Leaky gut as a potential culprit for the paradoxical dysglycemic response to gastric bypass-associated ileal microbiota

Please always quote using this URN: urn:nbn:de:bvb:20-opus-234085
  • Altered host-intestinal microbiota interactions are increasingly implicated in the metabolic benefits of Roux-en-Y gastric bypass (RYGB) surgery. We previously found, however, that RYGB-associated ileal microbiota can paradoxically impair host glycemic control when transferred to germ-free mice. Here we present complementary evidence suggesting that this could be due to the heightened development of systemic endotoxemia. Consistently, application of ileal content from RYGB-treated compared with sham-operated rats onto Caco-2 cell monolayersAltered host-intestinal microbiota interactions are increasingly implicated in the metabolic benefits of Roux-en-Y gastric bypass (RYGB) surgery. We previously found, however, that RYGB-associated ileal microbiota can paradoxically impair host glycemic control when transferred to germ-free mice. Here we present complementary evidence suggesting that this could be due to the heightened development of systemic endotoxemia. Consistently, application of ileal content from RYGB-treated compared with sham-operated rats onto Caco-2 cell monolayers compromised barrier function and decreased expression of the barrier-stabilizing proteins claudin-4 and desmoglein-2. Our findings raise the possibility that RYGB-associated ileal microbiota produce and release soluble metabolites which locally increase intestinal permeability to promote systemic endotoxemia-induced insulin resistance, with potential implications for the treatment of RYGB patients who eventually relapse onto type 2 diabetes.show moreshow less

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar Statistics
Metadaten
Author: Mohammed K. Hankir, Florian Seyfried, Isabel N. Schellinger, Nicolas Schlegel, Tulika Arora
URN:urn:nbn:de:bvb:20-opus-234085
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I)
Language:English
Parent Title (English):Metabolites
ISSN:2218-1989
Year of Completion:2021
Volume:11
Issue:3
Article Number:153
Source:Metabolites (2021) 11:3, 153. https://doi.org/10.3390/metabo11030153
DOI:https://doi.org/10.3390/metabo11030153
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Roux-en-Y gastric bypass surgery; intestinal epithelial barrier; intestinal microbiota; systemic endotoxemia; type 2 diabetes
Release Date:2022/08/12
Date of first Publication:2021/03/08
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International