@article{ZvirblisGorboulevRubtsovetal.1988,
  author    = {Zvirblis, G. S. and Gorboulev, Valentin G. and Rubtsov, P. M. and Chernov, B. K. and Golova, Yu. B. and Pozmogova, G. E. and Skryabin, K. G. and Bayev, A. A.},
  title     = {Genetic engineering of peptide hormones : III. Cloning of cDNA of porcine growth hormone and construction of gene for expression of hormone in bacteria},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-46958},
  year      = {1988},
  abstract  = {Results are presented of cloning cDNA of procine growth hormone, analysis of its primary structure, and creation of a construction capable of expression of this cDNA in Esqheriahia coti cells. It is shown that in the population of mRNA coding porcine growth hormone, heterogeneity is noted which is manifested not only at the level of the nucleotide sequence, but also is reflected in the amino acid sequence of the mature hormone.},
  language  = {en}
}
@article{WirbelauerHofHacker1988,
  author    = {Wirbelauer, J. and Hof, H. and Hacker, J{\"o}rg},
  title     = {Die Wirkung von Desacetylcefotaxin, einem Metaboliten von Cefotaxim, in vitro und auf die experimentelle Infektion mit Escherichia coli},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40348},
  year      = {1988},
  abstract  = {Die MHK-Werte von Desacetylcefotaxim gegen verschiedene, z. T. ampicillinresistente St{\"a}mme von Escherichia coH, die mit Hilfe einer Agardilutionsmethode erhoben wurden, waren h{\"o}her als die von Cefotaxim und Ceftriaxon, jedoch niedriger als die von Cefoxitin. In einem Modell der systemischen Infektion der Maus mit einem plasmidtragenden, betalactamaseproduzierenden Stamm von E. coli f{\"u}hrte die Therapie mit Desacetylcefotaxim zu einer starken Reduktion der Keime pro Leber. Im Vergleich zur Therapie mit Cefotaxim trat die protektive Wirkung aber verlangsamt ein. Desacetylcefotaxim ist also kein unn{\"u}tzes Abbauprodukt von Cefotaxim.},
  language  = {de}
}
@article{WinotoMorbachLeyhausenMuellerRuchholtzetal.1988,
  author    = {Winoto-Morbach, S. and Leyhausen, G. and M{\"u}ller-Ruchholtz, W. and Ulrichs, Karin},
  title     = {The Electromagnetic Separation Principle: A Basis for Human Pancreatic Islet Transplantation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82520},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Allergie},
  language  = {en}
}
@article{Wilhelm1988,
  author    = {Wilhelm, Gernot},
  title     = {K Churritskoj i urartskoj grammatikje},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82984},
  year      = {1988},
  abstract  = {No Abstract available},
  language  = {ru}
}
@incollection{Wilhelm1988,
  author    = {Wilhelm, Gernot},
  title     = {Zur ersten Zeile des Šunaššura-Vertrages},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72337},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {No abstract available.},
  language  = {de}
}
@article{Wilhelm1988,
  author    = {Wilhelm, Gernot},
  title     = {Neue akkadische Gilgameš-Fragmente aus Hattusa},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87718},
  year      = {1988},
  abstract  = {No abstract available.},
  subject      = {Gilgameschichtung},
  language  = {de}
}
@article{Wilhelm1988,
  author    = {Wilhelm, Gernot},
  title     = {Zu den Wollmaßen in Nuzi},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87792},
  year      = {1988},
  abstract  = {no Abstract available},
  subject      = {Nuzi},
  language  = {de}
}
@incollection{Wilhelm1988,
  author    = {Wilhelm, Gernot},
  title     = {Gedanken zur Fr{\"u}hgeschichte der Hurriter und zum hurritisch-urart{\"a}ischen Sprachvergleich},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87728},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {No abstract available.},
  subject      = {Geschichte},
  language  = {de}
}
@incollection{WeinertSchneiderKnopf1988,
  author    = {Weinert, Franz E. and Schneider, Wolfgang and Knopf, Monika},
