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Optomotor-blind negatively regulates Drosophila eye development by blocking Jak/STAT signaling
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-143577
- Organ formation requires a delicate balance of positive and negative regulators. In Drosophila eye development, wingless (wg) is expressed at the lateral margins of the eye disc and serves to block retinal development. The T-box gene optomotor-blind (omb) is expressed in a similar pattern and is regulated by Wg. Omb mediates part of Wg activity in blocking eye development. Omb exerts its function primarily by blocking cell proliferation. These effects occur predominantly in the ventral margin. Our results suggest that the primary effect of OmbOrgan formation requires a delicate balance of positive and negative regulators. In Drosophila eye development, wingless (wg) is expressed at the lateral margins of the eye disc and serves to block retinal development. The T-box gene optomotor-blind (omb) is expressed in a similar pattern and is regulated by Wg. Omb mediates part of Wg activity in blocking eye development. Omb exerts its function primarily by blocking cell proliferation. These effects occur predominantly in the ventral margin. Our results suggest that the primary effect of Omb is the blocking of Jak/STAT signaling by repressing transcription of upd which encodes the Jak receptor ligand Unpaired.…
Autor(en): | Yu-Chen Tsai, Stefan Grimm, Ju-Lan Chao, Shih-Chin Wang, Kerstin Hofmeyer, Jie Shen, Fred Eichinger, Theoni Michalopoulou, Chi-Kuang Yao, Chih-Hsuan Chang, Shih-Han Lin, Y. Henry Sun, Gert O. Pflugfelder |
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URN: | urn:nbn:de:bvb:20-opus-143577 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | PLoS ONE |
Erscheinungsjahr: | 2015 |
Band / Jahrgang: | 10 |
Heft / Ausgabe: | 3 |
Seitenangabe: | e0120236 |
Originalveröffentlichung / Quelle: | PLoS ONE 10(3): e0120236 (2015). DOI: 10.1371/journal.pone.0120236 |
DOI: | https://doi.org/10.1371/journal.pone.0120236 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
Freie Schlagwort(e): | acts downstream; cell fate; compartment boundary; compound eye; gene expression; glial cells; imaginal disk; morphogenetic furrow progression; reporter gene; retinal differentiation |
Datum der Freischaltung: | 22.05.2018 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |