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Investigation of drug release modulation from poly(2-oxazoline) micelles through ultrasound

Please always quote using this URN: urn:nbn:de:bvb:20-opus-227277
  • Among external stimuli used to trigger release of a drug from a polymeric carrier, ultrasound has gained increasing attention due to its non-invasive nature, safety and low cost. Despite this attention, there is only limited knowledge about how materials available for the preparation of drug carriers respond to ultrasound. This study investigates the effect of ultrasound on the release of a hydrophobic drug, dexamethasone, from poly(2-oxazoline)-based micelles. Spontaneous and ultrasound-mediated release of dexamethasone from five types ofAmong external stimuli used to trigger release of a drug from a polymeric carrier, ultrasound has gained increasing attention due to its non-invasive nature, safety and low cost. Despite this attention, there is only limited knowledge about how materials available for the preparation of drug carriers respond to ultrasound. This study investigates the effect of ultrasound on the release of a hydrophobic drug, dexamethasone, from poly(2-oxazoline)-based micelles. Spontaneous and ultrasound-mediated release of dexamethasone from five types of micelles made of poly(2-oxazoline) block copolymers, composed of hydrophilic poly(2-methyl-2-oxazoline) and hydrophobic poly(2-n-propyl-2-oxazoline) or poly(2-butyl-2-oxazoline-co-2-(3-butenyl)-2-oxazoline), was studied. The release profiles were fitted by zeroorder and Ritger-Peppas models. The ultrasound increased the amount of released dexamethasone by 6% to 105% depending on the type of copolymer, the amount of loaded dexamethasone, and the stimulation time point. This study investigates for the first time the interaction between different poly(2-oxazoline)-based micelle formulations and ultrasound waves, quantifying the efficacy of such stimulation in modulating dexamethasone release from these nanocarriers.show moreshow less

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Metadaten
Author: Alice Rita Salgarella, Anna Zahoranová, Petra Šrámková, Monika Majerčíková, Ewa Pavlova, Robert Luxenhofer, Juraj Kronek, Igor Lacík, Leonardo Ricotti
URN:urn:nbn:de:bvb:20-opus-227277
Document Type:Journal article
Faculties:Fakultät für Chemie und Pharmazie / Institut für Funktionsmaterialien und Biofabrikation
Language:English
Parent Title (English):Scientific Reports
Year of Completion:2018
Volume:8
Pagenumber:9893, 1-13
Source:Scientific Reports (2018) 8:9893
DOI:https://doi.org/10.1038/s41598-018-28140-3
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 543 Analytische Chemie
Tag:Acoustics; Biomedical engineering; Drug delivery; Materials chemistry
Release Date:2022/06/21
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International