Metabolic silencing via methionine-based amino acid restriction in head and neck cancer
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-319257
- In recent years, various forms of caloric restriction (CR) and amino acid or protein restriction (AAR or PR) have shown not only success in preventing age-associated diseases, such as type II diabetes and cardiovascular diseases, but also potential for cancer therapy. These strategies not only reprogram metabolism to low-energy metabolism (LEM), which is disadvantageous for neoplastic cells, but also significantly inhibit proliferation. Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumour types, with over 600,000 newIn recent years, various forms of caloric restriction (CR) and amino acid or protein restriction (AAR or PR) have shown not only success in preventing age-associated diseases, such as type II diabetes and cardiovascular diseases, but also potential for cancer therapy. These strategies not only reprogram metabolism to low-energy metabolism (LEM), which is disadvantageous for neoplastic cells, but also significantly inhibit proliferation. Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumour types, with over 600,000 new cases diagnosed annually worldwide. With a 5-year survival rate of approximately 55%, the poor prognosis has not improved despite extensive research and new adjuvant therapies. Therefore, for the first time, we analysed the potential of methionine restriction (MetR) in selected HNSCC cell lines. We investigated the influence of MetR on cell proliferation and vitality, the compensation for MetR by homocysteine, the gene regulation of different amino acid transporters, and the influence of cisplatin on cell proliferation in different HNSCC cell lines.…
Autor(en): | Anna Chiara Wünsch, Elena Ries, Sina Heinzelmann, Andrea Frabschka, Peter Christoph Wagner, Theresa Rauch, Corinna Koderer, Mohamed El-Mesery, Julian Manuel Volland, Alexander Christian Kübler, Stefan Hartmann, Axel Seher |
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URN: | urn:nbn:de:bvb:20-opus-319257 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Current Issues in Molecular Biology |
ISSN: | 1467-3045 |
Erscheinungsjahr: | 2023 |
Band / Jahrgang: | 45 |
Heft / Ausgabe: | 6 |
Erste Seite: | 4557 |
Letzte Seite: | 4573 |
Originalveröffentlichung / Quelle: | Current Issues in Molecular Biology (2023) 45:6, 4557-4573. https://doi.org/10.3390/cimb45060289 |
DOI: | https://doi.org/10.3390/cimb45060289 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | HNSCC; SCCHN; SLC-family; amino acid restriction; amino acid transporter; caloric restriction; cell vitality; cisplatin; low energy metabolism; methionine |
Datum der Freischaltung: | 28.03.2024 |
Datum der Erstveröffentlichung: | 24.05.2023 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |