TY  - JOUR
A1  - Kunzmann, Steffen
A1  - Krempl, Christine
A1  - Seidenspinner, Silvia
A1  - Glaser, Kirsten
A1  - Speer, Christian P.
A1  - Fehrholz, Markus
T1  - Increase in CTGF mRNA expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells
T2  - Influenza and Other Respiratory Viruses
N2  - Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in early childhood. Underlying pathomechanisms of elevated pulmonary morbidity in later infancy are largely unknown. We found that RSV-infected H441 cells showed increased mRNA expression of connective tissue growth factor (CTGF), a key factor in airway remodeling. Additional dexamethasone treatment led to further elevated mRNA levels, indicating additive effects. Caffeine treatment prevented RSV-mediated increase in CTGF mRNA. RSV may be involved in airway remodeling processes by increasing CTGF mRNA expression. Caffeine might abrogate these negative effects and thereby help to restore lung homeostasis.
KW  - caffeine
KW  - CCN2
KW  - dexamethasone
KW  - lung remodeling
KW  - poly(I:C)
Y1  - 2018
UR  - https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/frontdoor/index/index/docId/23090
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-230909
VL  - 12
ER  -