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Anti-Parasitic Compounds from Streptomyces sp. Strains Isolated from Mediterranean Sponges

Please always quote using this URN: urn:nbn:de:bvb:20-opus-68312
  • Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70% of the naturally derived antibiotics that are currently in clinical use. In this study, we report on the isolation of Streptomyces sp. strains from Mediterranean sponges, on their secondary metabolite production and on their screening for anti-infective activities. Bioassay-guided isolation and purification yielded three previously known compounds namely, cyclic depsipeptide valinomycin, indolocarbazole alkaloid staurosporine and butenolide.Actinomycetes are prolific producers of pharmacologically important compounds accounting for about 70% of the naturally derived antibiotics that are currently in clinical use. In this study, we report on the isolation of Streptomyces sp. strains from Mediterranean sponges, on their secondary metabolite production and on their screening for anti-infective activities. Bioassay-guided isolation and purification yielded three previously known compounds namely, cyclic depsipeptide valinomycin, indolocarbazole alkaloid staurosporine and butenolide. This is the first report of the isolation of valinomycin from a marine source. These compounds exhibited novel anti-parasitic activities specifically against Leishmania major (valinomycin IC50 < 0.11 μM; staurosporine IC50 5.30 μM) and Trypanosoma brucei brucei (valinomycin IC50 0.0032 μM; staurosporine IC50 0.022 μM; butenolide IC50 31.77 μM). These results underscore the potential of marine actinomycetes to produce bioactive compounds as well as the re-evaluation of previously known compounds for novel anti-infective activities.show moreshow less

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Metadaten
Author: Sheila Marie Pimentel-Elardo, Svitlana Kozytska, Tim S. Bugni, Chris M. Ireland, Heidrun Moll, Ute Hentschel
URN:urn:nbn:de:bvb:20-opus-68312
Document Type:Journal article
Faculties:Fakultät für Biologie / Julius-von-Sachs-Institut für Biowissenschaften
Language:English
Year of Completion:2010
Source:In: Marine Drugs (2010) 8, 2, 373-380, DOI: 10.3390/md8020373
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
GND Keyword:Biologie
Tag:Streptomyces; anti-parasitic; butenolide; marine sponges; staurosporine; valinomycin
Release Date:2012/10/30
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung