TY  - JOUR
A1  - Jaggi, W.
A1  - Lutz, Werner K.
A1  - Schlatter, C.
T1  - Covalent binding of ethinylestradiol and estrone to rat liver DNA in vivo
N2  - Thecovalent bindingof [6,7-\(^3\)H]ethinylestradiol (EE)and [6,7-\(^3\)H]estrone (E) to liver DNA of 200 g female ratswas measured 8 h after the administration of 80 \(\mu\)g (9.2 mCi) estrogen by gavage. The binding is 1.5 for EE and 1.1 for E, expressedas binding to DNA/dose, in units of \(\mu\)mol hormonefmol DNA phosphate/mmole honnone/kg body wt. It is in the same order of magnitude as for benzene and about 10 000 tim es below the binding of typical liver carcinogens, such as aflatoxin B\(_1\) or N,N-dimethylnitrosamine.
KW  - Toxikologie
Y1  - 1978
UR  - https://opus.bibliothek.uni-wuerzburg.de/opus4-wuerzburg/frontdoor/index/index/docId/5502
UR  - https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-61162
ER  -