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Independent natural genetic variation of punishment- versus relief-memory

Please always quote using this URN: urn:nbn:de:bvb:20-opus-186554
  • A painful event establishes two opponent memories: cues that are associated with pain onset are remembered negatively, whereas cues that coincide with the relief at pain offset acquire positive valence. Such punishment-versus relief-memories are conserved across species, including humans, and the balance between them is critical for adaptive behaviour with respect to pain and trauma. In the fruit fly, Drosophila melanogaster as a study case, we found that both punishment-and relief-memories display natural variation across wild-derived inbredA painful event establishes two opponent memories: cues that are associated with pain onset are remembered negatively, whereas cues that coincide with the relief at pain offset acquire positive valence. Such punishment-versus relief-memories are conserved across species, including humans, and the balance between them is critical for adaptive behaviour with respect to pain and trauma. In the fruit fly, Drosophila melanogaster as a study case, we found that both punishment-and relief-memories display natural variation across wild-derived inbred strains, but they do not covary, suggesting a considerable level of dissociation in their genetic effectors. This provokes the question whether there may be heritable inter-individual differences in the balance between these opponent memories in man, with potential psycho-clinical implications.show moreshow less

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Metadaten
Author: Mirjam Appel, Claus-Jürgen Scholz, Samet Kocabey, Sinead Savage, Christian König, Ayse Yarali
URN:urn:nbn:de:bvb:20-opus-186554
Document Type:Journal article
Faculties:Medizinische Fakultät
Language:English
Parent Title (English):Biology Letters
Year of Completion:2016
Volume:12
Issue:12
Pagenumber:20160657
Source:Biology Letters (2016) 12:12, 20160657. https://doi.org/10.1098/rsbl.2016.0657
DOI:https://doi.org/10.1098/rsbl.2016.0657
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Drosophila melanogaster; associative memory; fruit-flies; natural genetic variation; opponent processes; punishment; rats; relief; reward
Release Date:2020/05/20
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International