Radiation inactivation analysis of the A\(_1\) adenosine receptor: decrease in radiation inactivation size in the presence of guanine nucleotide

Please always quote using this URN: urn:nbn:de:bvb:20-opus-60318
  • Radiation inactivation analysis of the binding of the A1 adenosine receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes yielded a radiation inactivation size of 58 kDa. In the presence of GTPyS this was reduced to 33 kDa, in good agreement with the size of the ligand-binding subunit detected after photoaffinity labelling. The data indicate that the structural association of A\(_1\) adenosine receptors with G-protein components is altered in situ in the presence of guanine nucleotides.

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Author: M. Reddington, Karl-Norbert Klotz, M. J. Lohse, B. Hietel
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Pharmakologie und Toxikologie
Year of Completion:1989
Source:FEBS Letters (1989) 1, 252, 125-128.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
GND Keyword:Toxikologie
Tag:(Rat brain membrane); A1; Adenosine receptor; G-protein; Radiation inactivation; Target size
Release Date:2011/12/09
Licence (German):License LogoDeutsches Urheberrecht