Blimp-1 Regulates Terminal Differentiation of T Cells
Regulation der terminalen Differenzierung von T-Zellen durch Blimp-1
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- The transcriptional repressor-Blimp-1 terminates differentiation of B lymphocytes as well as myeloid cells. Our data show that Blimp-1 is highly expressed in freshly isolated murine primary T lymphocytes, particularly its minor splice variant. Ectopic expression of Blimp-1 by retroviral transduction neither dramatically altered secretion of IFN-ã or IL-4 nor did it induce the ability to suppress as regulatory T cells. However, induction of Blimp-1 resulted in not only a significant reduction in the production of IL-2 but also an inability toThe transcriptional repressor-Blimp-1 terminates differentiation of B lymphocytes as well as myeloid cells. Our data show that Blimp-1 is highly expressed in freshly isolated murine primary T lymphocytes, particularly its minor splice variant. Ectopic expression of Blimp-1 by retroviral transduction neither dramatically altered secretion of IFN-ã or IL-4 nor did it induce the ability to suppress as regulatory T cells. However, induction of Blimp-1 resulted in not only a significant reduction in the production of IL-2 but also an inability to proliferate as well as in the reduced viability. These results demonstrate that Blimp-1 might mark end stages of lineage differentiation in T cells.…
Autor(en): | Zheng Xiao |
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URN: | urn:nbn:de:bvb:20-opus-10530 |
Dokumentart: | Dissertation |
Titelverleihende Fakultät: | Universität Würzburg, Medizinische Fakultät |
Institute der Universität: | Medizinische Fakultät / Institut für Virologie und Immunbiologie |
Datum der Abschlussprüfung: | 19.10.2004 |
Sprache der Veröffentlichung: | Englisch |
Erscheinungsjahr: | 2004 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Blimp-1; Regluation; T- Zelle Blimp-1; Regulation; T cell |
Datum der Freischaltung: | 18.11.2004 |
Betreuer: | Prof. Dr. Anneliese Schimpl |