Sila-Pharmaka, 31. Mitt. [1] Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon

Sila-Pharmaca, 31 th Communication [1] Synthesis, Structure, and Pharmacological Properties of Diphenyl(2-piperidinoethoxymethyl)silanol and its Carbon Analogue

Please always quote using this URN: urn:nbn:de:bvb:20-opus-128410
  • In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong O-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4a and 4b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ≈4b).

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Author: Reinhold Tacke, Hartwig Lange, William S. Sheldrick, Günter Lambrecht, Ulrich Moser, Ernst Mutschler
Document Type:Journal article
Faculties:Fakultät für Chemie und Pharmazie / Institut für Anorganische Chemie
Parent Title (German):Zeitschrift für Naturforschung B
Year of Completion:1983
Source:Zeitschrift für Naturforschung B. Band 38, Heft 6, Seiten 738–746
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 546 Anorganische Chemie
Tag:antimuscarinic and papaverine-like activity; crystal and molecular structure; sila-substitution
Release Date:2016/03/01
Licence (German):License LogoDeutsches Urheberrecht