The role of clusterin transporter in the pathogenesis of Alzheimer’s disease at the blood–brain barrier interface: a systematic review

Please always quote using this URN: urn:nbn:de:bvb:20-opus-290279
  • Alzheimer’s disease (AD) is considered a chronic and debilitating neurological illness that is increasingly impacting older-age populations. Some proteins, including clusterin (CLU or apolipoprotein J) transporter, can be linked to AD, causing oxidative stress. Therefore, its activity can affect various functions involving complement system inactivation, lipid transport, chaperone activity, neuronal transmission, and cellular survival pathways. This transporter is known to bind to the amyloid beta (Aβ) peptide, which is the major pathogenicAlzheimer’s disease (AD) is considered a chronic and debilitating neurological illness that is increasingly impacting older-age populations. Some proteins, including clusterin (CLU or apolipoprotein J) transporter, can be linked to AD, causing oxidative stress. Therefore, its activity can affect various functions involving complement system inactivation, lipid transport, chaperone activity, neuronal transmission, and cellular survival pathways. This transporter is known to bind to the amyloid beta (Aβ) peptide, which is the major pathogenic factor of AD. On the other hand, this transporter is also active at the blood–brain barrier (BBB), a barrier that prevents harmful substances from entering and exiting the brain. Therefore, in this review, we discuss and emphasize the role of the CLU transporter and CLU-linked molecular mechanisms at the BBB interface in the pathogenesis of AD.show moreshow less

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Metadaten
Author: Muhammad Mazhar Fareed, Maryam Qasmi, Shaan Aziz, Elisabeth Völker, Carola Yvette Förster, Sergey Shityakov
URN:urn:nbn:de:bvb:20-opus-290279
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Anästhesiologie (ab 2004)
Language:English
Parent Title (English):Biomolecules
ISSN:2218-273X
Year of Completion:2022
Volume:12
Issue:10
Article Number:1452
Source:Biomolecules (2022) 12:10, 1452. https://doi.org/10.3390/biom12101452
DOI:https://doi.org/10.3390/biom12101452
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:AD pathogenesis; Alzheimer’s disease; Wnt signaling; apolipoprotein J; blood–brain barrier; clusterin transporter
Release Date:2023/10/18
Date of first Publication:2022/10/10
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International