  title     = {Individual differences in memory development across the life-span},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-70666},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {Experimental research on memory development has typically focused on the description of universal development trends across the life span and the identification of major sources of development within this domain. However, there is a lack of studies investigating the preconditions and effects of interindividual variability within age groups across different memory tasks. Similarly, our knowledge about the stability of interindividual differences across the life span as well as the sources and the amount of intraindividual variability across memory tasks is scarce. In the present chapter, we concentrate on these neglected issues. First, theoretical assumptions concerning the interindividual and intraindividual variability of memory development are discussed. Next, empirical evidence is presented that seems suited to document the importance of these neglected issues. While we try to give a representative account of the literature, the emphasis is on more recent studies of memory development in children and elderly adults conducted in our laboratory. The results demonstrate that age-related changes and individual differences in the knowledge base are particularly important for describing and explaining individual differences in memory develoment. In comparison, the rote of stable individual differences in basic memory capacities in explaining variations in memory development is less clear given tbe conflicting empirical evidence. In the final section of the chapter consequences for future research are discussed.},
  subject      = {Ged{\"a}chtnisbildung},
  language  = {en}
}
@inproceedings{WeinertSchneiderAsendorpfetal.1988,
  author    = {Weinert, Franz E. and Schneider, Wolfgang and Asendorpf, Jens and Helmke, Andreas and Knopf, Monika and Kuhl, Julius and Nunner-Winkler, Gertrud and Strube, Gerhard},
  title     = {Entwicklung im Vorschulalter: Bericht {\"u}ber eine L{\"a}ngsschnittstudie},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86699},
  year      = {1988},
  abstract  = {Dargestellt werden die theoretischen Ziele, das methodische Vorgehen und die ersten Ergebnisse einer Longitudinalstudie zur Genese individueller Kompetenzen (LOGIK) im Vorschulalter. Dabei geht es vor allem um generelle Merkmale und differentielle Verl{\"a}ufe bei der Entwicklung kognitiver, sozialer und motivationaler Kompetenzen.},
  subject      = {Vorschulkind},
  language  = {de}
}
@inproceedings{Wehgartner1988,
  author    = {Wehgartner, Irma},
  title     = {Neue Untersuchungen zur weißgrundigen Lekythenbemalung},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-53807},
  year      = {1988},
  abstract  = {no abstract available},
  subject      = {Lekythenbemalung},
  language  = {de}
}
@article{Wehgartner1988,
  author    = {Wehgartner, Irma},
  title     = {Eine neue "pontische" Oinochoe und {\"U}berlegungen zur Genese ihrer Form},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87561},
  year      = {1988},
  abstract  = {Das Martin-von-Wagner-Museum besitzt eine seit langem bekannte Sammlung bedeutender 'pontischer' Vasen, die vor kurzem durch die Erwerbung einer Oinochoe dieser Gattung sinnvoll erg{\"a}nzt werden konnte (Abb. 30-34. 38. 40-45). Denn obwohl in der 'pontischen' Keramik die Oinochoen nach den Amphoren die h{\"a}ufigste Gef{\"a}ßform sind, war gerade diese Form in der W{\"u}rzburger Sammlung bisher nur durch zwei kleine, atypische Exemplare vertreten gewesen. Die neu erworbene Oinochoe kann dagegen nach ihrer Gr{\"o}ße, ihren Formmerkmalen und ihrer Bemalung als eine typische Vertreterio dieser Form innerhalb der 'pontischen' Gattung gelten.},
  subject      = {Martin-von-Wagner-Museum / Antikenabteilung},
  language  = {de}
}
@article{VollmerEllgring1988,
  author    = {Vollmer, Heinz C. and Ellgring, Johann Heinrich},
  title     = {Die Vorhersage der vorzeitigen Therapiebeendigung bei Drogenabh{\"a}ngigen},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42069},
  year      = {1988},
