonary rehabilitation: defining a minimal clinically important difference

Please always quote using this URN: urn:nbn:de:bvb:20-opus-166327
  • The minimal clinically important difference (MCID) defines to what extent change on a health status instrument is clinically relevant, which aids scientists and physicians in measuring therapy effects. This is the first study that aimed to establish the MCID of the Clinical chronic obstructive pulmonary disease (COPD) Questionnaire (CCQ), the COPD Assessment Test (CAT) and the St George’s Respiratory Questionnaire (SGRQ) in the same pulmonary rehabilitation population using multiple approaches. In total, 451 COPD patients participated in aThe minimal clinically important difference (MCID) defines to what extent change on a health status instrument is clinically relevant, which aids scientists and physicians in measuring therapy effects. This is the first study that aimed to establish the MCID of the Clinical chronic obstructive pulmonary disease (COPD) Questionnaire (CCQ), the COPD Assessment Test (CAT) and the St George’s Respiratory Questionnaire (SGRQ) in the same pulmonary rehabilitation population using multiple approaches. In total, 451 COPD patients participated in a 3-week Pulmonary Rehabilitation (PR) programme (58 years, 65% male, 43 pack-years, GOLD stage II/III/IV 50/39/11%). Techniques used to assess the MCID were anchor-based approaches, including patient-referencing, criterion-referencing and questionnaire-referencing, and the distribution-based methods standard error of measurement (SEM), 1.96SEM and half standard deviation (0.5s.d.). Patient- and criterion-referencing led to MCID estimates of 0.56 and 0.62 (CCQ); 3.12 and 2.96 (CAT); and 8.40 and 9.28 (SGRQ). Questionnaire-referencing suggested MCID ranges of 0.28–0.61 (CCQ), 1.46–3.08 (CAT) and 6.86–9.47 (SGRQ). The SEM, 1.96SEM and 0.5s.d. were 0.29, 0.56 and 0.46 (CCQ); 3.28, 6.43 and 2.80 (CAT); 5.20, 10.19 and 6.06 (SGRQ). Pooled estimates were 0.52 (CCQ), 3.29 (CAT) and 7.91 (SGRQ) for improvement. MCID estimates differed depending on the method used. Pooled estimates suggest clinically relevant improvements needing to exceed 0.40 on the CCQ, 3.00 on the CAT and 7.00 on the SGRQ for moderate to very severe COPD patients. The MCIDs of the CAT and SGRQ in the literature might be too low, leading to overestimation of treatment effects for patients with COPD.show moreshow less

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar Statistics
Metadaten
Author: Harma Alma, Corina de Jong, Danijel Jelusic, Michael Wittmann, Michael Schuler, Bertine Flokstra-de Blok, Janwillem Kocks, Konrad Schultz, Thys van der Molen
URN:urn:nbn:de:bvb:20-opus-166327
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Psychotherapie und Medizinische Psychologie
Language:English
Parent Title (English):npj Primary Care Respiration Medicine
Year of Completion:2016
Volume:26
Issue:16041
Source:npj Primary Care Respiration Medicine (2016) 26, 16041. DOI: 10.1038/npjpcrm.2016.41
DOI:https://doi.org/10.1038/npjpcrm.2016.41
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:COPD; health status instruments; rehabilitation
Release Date:2019/07/05
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International