Filtern
Volltext vorhanden
- ja (1) (entfernen)
Gehört zur Bibliographie
- ja (1)
Erscheinungsjahr
- 1994 (1) (entfernen)
Dokumenttyp
Sprache
- Englisch (1)
Schlagworte
- Physiologische Chemie (1) (entfernen)
Institut
The melanoma·inducing gene of Xiphophorus fish encodes the Xmrk receptor tyrosine kinase. U sing a highly specific antiserum p~oduced against the recombinant receptor expressed with a baculovirus, it is shown that Xmrk is the most abundant phosphotyrosine protein in fish melanoma and thus highly activated in the tumors. Studies on a melanoma cellline revealed that these cells produce an activity that considerably stimulates receptor autophosphorylation. The stimulating activity induces receptor down-regulation and can be depleted from the melanoma cellsupernatant by the immobilized recombinant receptor protein. The fish melanoma cells can thus be considered autocrine tumor cells providing a source for future purification and characterization of the Xmrk ligand.