  abstract  = {In zwei Therapieeinrichtungen zur Drogen-Entw{\"o}hnungsbehandlung wurde bei 194 Dro- , genabh{\"a}ngigen untersucht, inwiefern Anamnesedaten und Pers{\"o}nlichkeits variablen eine Vorhersage der vorzeitigen Therapiebeendigung gestatten. Lediglich eine Variable wies f{\"u}r Patienten beider Behandlungseinrichtungen gleichermaßen prognostische Valenz auf: Patienten mit gerichtlicher Auflage schlossen die Therapie h{\"a}ufiger regul{\"a}r ab als Patienten ohne Auflage. Oie Art der gerichtlichen Auflage oder auch die Dauer der noch ausstehenden Strafzeit korrelierten dagegen nicht mit der Art der Therapiebeendigung. Ansonsten gab es f{\"u}r beide Therapieeinrichtungen und f{\"u}r die verschiedenen Arten der vorzeitigen Beendigung (Entlassung bzw. Abbruch) unterschiedliche, manchmal auch entgegengesetzte, prognostische Kriterien. Ein Patient, der in einer Einrichtung abbruchgef{\"a}hrdet ist, kann in einer anderen Einrichtung gute Chancen haben, die Behandlung regul{\"a}r abzuschließen. Aus der Literatur bekannte Kriterien wie zum Beispiel Alter und Schulbildung zeigten in dieser Studie nur in Abh{\"a}ngigkeit von der Einrichtung prognostische Valenz und dies spezifisch f{\"u}r Abbruch bzw. vorzeitige Entlassung. Andere Pr{\"a}diktoren wie Geschlecht, psychische Auff{\"a}lligkeiten und Depression korrelierten {\"u}berhaupt nicht mit vorzeitiger Therapiebeendigung. Auch Patienten, die zu Beginn der Therapie als gering motiviert einzustufen sind, haben gute Chancen, die Behandlung regul{\"a}r abzuschließen. Auf der Grundlage einer Diskriminanzanalyse der FPI-Items war eine vorzeitige Entlassung besser vorhersag bar als ein Therapieabbruch. Nach den Daten dieser Studie ist zu vermuten, daß bestimmte Kombinationen von Einrichtungs-, Therapeuten- und Patienten variablen einen Einfluß auf die Art der Therapiebeendigung haben.},
  language  = {de}
}
@article{UlrichsMuellerRuchholtz1988,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Expression of MHC Structures on Immunologically Reactive and Non Reactive Cells in Islets of Langerhans and Other Tissues},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45557},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{ThiryScheerGoessens1988,
  author    = {Thiry, Marc and Scheer, Ulrich and Goessens, Guy},
  title     = {Immunoelectron microscopic study of nucleolar DNA during mitosis in Ehrlich tumour cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40745},
  year      = {1988},
  abstract  = {In order to investigate the DNA localization within Ehrlich tumor cell nucleoli during mitosis, two recent immunocytochemical methods using either an anti-DNA or an anti-bromodeoxyuridine (BrdU) monoclonal antibody have been applied. In both cases, the immunogold labeling has been performed on ultrathin sections of cells embedded either in Lowicryl K4M or in Epon, respectively. Identical results are observed with both immunocytochemical approaches. In the interphase nucleolus, besides the labeling of the perinucleolar chromatin shell and of its intranucleolar invaginations which penetrate into the nucleolar body and often terminate at the fibrillar centers, a few gold particles are also preferentially found towards the peripheral region of the fibrillar centers. In contrast, the dense fibrillar component and the granular component are never labeled. During mitosis, the fibrillar centers persist at the chromosomal nucleolus organizing regions (NOR's) and can be selectively stained by the silver method. However, these metaphase fibrillar centers are no longer decorated by the DNA- or BrdU antibodies. These results indicate that until the end of prophase, rRNA genes are present inside the fibrillar center material, disappear during metaphase and reappear in reconstituting nucleoli during telophase. Thus, fibrillar centers appear to represent structures sui generis, which are populated by rRNA genes only when the nucleolus is functionally active. In segregated nucleoli after actinomycin D treatment, the DNA labeling is exclusively restricted to the perinucleolar chromatin blocks. These findings also suggest that the DNA content of the fibrillar center material varies according to the rRNA transcription level of the cells. The results are discussed in the light of the present knowledge of the functional organization of the nucleolus.},
