Impact of a specific collagen peptide food supplement on periodontal inflammation in aftercare patients — a randomised controlled trial

Please always quote using this URN: urn:nbn:de:bvb:20-opus-290471
  • Background: This controlled clinical trial evaluated the impact of a specific collagen peptide food supplement on parameters of periodontal inflammation in aftercare patients. Methods: A total of 39 study patients were enrolled. At baseline, bleeding on probing (BoP; primary outcome), gingival index (GI), plaque control record (PCR), recession (REC) and probing pocket depth (PPD) for the calculation of the periodontal inflamed surface area (PISA) were documented. After subsequent professional mechanical plaque removal (PMPR), participants wereBackground: This controlled clinical trial evaluated the impact of a specific collagen peptide food supplement on parameters of periodontal inflammation in aftercare patients. Methods: A total of 39 study patients were enrolled. At baseline, bleeding on probing (BoP; primary outcome), gingival index (GI), plaque control record (PCR), recession (REC) and probing pocket depth (PPD) for the calculation of the periodontal inflamed surface area (PISA) were documented. After subsequent professional mechanical plaque removal (PMPR), participants were randomly provided with a supply of sachets containing either a specific collagen peptide preparation (test group; n = 20) or a placebo (placebo group; n = 19) to be consumed dissolved in liquid once daily until reevaluation at day 90. Results: PMPR supplemented with the consumption of the specific collagen peptides resulted in a significantly lower mean percentage of persisting BoP-positive sites than PMPR plus placebo (test: 10.4% baseline vs. 3.0% reevaluation; placebo: 14.2% baseline vs. 9.4% reevaluation; effect size: 0.86). Mean PISA and GI values were also reduced compared to baseline, with a significant difference in favor of the test group (PISA test: 170.6 mm\(^2\) baseline vs. 53.7 mm\(^2\) reevaluation; PISA placebo: 229.4 mm\(^2\) baseline vs. 184.3 mm\(^2\) reevaluation; GI test: 0.5 baseline vs. 0.1 reevaluation; GI placebo: 0.4 baseline vs. 0.3 reevaluation). PCR was also significantly decreased in both experimental groups at revaluation, but the difference between the groups did not reach the level of significance. Conclusions: The supplementary intake of specific collagen peptides may further enhance the anti-inflammatory effect of PMPR in periodontal recall patients.show moreshow less

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Metadaten
Author: Yvonne Jockel-Schneider, Peggy Stoelzel, Jeanine Hess, Imme Haubitz, Stefan Fickl, Ulrich Schlagenhauf
URN:urn:nbn:de:bvb:20-opus-290471
Document Type:Journal article
Faculties:Medizinische Fakultät / Abteilung für Parodontologie (in der Poliklinik für Zahnerhaltung und Parodontologie)
Language:English
Parent Title (English):Nutrients
ISSN:2072-6643
Year of Completion:2022
Volume:14
Issue:21
Article Number:4473
Source:Nutrients (2022) 14:21, 4473. doi:10.3390/nu14214473
DOI:https://doi.org/10.3390/nu14214473
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:bleeding on probing; collagen; food supplement; gingival; gingivitis; peptide fragment; periodontitis
Release Date:2023/04/21
Date of first Publication:2022/10/25
Open-Access-Publikationsfonds / Förderzeitraum 2022
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International