Central serotonin/noradrenaline transporter availability and treatment success in patients with obesity

Please always quote using this URN: urn:nbn:de:bvb:20-opus-290294
  • Serotonin (5-hydroxytryptamine, 5-HT) as well as noradrenaline (NA) are key modulators of various fundamental brain functions including the control of appetite. While manipulations that alter brain serotoninergic signaling clearly affect body weight, studies implicating 5-HT transporters and NA transporters (5-HTT and NAT, respectively) as a main drug treatment target for human obesity have not been conclusive. The aim of this positron emission tomography (PET) study was to investigate how these central transporters are associated with changesSerotonin (5-hydroxytryptamine, 5-HT) as well as noradrenaline (NA) are key modulators of various fundamental brain functions including the control of appetite. While manipulations that alter brain serotoninergic signaling clearly affect body weight, studies implicating 5-HT transporters and NA transporters (5-HTT and NAT, respectively) as a main drug treatment target for human obesity have not been conclusive. The aim of this positron emission tomography (PET) study was to investigate how these central transporters are associated with changes of body weight after 6 months of dietary intervention or Roux-en-Y gastric bypass (RYGB) surgery in order to assess whether 5-HTT as well as NAT availability can predict weight loss and consequently treatment success. The study population consisted of two study cohorts using either the 5-HTT-selective radiotracer [\(^{11}\)C]DASB to measure 5-HTT availability or the NAT-selective radiotracer [\(^{11}\)C]MRB to assess NAT availability. Each group included non-obesity healthy participants, patients with severe obesity (body mass index, BMI, >35 kg/m\(^2\)) following a conservative dietary program (diet) and patients undergoing RYGB surgery within a 6-month follow-up. Overall, changes in BMI were not associated with changes of both 5-HTT and NAT availability, while 5-HTT availability in the dorsal raphe nucleus (DRN) prior to intervention was associated with substantial BMI reduction after RYGB surgery and inversely related with modest BMI reduction after diet. Taken together, the data of our study indicate that 5-HTT and NAT are involved in the pathomechanism of obesity and have the potential to serve as predictors of treatment outcomes.show moreshow less

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Author: Nora-Isabell Griebsch, Johanna Kern, Jonas Hansen, Michael Rullmann, Julia Luthardt, Stephanie Helfmeyer, Franziska J. Dekorsy, Marvin Soeder, Mohammed K. Hankir, Franziska Zientek, Georg-Alexander Becker, Marianne Patt, Philipp M. Meyer, Arne Dietrich, Matthias Blüher, Yu-Shin Ding, Anja Hilbert, Osama Sabri, Swen Hesse
URN:urn:nbn:de:bvb:20-opus-290294
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I)
Language:English
Parent Title (English):Brain Sciences
ISSN:2076-3425
Year of Completion:2022
Volume:12
Issue:11
Article Number:1437
Source:Brain Sciences (2022) 12:11, 1437. https://doi.org/10.3390/brainsci12111437
DOI:https://doi.org/10.3390/brainsci12111437
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:PET; PET imaging; Roux-en-Y gastric bypass surgery; body mass index (BMI; kg/m\(^2\)); noradrenaline; noradrenaline transporter; obesity; radiotracer; serotonin; serotonin transporter
Release Date:2023/11/08
Date of first Publication:2022/10/26
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International