Superagonistic CD28 stimulation induces IFN‐γ release from mouse T helper 1 cells in vitro and in vivo

Please always quote using this URN: urn:nbn:de:bvb:20-opus-239028
  • Like human Th1 cells, mouse Th1 cells also secrete IFN‐γ upon stimulation with a superagonistic anti‐CD28 monoclonal antibody (CD28‐SA). Crosslinking of the CD28‐SA via FcR and CD40‐CD40L interactions greatly increased IFN‐γ release. Our data stress the utility of the mouse as a model organism for immune responses in humans.

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Author: Stephanie Haack, Sarah Baiker, Jan Schlegel, Markus Sauer, Tim Sparwasser, Daniela Langenhorst, Niklas Beyersdorf
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Virologie und Immunbiologie
Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Parent Title (English):European Journal of Immunology
Year of Completion:2021
First Page:738
Last Page:741
Source:European Journal of Immunology 2021, 51(3):738–741. DOI: 10.1002/eji.202048803
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:CD28; Superagonistic antibody; Th1 cells; cytokine release; interferon γ
Release Date:2021/12/15
Licence (German):License LogoCC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International