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Karyotype complexity and prognosis in acute myeloid leukemia

Please always quote using this URN: urn:nbn:de:bvb:20-opus-164530
  • A complex aberrant karyotype consisting of multiple unrelated cytogenetic abnormalities is associated with poor prognosis in patients with acute myeloid leukemia (AML). The European Leukemia Net classification and the UK Medical Research Council recommendation provide prognostic categories that differ in the definition of unbalanced aberrations as well as the number of single aberrations. The aim of this study on 3526 AML patients was to redefine and validate a cutoff for karyotype complexity in AML with regard to adverse prognosis. Our studyA complex aberrant karyotype consisting of multiple unrelated cytogenetic abnormalities is associated with poor prognosis in patients with acute myeloid leukemia (AML). The European Leukemia Net classification and the UK Medical Research Council recommendation provide prognostic categories that differ in the definition of unbalanced aberrations as well as the number of single aberrations. The aim of this study on 3526 AML patients was to redefine and validate a cutoff for karyotype complexity in AML with regard to adverse prognosis. Our study demonstrated that (1) patients with a pure hyperdiploid karyotype have an adverse risk irrespective of the number of chromosomal gains, (2) patients with translocation t(9;11)(p21∼22;q23) have an intermediate risk independent of the number of additional aberrations, (3) patients with 4 abnormalities have an adverse risk per se and (4) patients with three aberrations in the absence of abnormalities of strong influence (hyperdiploid karyotype, t(9;11)(p21∼22;q23), CBF-AML, unique adverse-risk aberrations) have borderline intermediate/adverse risk with a reduced overall survival compared with patients with a normal karyotype.show moreshow less

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Author: F. Stölzel, B. Mohr, M. Kramer, U. Oelschlägel, T. Bochtler, W. E. Berdel, M. Kaufmann, C. D. Baldus, K. Schäfer-Eckart, R. Stuhlmann, H. Einsele, S. W. Krause, H. Serve, M. Hänel, R. Herbst, A. Neubauer, K. Sohlbach, J. Mayer, J. M. Middeke, U. Platzbecker, M. Schaich, A. Krämer, C. Röllig, J. Schetelig, M. Bornhäuser, G. Ehninger
URN:urn:nbn:de:bvb:20-opus-164530
Document Type:Journal article
Faculties:Medizinische Fakultät / Medizinische Klinik und Poliklinik II
Language:English
Parent Title (English):Blood Cancer Journal
Year of Completion:2016
Volume:6
Pagenumber:e386
Source:Blood Cancer Journal (2016) 6, e386
DOI:https://doi.org/10.1038/bcj.2015.114
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Cancer genetics; Genetics research
Release Date:2020/01/08
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International