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Editorial: Cardiac Innervation Imaging as a Risk Stratification Tool for Potential Device Therapy Candidates

Please always quote using this URN: urn:nbn:de:bvb:20-opus-168465
  • As a scintigraphic approach evaluating cardiac nerve integrity, \(^{123}\)I-metaiodobenzylguanidine (123I-mIBG) has been recently Food and Drug Administration approved. A great deal of progress has been made by the prospective ADMIRE-HF trial, which primarily demonstrated the association of denervated myocardium assessed by \(^{123}\)I-mIBG and cardiac events. However, apart from risk stratification, myocardial nerve function evaluated by molecular imaging should also be expanded to other clinical contexts, in particular to guide the referringAs a scintigraphic approach evaluating cardiac nerve integrity, \(^{123}\)I-metaiodobenzylguanidine (123I-mIBG) has been recently Food and Drug Administration approved. A great deal of progress has been made by the prospective ADMIRE-HF trial, which primarily demonstrated the association of denervated myocardium assessed by \(^{123}\)I-mIBG and cardiac events. However, apart from risk stratification, myocardial nerve function evaluated by molecular imaging should also be expanded to other clinical contexts, in particular to guide the referring cardiologist in selecting appropriate candidates for specific therapeutic interventions. In the present issue of the Journal of Nuclear Cardiology, the use of 123I-mIBG for identifying cardiomyopathy patients, which would most likely not benefit from ICD due low risk of arrhythmias, is described. If we aim to deliver on the promise of cardiac innervation imaging as a powerful tool for risk stratification in a manner similar to nuclear oncology, studies such as the one reviewed here may imply an important step to lay the proper groundwork for a more widespread adoption in clinical practice.show moreshow less

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Metadaten
Author: Rudolf A. Werner
URN:urn:nbn:de:bvb:20-opus-168465
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Nuklearmedizin
Language:English
Parent Title (English):Journal of Nuclear Cardiology
ISSN:1071-3581
Year of Completion:2018
Source:Journal of Nuclear Cardiology 2018 doi:10.1007/s12350-018-01475-0
URL:https://rdcu.be/970i
DOI:https://doi.org/10.1007/s12350-018-01475-0
Sonstige beteiligte Institutionen:Johns Hopkins Medicine
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
GND Keyword:SPECT
Tag:123I-mIBG; 123I-metaiodobenzylguanidine; ICD; SPECT; arrhythmia; cardiac innervation imaging; cardiac nerve; myocardial nerve
Release Date:2018/10/29
Note:
SharedIt-Link zur Publikation: 
https://rdcu.be/970i
Note:
This is a post-peer-review, pre-copyedit version of an article published in Journal of Nuclear Cardiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12350-018-01475-0
Embargo Date:2019/10/24
EU-Project number / Contract (GA) number:701983
OpenAIRE:OpenAIRE
Licence (German):License LogoDeutsches Urheberrecht