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DNA Damage in Chronic Kidney Disease: Evaluation of Clinical Biomarkers

Please always quote using this URN: urn:nbn:de:bvb:20-opus-166569
  • Patients with chronic kidney disease (CKD) exhibit an increased cancer risk compared to a healthy control population. To be able to estimate the cancer risk of the patients and to assess the impact of interventional therapies thereon, it is of particular interest to measure the patients’ burden of genomic damage. Chromosomal abnormalities, reduced DNA repair, and DNA lesions were found indeed in cells of patients with CKD. Biomarkers for DNA damage measurable in easily accessible cells like peripheral blood lymphocytes are chromosomalPatients with chronic kidney disease (CKD) exhibit an increased cancer risk compared to a healthy control population. To be able to estimate the cancer risk of the patients and to assess the impact of interventional therapies thereon, it is of particular interest to measure the patients’ burden of genomic damage. Chromosomal abnormalities, reduced DNA repair, and DNA lesions were found indeed in cells of patients with CKD. Biomarkers for DNA damage measurable in easily accessible cells like peripheral blood lymphocytes are chromosomal aberrations, structural DNA lesions, and oxidatively modified DNA bases. In this review the most common methods quantifying the three parameters mentioned above, the cytokinesis-block micronucleus assay, the comet assay, and the quantification of 8-oxo-7,8-dihydro-2′-deoxyguanosine, are evaluated concerning the feasibility of the analysis and regarding the marker’s potential to predict clinical outcomes.show moreshow less

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Metadaten
Author: Nicole Schupp, Helga Stopper, August Heidland
URN:urn:nbn:de:bvb:20-opus-166569
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Pharmakologie und Toxikologie
Medizinische Fakultät / Medizinische Klinik und Poliklinik I
Language:English
Parent Title (English):Oxidative Medicine and Cellular Longevity
Year of Completion:2016
Volume:2016
Issue:3592042
Source:Oxidative Medicine and Cellular Longevity, Volume 2016, Article ID 3592042. DOI: 10.1155/2016/3592042
DOI:https://doi.org/10.1155/2016/3592042
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:DNA damage; biomarkers; cancer risk; chronic kidney disease
Release Date:2019/07/08
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International