TY  - JOUR
A1  - Hu, Chen
A1  - Hahn, Lukas
A1  - Yang, Mengshi
A1  - Altmann, Alexander
A1  - Stahlhut, Philipp
A1  - Groll, Jürgen
A1  - Luxenhofer, Robert
T1  - Improving printability of a thermoresponsive hydrogel biomaterial ink by nanoclay addition
T2  - Journal of Materials Science
N2  - As a promising biofabrication technology, extrusion-based bioprinting has gained significant attention in the last decade and major advances have been made in the development of bioinks. However, suitable synthetic and stimuli-responsive bioinks are underrepresented in this context. In this work, we described a hybrid system of nanoclay Laponite XLG and thermoresponsive block copolymer poly(2-methyl-2-oxazoline)-b-poly(2-n-propyl-2-oxazine) (PMeOx-b-PnPrOzi) as a novel biomaterial ink and discussed its critical properties relevant for extrusion-based bioprinting, including viscoelastic properties and printability. The hybrid hydrogel retains the thermogelling properties but is strengthened by the added clay (over 5 kPa of storage modulus and 240 Pa of yield stress). Importantly, the shear-thinning character is further enhanced, which, in combination with very rapid viscosity recovery (~ 1 s) and structure recovery (~ 10 s), is highly beneficial for extrusion-based 3D printing. Accordingly, various 3D patterns could be printed with markedly enhanced resolution and shape fidelity compared to the biomaterial ink without added clay.
KW  - printability
KW  - thermoresponsive hydrogel
Y1  - 2021
UR  - https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/frontdoor/index/index/docId/23489
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-234894
SN  - 0022-2461
VL  - 56
ER  -