• search hit 2 of 2
Back to Result List

Reducing central serotonin in adulthood promotes hippocampal neurogenesis

Please always quote using this URN: urn:nbn:de:bvb:20-opus-168004
  • Chronic administration of selective serotonin reuptake inhibitors (SSRIs), which up-regulates central serotonin (5-HT) system function, enhances adult hippocampal neurogenesis. However, the relationship between central 5-HT system and adult neurogenesis has not fully been understood. Here, we report that lowering 5-HT level in adulthood is also able to enhance adult hippocampal neurogenesis. We used tamoxifen (TM)-induced Cre in Pet1-CreER\(^{T2}\) mice to either deplete central serotonergic (5-HTergic) neurons or inactivate 5-HT synthesis inChronic administration of selective serotonin reuptake inhibitors (SSRIs), which up-regulates central serotonin (5-HT) system function, enhances adult hippocampal neurogenesis. However, the relationship between central 5-HT system and adult neurogenesis has not fully been understood. Here, we report that lowering 5-HT level in adulthood is also able to enhance adult hippocampal neurogenesis. We used tamoxifen (TM)-induced Cre in Pet1-CreER\(^{T2}\) mice to either deplete central serotonergic (5-HTergic) neurons or inactivate 5-HT synthesis in adulthood and explore the role of central 5-HT in adult hippocampal neurogenesis. A dramatic increase in hippocampal neurogenesis is present in these two central 5-HT-deficient mice and it is largely prevented by administration of agonist for 5-HTR2c receptor. In addition, the survival of new-born neurons in the hippocampus is enhanced. Furthermore, the adult 5-HT-deficient mice showed reduced depression-like behaviors but enhanced contextual fear memory. These findings demonstrate that lowering central 5-HT function in adulthood can also enhance adult hippocampal neurogenesis, thus revealing a new aspect of central 5-HT in regulating adult neurogenesis.show moreshow less

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar Statistics
Metadaten
Author: Ning-Ning Song, Yun-Fang Jia, Lei Zhang, Qiong Zhang, Ying Huang, Xiao-Zhen Liu, Ling Hu, Wei Lan, Ling Chen, Klaus-Peter Lesch, Xiaoyan Chen, Lin Xu, Yu-Qiang Ding
URN:urn:nbn:de:bvb:20-opus-168004
Document Type:Journal article
Faculties:Medizinische Fakultät / Lehrstuhl für Molekulare Psychiatrie
Language:English
Parent Title (German):Scientific Reports
Year of Completion:2016
Volume:6
Issue:20338
Source:Scientific Reports 6:20338 (2016). DOI: 10.1038/srep20338
DOI:https://doi.org/10.1038/srep20338
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:SSRI; adulthood; hippocampal neurogenesis; serotonin
Release Date:2019/08/29
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International