Molecular cloning of substance P receptor cDNA from guinea-pig uterus
Please always quote using this URN: urn:nbn:de:bvb:20-opus-59293
- A cDNA encoding guinea-pig uterine substance P (SP) receptor has been isolated using the homology screening approach. Northern blot analysis reveals that the corresponding mRNA, of approx. 4.8 kb, is expressed in all tissues tested, but predominantly in the uteri of non-pregnant animals; during pregnancy its expression is reduced. The guinea-pig SP receptor was expressed in COS-7 cells and demonstrated relative Iigand affinity in the order: SP >> neurokinin A > neurokinin B.
| Author: | Valentin Gorboulev, Aida Akhundova, Heike Luzius, Falk Fahrenholz |
|---|---|
| URN: | urn:nbn:de:bvb:20-opus-59293 |
| Document Type: | Journal article |
| Faculties: | Medizinische Fakultät / Institut für Anatomie und Zellbiologie |
| Language: | English |
| Year of Completion: | 1992 |
| Source: | In: Biochimica et Biophysica Acta (1992) 1131, S. 99 - 102. |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| GND Keyword: | Biologie |
| Tag: | COS cell expression; G-protein-coupled receptor; Guinea-pig uterus; Substance P receptor |
| Release Date: | 2011/08/10 |
| Licence (German): |  Deutsches Urheberrecht |