Troubleshooting gait disturbances in Parkinson’s disease with deep brain stimulation
Please always quote using this URN: urn:nbn:de:bvb:20-opus-274007
- Deep brain stimulation (DBS) of the subthalamic nucleus or the globus pallidus is an established treatment for Parkinson’s disease (PD) that yields a marked and lasting improvement of motor symptoms. Yet, DBS benefit on gait disturbances in PD is still debated and can be a source of dissatisfaction and poor quality of life. Gait disturbances in PD encompass a variety of clinical manifestations and rely on different pathophysiological bases. While gait disturbances arising years after DBS surgery can be related to disease progression, earlyDeep brain stimulation (DBS) of the subthalamic nucleus or the globus pallidus is an established treatment for Parkinson’s disease (PD) that yields a marked and lasting improvement of motor symptoms. Yet, DBS benefit on gait disturbances in PD is still debated and can be a source of dissatisfaction and poor quality of life. Gait disturbances in PD encompass a variety of clinical manifestations and rely on different pathophysiological bases. While gait disturbances arising years after DBS surgery can be related to disease progression, early impairment of gait may be secondary to treatable causes and benefits from DBS reprogramming. In this review, we tackle the issue of gait disturbances in PD patients with DBS by discussing their neurophysiological basis, providing a detailed clinical characterization, and proposing a pragmatic programming approach to support their management.…
Author: | Nicoló G. Pozzi, Chiara Palmisano, Martin M. Reich, Philip Capetian, Claudio Pacchetti, Jens Volkmann, Ioannis U. Isaias |
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URN: | urn:nbn:de:bvb:20-opus-274007 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Neurologische Klinik und Poliklinik |
Language: | English |
Parent Title (English): | Frontiers in Human Neuroscience |
ISSN: | 1662-5161 |
Year of Completion: | 2022 |
Volume: | 16 |
Article Number: | 806513 |
Source: | Frontiers in Human Neuroscience (2022) 16:806513. DOI:10.3389/fnhum.2022.806513 |
DOI: | https://doi.org/10.3389/fnhum.2022.806513 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Parkinson’s disease; deep brain stimulation (DBS); freezing of gait (FOG); globus pallidus pars interna (GPi); pedunculopontine nucleus (PPN); subthalamic nucleus (STN) |
Release Date: | 2023/04/14 |
Date of first Publication: | 2022/05/16 |
Open-Access-Publikationsfonds / Förderzeitraum 2022 | |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |