Molecular cloning of substance P receptor cDNA from guinea-pig uterus

Please always quote using this URN: urn:nbn:de:bvb:20-opus-59293
  • A cDNA encoding guinea-pig uterine substance P (SP) receptor has been isolated using the homology screening approach. Northern blot analysis reveals that the corresponding mRNA, of approx. 4.8 kb, is expressed in all tissues tested, but predominantly in the uteri of non-pregnant animals; during pregnancy its expression is reduced. The guinea-pig SP receptor was expressed in COS-7 cells and demonstrated relative Iigand affinity in the order: SP >> neurokinin A > neurokinin B.

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Author: Valentin Gorboulev, Aida Akhundova, Heike Luzius, Falk Fahrenholz
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Anatomie und Zellbiologie
Year of Completion:1992
Source:In: Biochimica et Biophysica Acta (1992) 1131, S. 99 - 102.
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
GND Keyword:Biologie
Tag:COS cell expression; G-protein-coupled receptor; Guinea-pig uterus; Substance P receptor
Release Date:2011/08/10
Licence (German):License LogoDeutsches Urheberrecht