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The Correlation between the Virus- and Brain Antigen-Specific B Cell Response in the Blood of Patients with Multiple Sclerosis
Please always quote using this URN: urn:nbn:de:bvb:20-opus-146946
- There is a largely divergent body of literature regarding the relationship between Epstein-Barr virus (EBV) infection and brain inflammation in multiple sclerosis (MS). Here, we tested MS patients during relapse (n = 11) and in remission (n = 19) in addition to n = 22 healthy controls to study the correlation between the EBV- and brain-specific B cell response in the blood by enzyme-linked immunospot (ELISPOT) and enzyme-linked immunosorbent assay (ELISA). Cytomegalovirus (CMV) was used as a control antigen tested in n = 16 MS patients duringThere is a largely divergent body of literature regarding the relationship between Epstein-Barr virus (EBV) infection and brain inflammation in multiple sclerosis (MS). Here, we tested MS patients during relapse (n = 11) and in remission (n = 19) in addition to n = 22 healthy controls to study the correlation between the EBV- and brain-specific B cell response in the blood by enzyme-linked immunospot (ELISPOT) and enzyme-linked immunosorbent assay (ELISA). Cytomegalovirus (CMV) was used as a control antigen tested in n = 16 MS patients during relapse and in n = 35 patients in remission. Over the course of the study, n = 16 patients were untreated, while n = 33 patients received immunomodulatory therapy. The data show that there was a moderate correlation between the frequencies of EBV- and brain-reactive B cells in MS patients in remission. In addition we could detect a correlation between the B cell response to EBV and disease activity. There was no evidence of an EBV reactivation. Interestingly, there was also a correlation between the frequencies of CMV- and brain-specific B cells in MS patients experiencing an acute relapse and an elevated B cell response to CMV was associated with higher disease activity. The trend remained when excluding seronegative subjects but was non-significant. These data underline that viral infections might impact the immunopathology of MS, but the exact link between the two entities remains subject of controversy.…
Author: | Marie Wunsch, Christopher Hohmann, Bianca Milles, Christina Rostermund, Paul V. Lehmann, Michael Schroeter, Antonios Bayas, Jochen Ulzheimer, Mathias Mäurer, Süleyman Ergün, Stefanie Kuerten |
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URN: | urn:nbn:de:bvb:20-opus-146946 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Anatomie und Zellbiologie |
Language: | English |
Parent Title (English): | Viruses |
Year of Completion: | 2016 |
Volume: | 8 |
Issue: | 4 |
Pagenumber: | 105 |
Source: | Viruses 2016, 8, 105; doi:10.3390/v8040105 |
DOI: | https://doi.org/10.3390/v8040105 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten |
Tag: | B cells; CMV; EBV; ELISPOT; MS |
Release Date: | 2017/05/05 |
Collections: | Open-Access-Publikationsfonds / Förderzeitraum 2016 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |