TY  - JOUR
A1  - Straub, Tobias
A1  - Freudenberg, Marina A.
A1  - Schleicher, Ulrike
A1  - Bogdan, Christian
A1  - Gasteiger, Georg
A1  - Pircher, Hanspeter
T1  - Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells
T2  - Nature Communications
N2  - Infection of specific pathogen-free mice with lymphocytic choriomeningitis virus (LCMV) is a widely used model to study antiviral T-cell immunity. Infections in the real world, however, are often accompanied by coinfections with unrelated pathogens. Here we show that in mice, systemic coinfection with E. coli suppresses the LCMV-specific cytotoxic T-lymphocyte (CTL) response and virus elimination in a NK cell- and TLR2/4-dependent manner. Soluble TLR4 ligand LPS also induces NK cell-mediated negative CTL regulation during LCMV infection. NK cells in LPS-treated mice suppress clonal expansion of LCMV-specific CTLs by a NKG2D- or NCR1-independent but perforin-dependent mechanism. These results suggest a TLR4-mediated immunoregulatory role of NK cells during viral-bacterial coinfections.
KW  - Bacterial infection
KW  - infection
KW  - lymphocyte activation
KW  - viral infection
Y1  - 2018
UR  - https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/frontdoor/index/index/docId/24007
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-240075
VL  - 9
ER  -