Intracellular staphylococcus aureus: Live-in and let die
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-123374
- Staphylococcus aureus uses a plethora of virulence factors to accommodate a diversity of niches in its human host. Aside from the classical manifestations of S. aureus-induced diseases, the pathogen also invades and survives within mammalian host cells. The survival strategies of the pathogen are as diverse as strains or host cell types used. S. aureus is able to replicate in the phagosome or freely in the cytoplasm of its host cells. It escapes the phagosome of professional and non-professional phagocytes, subverts autophagy, induces cellStaphylococcus aureus uses a plethora of virulence factors to accommodate a diversity of niches in its human host. Aside from the classical manifestations of S. aureus-induced diseases, the pathogen also invades and survives within mammalian host cells. The survival strategies of the pathogen are as diverse as strains or host cell types used. S. aureus is able to replicate in the phagosome or freely in the cytoplasm of its host cells. It escapes the phagosome of professional and non-professional phagocytes, subverts autophagy, induces cell death mechanisms such as apoptosis and pyronecrosis, and even can induce anti-apoptotic programs in phagocytes. The focus of this review is to present a guide to recent research outlining the variety of intracellular fates of S. aureus.…
Autor(en): | Martin Fraunholz, Bhanu Sinha |
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URN: | urn:nbn:de:bvb:20-opus-123374 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Frontiers in Cellular and Infection Microbiology |
Erscheinungsjahr: | 2012 |
Band / Jahrgang: | 2 |
Heft / Ausgabe: | 43 |
Originalveröffentlichung / Quelle: | Frontiers Cellular Infection Microbiology 2:43. doi:10.3389/fcimb.2012.00043 |
DOI: | https://doi.org/10.3389/fcimb.2012.00043 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 579 Mikroorganismen, Pilze, Algen |
Freie Schlagwort(e): | autophagy; bacterial persistence; host cell death; phagocytosis; phagosomalescape; staphylococcus aureus |
Datum der Freischaltung: | 18.12.2015 |
Lizenz (Deutsch): | CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell |