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Nanocellulose composites as smart devices with chassis, light-directed DNA Storage, engineered electronic properties, and chip integration

Please always quote using this URN: urn:nbn:de:bvb:20-opus-283033
  • The rapid development of green and sustainable materials opens up new possibilities in the field of applied research. Such materials include nanocellulose composites that can integrate many components into composites and provide a good chassis for smart devices. In our study, we evaluate four approaches for turning a nanocellulose composite into an information storage or processing device: 1) nanocellulose can be a suitable carrier material and protect information stored in DNA. 2) Nucleotide-processing enzymes (polymerase and exonuclease) canThe rapid development of green and sustainable materials opens up new possibilities in the field of applied research. Such materials include nanocellulose composites that can integrate many components into composites and provide a good chassis for smart devices. In our study, we evaluate four approaches for turning a nanocellulose composite into an information storage or processing device: 1) nanocellulose can be a suitable carrier material and protect information stored in DNA. 2) Nucleotide-processing enzymes (polymerase and exonuclease) can be controlled by light after fusing them with light-gating domains; nucleotide substrate specificity can be changed by mutation or pH change (read-in and read-out of the information). 3) Semiconductors and electronic capabilities can be achieved: we show that nanocellulose is rendered electronic by iodine treatment replacing silicon including microstructures. Nanocellulose semiconductor properties are measured, and the resulting potential including single-electron transistors (SET) and their properties are modeled. Electric current can also be transported by DNA through G-quadruplex DNA molecules; these as well as classical silicon semiconductors can easily be integrated into the nanocellulose composite. 4) To elaborate upon miniaturization and integration for a smart nanocellulose chip device, we demonstrate pH-sensitive dyes in nanocellulose, nanopore creation, and kinase micropatterning on bacterial membranes as well as digital PCR micro-wells. Future application potential includes nano-3D printing and fast molecular processors (e.g., SETs) integrated with DNA storage and conventional electronics. This would also lead to environment-friendly nanocellulose chips for information processing as well as smart nanocellulose composites for biomedical applications and nano-factories.show moreshow less

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Metadaten
Author: Elena Bencurova, Sergey Shityakov, Dominik Schaack, Martin Kaltdorf, Edita Sarukhanyan, Alexander Hilgarth, Christin Rath, Sergio Montenegro, Günter Roth, Daniel Lopez, Thomas Dandekar
URN:urn:nbn:de:bvb:20-opus-283033
Document Type:Journal article
Faculties:Fakultät für Mathematik und Informatik / Institut für Informatik
Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):Frontiers in Bioengineering and Biotechnology
ISSN:2296-4185
Year of Completion:2022
Volume:10
Article Number:869111
Source:Frontiers in Bioengineering and Biotechnology (2022) 10:869111. DOI:10.3389/fbioe.2022.869111
DOI:https://doi.org/10.3389/fbioe.2022.869111
Dewey Decimal Classification:0 Informatik, Informationswissenschaft, allgemeine Werke / 00 Informatik, Wissen, Systeme / 004 Datenverarbeitung; Informatik
5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Tag:DNA storage; light-gated proteins; nanocellulose; protein chip; single-electron transistors
Release Date:2023/04/11
Date of first Publication:2022/08/08
Open-Access-Publikationsfonds / Förderzeitraum 2022
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International