  subject      = {Cytologie},
  language  = {en}
}
@article{ThiryScheerGoessens1988,
  author    = {Thiry, Marc and Scheer, Ulrich and Goessens, Guy},
  title     = {Localization of DNA within Ehrlich tumour cells nucleoli by immunoelectron microscopy},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39327},
  year      = {1988},
  abstract  = {The distribution of DNA in Ehrlich tumour cell nucleoli was investigated by means of an immunocytochemical approach , involving a monoclonal antibody directed against double- and single-stranded DNA. Immunolabelling was performed . either before or after the embedding process. The postembedding labelling method allows better ultrastructural preservation than the preembedding labelling method. In particular, the various nucleolar components are well preserved and identifiable. In the nucleolus, labelling is particularly concentrated over the perinucleolar chromatin and over its intranucleolar invaginations, which penetrate the nucleolar body and often terminate at the fibrillar centres. In addition, aggregates of gold particles are found in the fibrillar centres, preferentially towards the peripheral regions. By contrast, the dense fibrillar component is completely devoid of labelling. The results seem to indicate that DNA containing the rDNA genes is located in the fibrillar centres, with a preference for the peripheral regions. This finding suggests that transcription of the rDNA genes should occur within the confines of the fibrillar centre, probably close to the boundary region of the surrounding dense fibrillar component. The results are discussed in the light of present knowledge of the functional organization of the nucleolus.},
  language  = {en}
}
@article{TackeRohrAehle1988,
  author    = {Tacke, Reinhold and Rohr-Aehle, R.},
  title     = {Ester des (Hydroxymethyl)[(trimethylsilyl)methyl]silans: Synthese und thermisch induzierte Umlagerung},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63889},
  year      = {1988},
  abstract  = {Die Synthese des (Hydroxymethyl)[(trimethylsilyl)methyl]silans (3) sowie des hiervon abzuleitenden Acetats 4 und Chlorformiats 6 wird beschrieben. 4 und 6 unterliegen einer thermisch induzierten Umwandlung zu den difunktionellen Silanen 5 bzw. 8. Die Umwandlungen 4 -> 5 und 6 -> 8 erfolgen gem{\"a}ß einer Kinetik 1. Ordnung mit Halbwertszeiten von 10.0 bzw. 3.6 h (135 ° C, in C\(_6\)D\(_6\)).},
  subject      = {Anorganische Chemie},
  language  = {de}
}
@article{TackeBecker1988,
  author    = {Tacke, Reinhold and Becker, B.},
  title     = {Synthese und Eigenschaften von (Hydroxymethyl)dimethylgerman und (Hydroxymethyl)diphenylgerman},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63895},
  year      = {1988},
  abstract  = {Die (Hydroxymethyl)diorganylgermane (CH\(_3\))\(_2\)Ge(H)CH\(_2\)OH und (C\(_6\)H\(_5\))\(_2\)Ge(H)CH\(_2\)OH wurden - ausgehend von GeCl\(_4\) - durch eine jeweils vierstufige Synthese mit einer Gesamtausbeute von 15 bzw. 32\% dargestellt (GeCl\(_4\) ---+ Cl\(_3\)GeCH\(_2\)Cl -> R \(_2\)Ge(Cl)CH \(_2\)Cl ->R \(_2\)Ge(OAc)CH\(_2\)OAc--) R \(_2\)Ge(H)CH\(_2\)OH; R = CH\(_3\) bzw. C\(_6\)H\(_5\) ). Die chemische Reaktivit{\"a}t der Germane (CH\(_3\))\(_2\)Ge(H)CH\(_2\)OH und (C\(_6\)H\(_5\))\(_2\)Ge(H)CH\(_2\)OH wird durch deren Ge-H- und 0-H-Bindung bestimmt.},
  subject      = {Anorganische Chemie},
  language  = {de}
}
@article{SyldatkStoffregenWuttkeetal.1988,
  author    = {Syldatk, C. and Stoffregen, A. and Wuttke, F. and Tacke, Reinhold},
  title     = {Enantioselective reduction of acetyldimethylphenylsilane: a screening with thirty strains of microorganisms},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63906},
  year      = {1988},
