- Treffer 1 von 1
Genomic Damage in Endstage Renal Disease - Contribution of Uremic Toxins
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-68653
- Patients with end-stage renal disease (ESRD), whether on conservative, peritoneal or hemodialysis therapy, have elevated genomic damage in peripheral blood lymphocytes and an increased cancer incidence, especially of the kidney. The damage is possibly due to accumulation of uremic toxins like advanced glycation endproducts or homocysteine. However, other endogenous substances with genotoxic properties, which are increased in ESRD, could be involved, such as the blood pressure regulating hormones angiotensin II and aldosterone or thePatients with end-stage renal disease (ESRD), whether on conservative, peritoneal or hemodialysis therapy, have elevated genomic damage in peripheral blood lymphocytes and an increased cancer incidence, especially of the kidney. The damage is possibly due to accumulation of uremic toxins like advanced glycation endproducts or homocysteine. However, other endogenous substances with genotoxic properties, which are increased in ESRD, could be involved, such as the blood pressure regulating hormones angiotensin II and aldosterone or the inflammatory cytokine TNF-. This review provides an overview of genomic damage observed in ESRD patients, focuses on possible underlying causes and shows modulations of the damage by modern dialysis strategies and vitamin upplementation.…
Autor(en): | Nicole Schupp, August Heidland, Helga Stopper |
---|---|
URN: | urn:nbn:de:bvb:20-opus-68653 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Pharmakologie und Toxikologie |
Sprache der Veröffentlichung: | Englisch |
Erscheinungsjahr: | 2010 |
Originalveröffentlichung / Quelle: | In: Toxins (2010) 2, 2340-2358, DOI: 10.3390/toxins2102340 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Normierte Schlagworte (GND): | Toxin |
Freie Schlagwort(e): | dialysis; genotoxicity; uremic toxins |
Datum der Freischaltung: | 12.11.2012 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung |