Injection of thyrotropin releasing hormone into the locus coeruleus increases blood pressure

Please always quote using this URN: urn:nbn:de:bvb:20-opus-72894
  • Thyrotropin releasing hormone (TRH), 10 pmol kg-1 injected in the region of locus coeruleus, caused a rapid (within 1 min) rise of mean arterial pressure in the urethane- naesthetized rat. No clear-cut effects in heart rate or ventilation were observed. When TRH was injected into the lateral ventricle, a dose more than 10-fold higher was required to achieve a comparable rise in arterial pressure. It is concluded that TRH may have a physiological rote in centrat cardiovascular regulation.

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Author: I. Paakkari, Anna-Leena Sirén, M.-L. Nurminen, M. Svartström-Fraser
Document Type:Journal article
Faculties:Medizinische Fakultät / Neurochirurgische Klinik und Poliklinik
Year of Completion:1987
Source:In: European Heart Journal, 1987, Suppl. B, 8, S.147-151.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
GND Keyword:Thyreotropin-Releasinghormon; Blutdruck; Locus coeruleus
Tag:TRH; blood pressure; locus coeruleus
Release Date:2014/06/02
Licence (German):License LogoDeutsches Urheberrecht