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Combinations of hydrogels and mesenchymal stromal cells (MSCs) for cartilage tissue engineering — a review of the literature

Please always quote using this URN: urn:nbn:de:bvb:20-opus-250177
  • Cartilage offers limited regenerative capacity. Cell-based approaches have emerged as a promising alternative in the treatment of cartilage defects and osteoarthritis. Due to their easy accessibility, abundancy, and chondrogenic potential mesenchymal stromal cells (MSCs) offer an attractive cell source. MSCs are often combined with natural or synthetic hydrogels providing tunable biocompatibility, biodegradability, and enhanced cell functionality. In this review, we focused on the different advantages and disadvantages of various natural,Cartilage offers limited regenerative capacity. Cell-based approaches have emerged as a promising alternative in the treatment of cartilage defects and osteoarthritis. Due to their easy accessibility, abundancy, and chondrogenic potential mesenchymal stromal cells (MSCs) offer an attractive cell source. MSCs are often combined with natural or synthetic hydrogels providing tunable biocompatibility, biodegradability, and enhanced cell functionality. In this review, we focused on the different advantages and disadvantages of various natural, synthetic, and modified hydrogels. We examined the different combinations of MSC-subpopulations and hydrogels used for cartilage engineering in preclinical and clinical studies and reviewed the effects of added growth factors or gene transfer on chondrogenesis in MSC-laden hydrogels. The aim of this review is to add to the understanding of the disadvantages and advantages of various combinations of MSC-subpopulations, growth factors, gene transfers, and hydrogels in cartilage engineering.show moreshow less

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Metadaten
Author: Mike Wagenbrenner, Susanne Mayer-Wagner, Maximilian Rudert, Boris Michael Holzapfel, Manuel Weissenberger
URN:urn:nbn:de:bvb:20-opus-250177
Document Type:Journal article
Faculties:Medizinische Fakultät / Lehrstuhl für Orthopädie
Language:English
Parent Title (English):Gels
ISSN:2310-2861
Year of Completion:2021
Volume:7
Issue:4
Article Number:217
Source:Gels (2021) 7:4, 217. https://doi.org/10.3390/gels7040217
DOI:https://doi.org/10.3390/gels7040217
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:MSCs; cartilage defects; cartilage regeneration; hydrogels; osteoarthritis; tissue engineering
Release Date:2022/11/24
Date of first Publication:2021/11/16
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International