Gastrointestinal epithelial innate immunity-regionalization and organoids as new model
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-265220
- The human gastrointestinal tract is in constant contact with microbial stimuli. Its barriers have to ensure co-existence with the commensal bacteria, while enabling surveillance of intruding pathogens. At the centre of the interaction lies the epithelial layer, which marks the boundaries of the body. It is equipped with a multitude of different innate immune sensors, such as Toll-like receptors, to mount inflammatory responses to microbes. Dysfunction of this intricate system results in inflammation-associated pathologies, such as inflammatoryThe human gastrointestinal tract is in constant contact with microbial stimuli. Its barriers have to ensure co-existence with the commensal bacteria, while enabling surveillance of intruding pathogens. At the centre of the interaction lies the epithelial layer, which marks the boundaries of the body. It is equipped with a multitude of different innate immune sensors, such as Toll-like receptors, to mount inflammatory responses to microbes. Dysfunction of this intricate system results in inflammation-associated pathologies, such as inflammatory bowel disease. However, the complexity of the cellular interactions, their molecular basis and their development remains poorly understood. In recent years, stem cell-derived organoids have gained increasing attention as promising models for both development and a broad range of pathologies, including infectious diseases. In addition, organoids enable the study of epithelial innate immunity in vitro. In this review, we focus on the gastrointestinal epithelial barrier and its regional organization to discuss innate immune sensing and development.…
Autor(en): | Özge Kayisoglu, Nicolas Schlegel, Sina Bartfeld |
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URN: | urn:nbn:de:bvb:20-opus-265220 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) |
Medizinische Fakultät / Institut für Molekulare Infektionsbiologie | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Journal of Molecular Medicine |
Erscheinungsjahr: | 2021 |
Band / Jahrgang: | 99 |
Heft / Ausgabe: | 4 |
Seitenangabe: | 517–530 |
Originalveröffentlichung / Quelle: | Journal of Molecular Medicine 2021, 99(4):517–530. DOI: 10.1007/s00109-021-02043-9 |
DOI: | https://doi.org/10.1007/s00109-021-02043-9 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | gastrointestinal tract; immunity; regionalization and organoids |
Datum der Freischaltung: | 11.04.2022 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |