Probing the unknowns in cytokinin-mediated immune defense in Arabidopsis with systems biology approaches
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-120199
- Plant hormones involving salicylic acid (SA), jasmonic acid (JA), ethylene (Et), and auxin, gibberellins, and abscisic acid (ABA) are known to regulate host immune responses. However, plant hormone cytokinin has the potential to modulate defense signaling including SA and JA. It promotes plant pathogen and herbivore resistance; underlying mechanisms are still unknown. Using systems biology approaches, we unravel hub points of immune interaction mediated by cytokinin signaling in Arabidopsis. High-confidence Arabidopsis protein-proteinPlant hormones involving salicylic acid (SA), jasmonic acid (JA), ethylene (Et), and auxin, gibberellins, and abscisic acid (ABA) are known to regulate host immune responses. However, plant hormone cytokinin has the potential to modulate defense signaling including SA and JA. It promotes plant pathogen and herbivore resistance; underlying mechanisms are still unknown. Using systems biology approaches, we unravel hub points of immune interaction mediated by cytokinin signaling in Arabidopsis. High-confidence Arabidopsis protein-protein interactions (PPI) are coupled to changes in cytokinin-mediated gene expression. Nodes of the cellular interactome that are enriched in immune functions also reconstitute sub-networks. Topological analyses and their specific immunological relevance lead to the identification of functional hubs in cellular interactome. We discuss our identified immune hubs in light of an emerging model of cytokinin-mediated immune defense against pathogen infection in plants.…
Autor(en): | Muhammad Naseem, Meik Kunz, Thomas Dandekar |
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URN: | urn:nbn:de:bvb:20-opus-120199 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Bioinformatics and Biology Insights |
ISSN: | 1177-9322 |
Erscheinungsjahr: | 2014 |
Band / Jahrgang: | 8 |
Seitenangabe: | 35-44 |
Originalveröffentlichung / Quelle: | Bioinformatics and Biology Insights 2014:8 35–44 doi: 10.4137/BBI.S13462. |
DOI: | https://doi.org/10.4137/bbi.s13462 |
PubMed-ID: | https://pubmed.ncbi.nlm.nih.gov/24558299 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 572 Biochemie |
Freie Schlagwort(e): | cytokinin; gene expression; interaction networks; plant hormones; systems biology |
Datum der Freischaltung: | 11.02.2016 |
Lizenz (Deutsch): | CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell |