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Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

Please always quote using this URN: urn:nbn:de:bvb:20-opus-120714
  • Background Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods First, we performed an adjusted 1-stage random-effectBackground Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes. Results Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). Conclusion Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth."show moreshow less

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Author: Agnes M. M. Sonnenschein-van der Voort, Lidia R. Arends, Johan C. de Jongste, Isabella Annesi-Maesano, S. Hasan Arshad, Henrique Barros, Mikel Basterrechea, Hans Bisgaard, Leda Chatzi, Eva Corpeleijn, Sofia Correia, Leone C. Craig, Graham Devereux, Cristian Dogaru, Miroslav Dostal, Karel Duchen, Merete Eggesbø, C. Kors van der Ent, Maria P. Fantini, Francesco Forastiere, Urs Frey, Ulrike Gehring, Davide Gori, Anne C. van der Gugten, Wojciech Hanke, A. John Henderson, Barbara Heude, Carmen Iñiguez, Hazel M. Inskip, Thomas Keil, Cecily C. Kelleher, Manolis Kogevinas, Eskil Kreiner-Møller, Claudia E. Kuehni, Leanne K. Küpers, Kinga Lancz, Pernille S. Larsen, Susanne Lau, Johnny Ludvigsson, Monique Mommers, Anne-Marie Nybo Andersen, Lubica Palkovicova, Katherine C. Pike, Constanza Pizzi, Kinga Polanska, Daniela Porta, Lorenzo Richiardi, Graham Roberts, Anne Schmidt, Radim J. Sram, Jordi Sunyer, Carel Thijs, Maties Torrent, Karien Viljoen, Alet H. Wijga, Martine Vrijheid, Vincent W. V. Jaddoe, Liesbeth Duijts
URN:urn:nbn:de:bvb:20-opus-120714
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Klinische Epidemiologie und Biometrie
Language:English
Parent Title (English):The Journal of Allergy and Clinical Immunology
Year of Completion:2014
Volume:133
Issue:5
Pagenumber:1317-29
Source:The Journal of Allergy and Clinical Immunology 2014;133:1317-29. DOI:10.1016/j.jaci.2013.12.1082
DOI:https://doi.org/10.1016/j.jaci.2013.12.1082
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/24529685
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:asthma; children; cohort studies; epidemiology; gestational age; infant growth; low birth weight; wheezing
Release Date:2016/02/15
EU-Project number / Contract (GA) number:229571
OpenAIRE:OpenAIRE
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung