Untersuchungen zur Pathogenität von Antikörpern bei der Epidermolysis bullosa acquisita

Please always quote using this URN: urn:nbn:de:bvb:20-opus-20707
  • Erstellung eines Tiermodells für die EBA mittels passiven Transfers von Kaninchenantikörpern gegen Typ VII Kollagen in Mäuse. Immunologische Untersuchungen der EBA im Modell.
  • To study the pathogenic relevance of antibodies specific to type VII collagen in vivo, we generated and characterized rabbit antibodies specific to a murine form of this antigen and passively transferred them into BALB/c mice. Immune rabbit IgG bound to the lamina densa of murine skin and immunoblotted type VII collagen. Mice injected with purified IgG specific to type VII collagen, in contrast to control mice, developed subepidermal skin blisters, reproducing the human disease at the clinical, histological, electron microscopical, andTo study the pathogenic relevance of antibodies specific to type VII collagen in vivo, we generated and characterized rabbit antibodies specific to a murine form of this antigen and passively transferred them into BALB/c mice. Immune rabbit IgG bound to the lamina densa of murine skin and immunoblotted type VII collagen. Mice injected with purified IgG specific to type VII collagen, in contrast to control mice, developed subepidermal skin blisters, reproducing the human disease at the clinical, histological, electron microscopical, and immunopathological levels.show moreshow less

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Metadaten
Author: Barbara Dotterweich
URN:urn:nbn:de:bvb:20-opus-20707
Document Type:Doctoral Thesis
Granting Institution:Universität Würzburg, Medizinische Fakultät
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
Date of final exam:2006/05/22
Language:German
Year of Completion:2005
Source:J Clin Invest. 2005 Apr;115(4):825-8.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Autoimmunität; EBA; Tiermodell; passiver Transfer
EBA; passive transfer of antibodies
Release Date:2006/12/07
Advisor:Dr.med. Cassian Sitaru