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An essential role of the mouse synapse-associated protein Syap1 in circuits for spontaneous motor activity and rotarod balance

Please always quote using this URN: urn:nbn:de:bvb:20-opus-201986
  • Synapse-associated protein 1 (Syap1) is the mammalian homologue of synapse-associated protein of 47 kDa (Sap47) in Drosophila. Genetic deletion of Sap47 leads to deficiencies in short-term plasticity and associative memory processing in flies. In mice, Syap1 is prominently expressed in the nervous system, but its function is still unclear. We have generated Syap1 knockout mice and tested motor behaviour and memory. These mice are viable and fertile but display distinct deficiencies in motor behaviour. Locomotor activity specifically appears toSynapse-associated protein 1 (Syap1) is the mammalian homologue of synapse-associated protein of 47 kDa (Sap47) in Drosophila. Genetic deletion of Sap47 leads to deficiencies in short-term plasticity and associative memory processing in flies. In mice, Syap1 is prominently expressed in the nervous system, but its function is still unclear. We have generated Syap1 knockout mice and tested motor behaviour and memory. These mice are viable and fertile but display distinct deficiencies in motor behaviour. Locomotor activity specifically appears to be reduced in early phases when voluntary movement is initiated. On the rotarod, a more demanding motor test involving control by sensory feedback, Syap1-deficient mice dramatically fail to adapt to accelerated speed or to a change in rotation direction. Syap1 is highly expressed in cerebellar Purkinje cells and cerebellar nuclei. Thus, this distinct motor phenotype could be due to a so-far unknown function of Syap1 in cerebellar sensorimotor control. The observed motor defects are highly specific since other tests in the modified SHIRPA exam, as well as cognitive tasks like novel object recognition, Pavlovian fear conditioning, anxiety-like behaviour in open field dark-light transition and elevated plus maze do not appear to be affected in Syap1 knockout mice.show moreshow less

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Metadaten
Author: Cora R. von Collenberg, Dominique Schmitt, Thomas Rülicke, Michael Sendtner, Robert Blum, Erich Buchner
URN:urn:nbn:de:bvb:20-opus-201986
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Klinische Neurobiologie
Language:English
Parent Title (English):Biology Open
Year of Completion:2019
Volume:8
Pagenumber:bio042366
Source:Biology Open (2019) 8:042366. https://doi.org/10.1242/bio.042366
DOI:https://doi.org/10.1242/bio.042366
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Tag:Associative learning; Fear conditioning; Motor behaviour; Object recognition; Syap1 knockout
Release Date:2020/05/13
Collections:Open-Access-Publikationsfonds / Förderzeitraum 2019
Note:
PDF includes: Correction: An essential role of the mouse synapse-associated protein Syap1 in circuits for spontaneous motor activity and rotarod balance - February 15, 2020. Biology Open (2020) 9, bio048942. doi:10.1242/bio.048942
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International