Interleukin-2-regulatory T cell axis critically regulates maintenance of hematopoietic stem cells
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-170947
- The role of IL-2 in HSC maintenance is unknown. Here we show that Il2\(^{−/-}\) mice develop severe anomalies in HSC maintenance leading to defective hematopoiesis. Whereas, lack of IL-2 signaling was detrimental for lympho- and erythropoiesis, myelopoiesis was enhanced in Il2\(^{−/-}\) mice. Investigation of the underlying mechanisms of dysregulated hematopoiesis in Il2\(^{−/-}\) mice shows that the IL-2-T\(_{reg}\) cell axis is indispensable for HSC maintenance and normal hematopoiesis. Lack of T\(_{reg}\) activity resulted in increased IFN-γThe role of IL-2 in HSC maintenance is unknown. Here we show that Il2\(^{−/-}\) mice develop severe anomalies in HSC maintenance leading to defective hematopoiesis. Whereas, lack of IL-2 signaling was detrimental for lympho- and erythropoiesis, myelopoiesis was enhanced in Il2\(^{−/-}\) mice. Investigation of the underlying mechanisms of dysregulated hematopoiesis in Il2\(^{−/-}\) mice shows that the IL-2-T\(_{reg}\) cell axis is indispensable for HSC maintenance and normal hematopoiesis. Lack of T\(_{reg}\) activity resulted in increased IFN-γ production by activated T cells and an expansion of the HSCs in the bone marrow (BM). Though, restoring T\(_{reg}\) population successfully rescued HSC maintenance in Il2\(^{-/-}\) mice, preventing IFN-γ activity could do the same even in the absence of T\(_{reg}\) cells. Our study suggests that equilibrium in IL-2 and IFN-γ activity is critical for steady state hematopoiesis, and in clinical conditions of BM failure, IL-2 or anti-IFN-γ treatment might help to restore hematopoiesis.…
Autor(en): | Sabrina Giampaolo, Gabriela Wójcik, Edgar Serfling, Amiya K. Patra |
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URN: | urn:nbn:de:bvb:20-opus-170947 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Pathologisches Institut |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Oncotarget |
Erscheinungsjahr: | 2017 |
Band / Jahrgang: | 8 |
Heft / Ausgabe: | 18 |
Seitenangabe: | 29625-29642 |
Originalveröffentlichung / Quelle: | Oncotarget, 2017, Vol. 8,, No. 18, 29625-29642. DOI: 10.18632/oncotarget.16377 |
DOI: | https://doi.org/10.18632/oncotarget.16377 |
PubMed-ID: | https://pubmed.ncbi.nlm.nih.gov/28415569 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten |
Freie Schlagwort(e): | IFN-γ; IL-10; IL-2; hematopoietic stem cells; immune response; immunity; immunology and microbiology section; treg cells |
Datum der Freischaltung: | 14.10.2019 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung |