Patients with higher vitamin D levels show stronger improvement of self-reported depressive symptoms in psychogeriatric day-care setting

Please always quote using this URN: urn:nbn:de:bvb:20-opus-268525
  • Depression is a common psychiatric disorder among geriatric patients that decreases the quality of life and increases morbidity and mortality. Vitamin D as a neuro-steroid hormone might play a role in the onset and treatment of depression. In the present study, the association between depressive symptoms and vitamin D concentration in serum was evaluated. 140 patients of a psychogeriatric day-care unit were included. The geriatric depression scale (GDS) and the Hamilton depression rating scale (HDRS) were assessed at the beginning and end ofDepression is a common psychiatric disorder among geriatric patients that decreases the quality of life and increases morbidity and mortality. Vitamin D as a neuro-steroid hormone might play a role in the onset and treatment of depression. In the present study, the association between depressive symptoms and vitamin D concentration in serum was evaluated. 140 patients of a psychogeriatric day-care unit were included. The geriatric depression scale (GDS) and the Hamilton depression rating scale (HDRS) were assessed at the beginning and end of treatment, GDS scores additionally 6 weeks after discharge from the day-care unit. Vitamin D levels were measured at the beginning of the treatment, routinely. Patients with levels below 30 µg/L were treated with 1000 IU vitamin D per day. There was no association between the severity of depressive symptoms and the concentration of vitamin D at the beginning of the treatment. Patients with higher vitamin D levels showed a stronger decline of depressive symptoms measured by the GDS during their stay in the day-care unit. We provide evidence that vitamin D serum levels might influence antidepressant therapy response in a geriatric population. Prospective studies are necessary to determine which patients may profit from add-on vitamin D therapy.show moreshow less

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Metadaten
Author: Linda D. Zech, Maike Scherf-Clavel, Christine Daniels, Michael Schwab, Jürgen Deckert, Stefan Unterecker, Alexandra S. Herr
URN:urn:nbn:de:bvb:20-opus-268525
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie
Language:English
Parent Title (English):Journal of Neural Transmission
ISSN:1435-1463
Year of Completion:2021
Volume:128
Issue:8
Pagenumber:1233-1238
Source:Journal of Neural Transmission 2021, 128(8):1233-1238. DOI: 10.1007/s00702-021-02385-1
DOI:https://doi.org/10.1007/s00702-021-02385-1
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/34304320
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:anti-depressive treatment; depression; psycho-geriatrics; vitamin D deficiency
Release Date:2022/06/08
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International