  abstract  = {Thirty strains of microorganisms (bacteria, yeasts, fungi and green algae) were tested as resting free cells for their ability to transform acetyldimethylphenylsilane (1) enantioselectively into (R)-(1-hydroxyethyl) dimethylphenylsilane [(R)-2]. The biotransformations were monitared by GC (packed OV-17 column), and the enantiomeric purities of the products isolated were determined by HPLC (cellulose triacetate column, UV detection). All microorganisms tested were found to reduce 1 enantioselectively to give (R)-2. Under the test conditions used, the yeast Trigonapsis variabilis (DSM 70714) was found to 1 exhibif the highest specific activity (1.5 mg product x g cell wet mass\(^{-1}\) x min\(^{-1}\) ), whereas the highest enantioselectivities were observed for the bacteria Acinetobacter ca lcoaceticus (ATCC 31012) (>95\% ee), Brevfbacterium species (ATCC 21860) (90\% ee) and Corynebacterium dioxydans (ATCC 21766) (>95\% ee), the yeast Candida humico la (OSM 70067) (90\% ee), the fungus Cunninghame lla e legans (ATCC 26269) (94\% ee), as well as the cyanobacterium Synechococcus leopoliensis (94\% ee).· From the green algae tested, Chlamydomonas reinhardii showed the highest.enantioselectivity (85\% ee).},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{StopperZimmermannNeil1988,
  author    = {Stopper, Helga and Zimmermann, U. and Neil, G. A.},
  title     = {Increased efficiency of transfection of murine hybridoma cells with DNA by electropermeabilization},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63488},
  year      = {1988},
  abstract  = {Dispase-treated murine hybridoma cells (SP2/0-Ag14) were transfected with the G418 resistance gene bearing plasmid pSV2-neo by electropermeabilization with a high degree of efficiency. The cells were subjected to intermittent multiple high-voltage short duration (5 p.s) DC pulses at intervals of 1 min in a weakly conducting medium followed by selection in G418-containing medium. The transfection medium, temperature, pulse duration, and voltage were empirically determined by preliminary electropermeabilization experiments. Increasing the number of pulses resulted in a higher percentage of transfected cells, but a decrease in the number of viable cells, with the optimal transfectant yield resulting when five pulses of 10 kV jcm were administered. This method allows the rapid and efficient injection of DNA into mammalian cells, and permits the rapid production of stable, drug resistant hybridoma celllines for use in subsequent fusion experiments.},
  subject      = {Toxikologie},
  language  = {en}
}
@article{Sponholz1988,
  author    = {Sponholz, Barbara},
  title     = {Beobachtungen zur Morphodynamik an Koris des s{\"u}dlichen Air-Vorlandes (Niger)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-53579},
  year      = {1988},
  abstract  = {Am Beispiel von vier Koris l) (T{\´e}loua, Barghot, Tazol{\´e}, Oufagu{\´e}dout) des s{\"u}dlichen Air-Vorlandes werden Beobachtungen zum aktuellen morphodynamischen Geschehen dieser Region vorgestellt. Durch die regionalen Unterschiede der durchschnittlichen j{\"a}hrlichen Niederschlagsh{\"o}hen und durch unterschiedliche Charakteristika ihrer Einzugsgebiete k{\"o}nnen diese vier Koris als typische Vertreter verschiedener fluviatil/{\"a}olischer Formungsgruppen angesehen werden. Der {\"U}bergang von vorherrschend fluviatiler zu vorherrschend {\"a}olischer Formung liegt dabei im Bereich des Kori Oufagu{\´e}dout, im {\"o}stlichen Teil des Untersuchungsraumes. Hier konnte durch mehrere Sch{\"u}rfe auch der zeitliche {\"U}bergang zwischen beiden Formungskreisen in der j{\"u}ngeren Reliefgeschichte nachgewiesen werden.},
  subject      = {Geographie},
  language  = {de}
}
@phdthesis{Sponholz1988,
  author    = {Sponholz, Barbara},
