TNAP as a new player in chronic inflammatory conditions and metabolism
Please always quote using this URN: urn:nbn:de:bvb:20-opus-258888
- This review summarizes important information on the ectoenzyme tissue-nonspecific alkaline phosphatase (TNAP) and gives a brief insight into the symptoms, diagnostics, and treatment of the rare disease Hypophosphatasia (HPP), which is resulting from mutations in the TNAP encoding ALPL gene. We emphasize the role of TNAP beyond its well-known contribution to mineralization processes. Therefore, above all, the impact of the enzyme on central molecular processes in the nervous system and on inflammation is presented here.
| Author: | Stephanie Graser, Daniel LiedtkeORCiD, Franz Jakob |
|---|---|
| URN: | urn:nbn:de:bvb:20-opus-258888 |
| Document Type: | Journal article |
| Faculties: | Medizinische Fakultät / Institut für Humangenetik |
| Medizinische Fakultät / Lehrstuhl für Orthopädie | |
| Language: | English |
| Parent Title (English): | International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Year of Completion: | 2021 |
| Volume: | 22 |
| Issue: | 2 |
| Article Number: | 919 |
| Source: | International Journal of Molecular Sciences (2021) 22:2, 919. https://doi.org/10.3390/ijms22020919 |
| DOI: | https://doi.org/10.3390/ijms22020919 |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Tag: | HPP; Hypophosphatasia; TNAP; inflammation; mineralization; nervous system |
| Release Date: | 2022/03/21 |
| Collections: | Open-Access-Publikationsfonds / Förderzeitraum 2021 |
| Licence (German): |  CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |