Verteporfin protects against Th17 cell‐mediated EAE independently of YAP inhibition

Please always quote using this URN: urn:nbn:de:bvb:20-opus-287234
  • The known YAP inhibitor verteporfin is capable of repressing IL‐17A production in Th17 cells. However, this effect is mediated independently of YAP and can ameliorate Th17‐mediated experimental autoimmune encephalomyelitis (EAE) upon in vivo administration. The data suggest verteprofin's mode of action for the design of novel therapeutic autoimmune disease intervention.

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Author: Paulin Brosinsky, Hanna Leister, Nan Cheng, Xaralabos Varelas, Alexander Visekruna, Maik Luu
Document Type:Journal article
Faculties:Medizinische Fakultät / Medizinische Klinik und Poliklinik II
Parent Title (English):European Journal of Immunology
Year of Completion:2022
First Page:1523
Last Page:1526
Source:European Journal of Immunology 2022, 52(9):1523–1526. DOI: 10.1002/eji.202149564
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:EAE; Hippo signaling; Th17 cells; YAP; verteporfin
Release Date:2023/01/18
Licence (German):License LogoCC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell 4.0 International