  title     = {Karsterscheinungen in nichtkarbonatischen Gesteinen der {\"o}stlichen Republik Niger},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-55474},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {Das Arbeitsgebiet mit den im einzelnen untersuchten Regionen umfaßt ungef{\"a}hr die {\"o}stliche H{\"a}lfte der Republik Niger. Es erstreckt sich zwischen 8° (Agadez) und 13° (Stufe von Bilma) {\"o}stlicher L{\"a}nge und zwischen 13°40° und 21° n{\"o}rdlicher Breite. Dabei umfaßt es eine Fl{\"a}che von insgesamt rund 440.000 km2. Administrativ sind die untersuchten Teilregionen den Departements Agadez und Zinder zugeordnet. Der Untersuchungsraum wird von wenigen geologisch-tektonischen Großeinheiten aufgebaut, die ihren Niederschlag auch in der morphologischen Auspr{\"a}gung finden: Der Hauptteil des Arbeitsgebietes geh{\"o}rt dem geologisch-hydrologischen Tschadbecken an, zu dem auch das n{\"o}rdlich anschließende Becken von Bilma gerechnet werden kann. Das im Nordosten des Untersuchungsraumes gelegene Djado-Becken wird randlich erfaßt. Bis auf wenige Ausnahmen ist dieser Raum von weitgespannten Ebenheiten gepr{\"a}gt, die teilweise als Serirfl{\"a}chen entwickelt sind, teilweise aber auch von den Sandmassen des Erg du Tenere und des Grand Erg de Bilma {\"u}berdeckt werden. Die darin inselhaft aufragenden Schichtstufenkomplexe lehnen sich an grob NW-SE-gerichtete St{\"o}rungszonen an. Die geologisch-morphologische Umrahmung des Arbeitsgebietes bilden die Hebungsgebiete des Air, des Tibesti (bereits außerhalb des Untersuchungsraumes im Tschad gelegen) und des Damagaram/Mounio. Die Gebirgsmassive erreichen H{\"o}hen bis knapp 3.300 m {\"u}.NN (Tibesti) bzw. um 2.000 m {\"u}.NN (Air), w{\"a}hrend das dazwischen liegende Tenere bei etwa 400 m {\"u}.NN (im S{\"u}den) bis 500 m {\"u}.NN (im Norden) entwickelt ist. Nach naturr{\"a}umlichen Gesichtspunkten gegliedert hat der Untersuchungsraum sowohl Anteil an der s{\"u}dlichen zentralen und der s{\"u}dlichen Sahara als auch am n{\"o}rdlichen Sahel. Innerhalb dieses Gesamtraumes konzentrieren sich die hier vorgestellten Untersuchungen auf mehrere Teilgebiete. Von Norden nach S{\"u}den sind dies das s{\"u}dwestliche Djado, die Stufe von Bilma mit dem Kaouar, die Massive von Termit und Koutous, sowie weiter westlich gelegen die Stufe von Tiguidit etwa 80 km s{\"u}dlich des Air. Einzelbeobachtungen aus dem Kristallin des Air und des Damagaram/Mounio erg{\"a}nzen die Untersuchungen.},
  subject      = {Karst},
  language  = {de}
}
@article{SirenLettsFeuerstein1988,
  author    = {Sir{\´e}n, Anna-Leena and Letts, G. and Feuerstein, G.},
  title     = {N-Acetyl-leukotriene E\(_4\) is a potent constrictor of rat mesenteric vessels},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63196},
  year      = {1988},
  abstract  = {N-Acetyl-leukotriene E\(_4\) administered to conscious freely moving rats produced a dose-dependent vasoconstriction in the mesenteric vessels which led to profound reduction of blood flow to the gut. Renal and hindquarter blood flow and vascular resistance were not affected even by high doses of N-acetyl-leukotriene E\(_4\) . N-Acetyl-leukotriene E\(_4\) was 10-fold more potent than the thromboxane analog U-46619 and 1000-fold more potent than prostaglandin F\(_{2a}\) but 2-5-fold less potent than leukotriene D\(_4\)/E\(_4\) to induce mesenteric vasoconstriction. These data indicatc that N-acetylleukotriene E\(_4\) is a biologically active metabolite of peptide leukotrienes, and might play a role in cardiovascular derangements mediated by leukotrienes.},
  subject      = {Neurobiologie},
  language  = {en}
}
@article{SirenLakeFeuerstein1988,
  author    = {Sir{\´e}n, Anna-Leena and Lake, C. R. and Feuerstein, G.},
  title     = {Hemodynamic and neural mechanisms of action of thyrotropin releasing hormone in the rat},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63183},
  year      = {1988},
