@article{UlrichsMuellerRuchholtz1990,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Mixed lymphocyte islet culture (MLIC) and its use in manipulation of human islet alloimmunogenicity},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45515},
  year      = {1990},
  abstract  = {No abstract available},
  language  = {en}
}
@article{UlrichsKuhlencordtMuellerRuchholtz1979,
  author    = {Ulrichs, Karin and Kuhlencordt, KM and M{\"u}ller-Ruchholtz, W.},
  title     = {Plating inhibition assay (PIA): a new test for cell mediated cytotoxicity},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45443},
  year      = {1979},
  abstract  = {No abstract available},
  language  = {en}
}
@article{UlrichsDeltzThiedeetal.1982,
  author    = {Ulrichs, Karin and Deltz, E. and Thiede, A. and M{\"u}ller-Ruchholtz, W.},
  title     = {Lymphoid tissue transplantation in rats leads to a GVHR, inducing a specific T-cell mediated autoreactivity against MHC-antigens},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45420},
  year      = {1982},
  abstract  = {No abstract available},
  language  = {en}
}
@article{UlrichsMuellerBuchholtz1985,
  author    = {Ulrichs, Karin and M{\"u}ller-Buchholtz, W.},
  title     = {MHC class II antigen expression on the various cells of normal and activated isolated pancreatic islets},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44722},
  year      = {1985},
  abstract  = {It is the aim of this study to characterize and quantify the cells within isolated rat islets that express MHC class 11 antigens. A set of five monoelonal antibodies and two polyclonal antisera of defined specificlty were used in combination with a newly devised procedure for three·dimensional immunofluorescence evaluation of intact islets. It is shown that in addition to passen· ger cells, such as Iymphocytes, macro· phages, and dendrlticlike cells, vascular endothelial and endocrine cells are also capable of expressing class 11 antigens. This expression Is strongly influenced by in vitro culture. pregnancy, streptozotocin- induced diabetes, transplantation trauma, and alloantigenic stimuli. The pos· sible role of the above cells in antigen presentation related to islet transplantation is discussed.},
  language  = {en}
}
@article{UlrichsSchangKelleretal.1984,
  author    = {Ulrichs, Karin and Schang, T. and Keller, R. and M{\"u}ller-Ruchholtz, W.},
  title     = {Reactivity of pancreas islet cells with antisera of known specificity},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45466},
  year      = {1984},
  abstract  = {No abstract available},
  language  = {en}
}
@article{EngemannGasselUlrichsetal.1986,
  author    = {Engemann, R. and Gassel, HJ and Ulrichs, Karin and Thiede, A. and Hamelmann, H.},
  title     = {Suppressorzellmechanismen nach Cyclosporin A (CsA) induzierter Toleranz allogener Rattenlebertransplantate},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45503},
  year      = {1986},
  abstract  = {No abstract available},
  language  = {de}
}
@article{HeiserUlrichsMuellerRuchholtz1994,
  author    = {Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Prophylactic trypsin inhibition during the isolation procedure guarantees reproducible, high porcine islet yields},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45531},
  year      = {1994},
  abstract  = {Abstract: For isolating islets from the porcine pancreas, we established a semiautomated digestion method. Although the isolation technique was standardized and collagenase of controlled quality was used, until now the reproducibility of high islet yields was unsatisfactory. Our hypothesis was that pancreatic trypsin was responsible for this failure. The aim of this study was to investigate the effect of endogenous trypsin on islet yield. Our results demonstrate that a high trypsin level correlates with poor islet yield, whereas low trypsin activity always correlates with high islet yield. Specific inhibition of trypsin results in low trypsin activity and reproducible, high islet yields.},
  language  = {en}
}
@article{EngemannUlrichsThiedeetal.1990,
  author    = {Engemann, R. and Ulrichs, Karin and Thiede, A. and M{\"u}ller-Ruchholtz, W. and Hamelmann, H.},
  title     = {Value of a physiological liver transplant model in rats. Induction of specific graft tolerance in a fully allogeneic strain combination},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45622},
  year      = {1990},
  abstract  = {No abstract available},
  language  = {en}
}
@article{UlrichsYuDunckeretal.1984,
  author    = {Ulrichs, Karin and Yu, MY and Duncker, D. and M{\"u}ller-Ruchholtz, W.},
  title     = {Immunosuppression by cytostatic drugs?},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45574},
  year      = {1984},
  abstract  = {In the present study, an attempt was made to characterize the immunomodulating abilities of the cytostatic drugs cydophosphamide, ifosfamide, vinblastine, vincristine, procarbazine, dacarbazine, 6-mercaptopurine, methotrexate, 5-f/uor-uracil and adriamycine in a defined experimental model. Varying combinations of drug plus transplantation alloantigen, (C3H-lymphocytes) were injected into Balb/c mice at different time intervals in vivo. The resulting T-effector cell reactivity was determined in vitro with the microcytotoxicity assay on day + 5 for primary (r) and day + 7 for secondary (2°) sensitized mice. According to the type of drug (alkylating agent vs. vinca alkaloid vs. antimetabolite vs. cytostatic antibiotic), the dosage (20\% LD50 vs. 60\% LD50), the state of sensitization (r vs. 2° sensitized recipients), and the time of drug application in relation to the antigen treatment on day 0 (in varying steps from day -6 to day +4), so-called "pharmaconantigen- variation-effects" (PA VE) were established for each of the investigated drugs in form of reaction profiles. The results were as folIows: (1) For almost alt substances, characteristic reaction profiles involving immunostimulation and/or immunosuppression could be established. Similarities in the profiles of different substances made it possible to classify the drugs according to different reaction types. The reaction type however is not definitely correlated to the biochemical mechanism of drug action. (2) The PA VE are decisively inf/uenced by so me of the biological parameters, such as the time of drug application in relation to the antigen treatment and the state of sensitization but relatively !ittle by the dosage of the drug. (3) Considering the different processes occurring du ring primary and secondary immune responses, the PAVE may give hints for a distinct manipulation of the immunoregulation and thus information on the immunobiological mechanism of drug action.},
  subject      = {Immunologie},
  language  = {en}
}
@inproceedings{KaitschickUlrichsMuellerRuchholtz1991,
  author    = {Kaitschick, J. and Ulrichs, K. and M{\"u}ller-Ruchholtz, W.},
  title     = {The New Immunosuppressant Leflunomide Appears To Be a Potent Inhibitor of Humoral Xeno Sensitization},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45727},
  year      = {1991},
  abstract  = {No abstract available},
  subject      = {Immunbiologie},
  language  = {en}
}