Untersuchungen zur Pathogenität von Antikörpern bei der Epidermolysis bullosa acquisita
Please always quote using this URN: urn:nbn:de:bvb:20-opus-20707
- Erstellung eines Tiermodells für die EBA mittels passiven Transfers von Kaninchenantikörpern gegen Typ VII Kollagen in Mäuse. Immunologische Untersuchungen der EBA im Modell.
- To study the pathogenic relevance of antibodies specific to type VII collagen in vivo, we generated and characterized rabbit antibodies specific to a murine form of this antigen and passively transferred them into BALB/c mice. Immune rabbit IgG bound to the lamina densa of murine skin and immunoblotted type VII collagen. Mice injected with purified IgG specific to type VII collagen, in contrast to control mice, developed subepidermal skin blisters, reproducing the human disease at the clinical, histological, electron microscopical, andTo study the pathogenic relevance of antibodies specific to type VII collagen in vivo, we generated and characterized rabbit antibodies specific to a murine form of this antigen and passively transferred them into BALB/c mice. Immune rabbit IgG bound to the lamina densa of murine skin and immunoblotted type VII collagen. Mice injected with purified IgG specific to type VII collagen, in contrast to control mice, developed subepidermal skin blisters, reproducing the human disease at the clinical, histological, electron microscopical, and immunopathological levels.…
Author: | Barbara Dotterweich |
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URN: | urn:nbn:de:bvb:20-opus-20707 |
Document Type: | Doctoral Thesis |
Granting Institution: | Universität Würzburg, Medizinische Fakultät |
Faculties: | Medizinische Fakultät / Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie |
Date of final exam: | 2006/05/22 |
Language: | German |
Year of Completion: | 2005 |
Source: | J Clin Invest. 2005 Apr;115(4):825-8. |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Autoimmunität; EBA; Tiermodell; passiver Transfer EBA; passive transfer of antibodies |
Release Date: | 2006/12/07 |
Advisor: | Dr.med. Cassian Sitaru |