TNAP as a new player in chronic inflammatory conditions and metabolism

Please always quote using this URN: urn:nbn:de:bvb:20-opus-258888
  • This review summarizes important information on the ectoenzyme tissue-nonspecific alkaline phosphatase (TNAP) and gives a brief insight into the symptoms, diagnostics, and treatment of the rare disease Hypophosphatasia (HPP), which is resulting from mutations in the TNAP encoding ALPL gene. We emphasize the role of TNAP beyond its well-known contribution to mineralization processes. Therefore, above all, the impact of the enzyme on central molecular processes in the nervous system and on inflammation is presented here.

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Author: Stephanie Graser, Daniel LiedtkeORCiD, Franz Jakob
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Humangenetik
Medizinische Fakultät / Lehrstuhl für Orthopädie
Parent Title (English):International Journal of Molecular Sciences
Year of Completion:2021
Article Number:919
Source:International Journal of Molecular Sciences (2021) 22:2, 919.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:HPP; Hypophosphatasia; TNAP; inflammation; mineralization; nervous system
Release Date:2022/03/21
Open-Access-Publikationsfonds / Förderzeitraum 2021
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International