  abstract  = {Tbe mechanisms mediating the etl'ects ofthyrotropin-releasing hormone (TRH) on the cardiovascular system were studied in the conscious rat. Intracerebroventricolar (i.c. v.) injection of TRH (8 pmol-80 nmollkg) induced dose-dependent lncreases in mean arterial pressure, heart rate, and cardiac index. Rindquarter blood Oow increased due to vasodilation, while an lncrease in renal and mesenteric vascular resistance caused a decrease in blood Oow in the respective organs. The plasma Ievels of norepinephrine a~d epinephrine were increased by TRH, while there was no change in plasma renin activity or vasopressin. Tbe cardiovascular actions of i.c. v. TRH were not in.fluenced by blockade of the renin-angiotensin system or vasopressin receptors. Tbe ganglion blocker chlorisondamine and the a 1- aod al-adrenoreceptor antagooist phentolamlne (2 mg/kg i.v.) abolished the increase in blood pressure and mesenteric vasoconstriction after i.c. v. TRH. Propranolol (2 mg/kg i. v.) blocked the TRH-ioduced increase in cardiac index, heart rate, and hindquarter blood flow. The hindquarter vasodllatlon lnduced by TRH was also blocked by the selective ß1-adrenocept9r antagonist ICI 188,551 (1 or 2 mg/kg i.v.), while tbe ,8,-adrenoceptor blocker practolol (10 mg/kg i.v.) had no eft'ect on the hindquarter vasodiJation produced by TRH but totally blocked the increase in cardiac Index. In adrenal demedullated rats, the systemic hemodynamic eft'ects ofi.c. v. TRH were dimlnished along with the decrease in renal blood flow and lncrease in renal vascular resistance; however, the iocrease in hfndquarter blood flow was attenuated only in adrenal demedullated rats pretreated with the sympathetlc blocker bretylium. The renal vasoconstriction induced by i.c. v. TRH was not abolished by renal denervation. In sinoaortic debufl'ered rats, the pressor, tachycardic, and mesenteric vasoconstrictor responses to centrally administered TRH were significantly potentiated. Taken together, these data soggest that the putative rieurotransmitter TRH may play a role in central regulation of cardiac functions and organ blood flow distribution through both tbe sympathetic nerves and the adrenal medulla. A pivotal roJe for ß1-adrenoceptors in mediation ofhindquarter vasodilation ls also demonstrated.},
  subject      = {Neurobiologie},
  language  = {en}
}
@article{SirenFeuerstein1988,
  author    = {Sir{\´e}n, Anna-Leena and Feuerstein, G.},
  title     = {Cardiovascular effects of rat calcitonin gene-related peptide in the conscious rat},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63236},
  year      = {1988},
  subject      = {Neurobiologie},
  language  = {en}
}
@article{Siren1988,
  author    = {Sir{\´e}n, Anna-Leena},
  title     = {Cardiovascular pharmacology of thyrotropin releasing hormone},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63214},
  year      = {1988},
  subject      = {Neurobiologie},
  language  = {en}
}
@article{SendtnerGnahnWakadeetal.1988,
  author    = {Sendtner, Michael and Gnahn, H. and Wakade, A. and Thoenen, Hans},
  title     = {Is activation of the Na\(^+\)K\(^+\) pump necessary for NGF-mediated neuronal survival?},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42610},
  year      = {1988},
  abstract  = {The ability of nerve growth factor to cause rapid activation of the Na+K+ pump of its responsive cells was examined by measuring the uptake of 86Rb+. A significant increase in 86Rb+ uptake in Ea chick dorsal root ganglion sensory neurons after NGF treatment was seen only if the cells had been damaged during the preparation procedure. Such damaged cells could not survive in culture in the presence of NGF, and undamaged cells that did survive in response to NGF exhibited no increased 86Rb+ uptake rate. Furthermore, cultured calf adrenal medullary cells did not show an increase in 86Rb+ uptake after treatment with NGF, although these cells respond to NGF with an increased synthesis of catecholaminergic enzymes. These results are incompatible with the hypothesis that the mechanism of action of NGF that promotes neuronal survival and enzyme induction results from an initial stimulation of the Na+K+ pump.},
  language  = {en}
}
@inproceedings{SeidelKreuzerSchuessleretal.1988,
  author    = {Seidel, E. and Kreuzer, H. and Sch{\"u}ssler, Ulrich and Okrusch, M. and Lenz, K.-L. and Raschka, H.},
  title     = {K-Ar geochronology of the East-Bavarian basement},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-38874},
  year      = {1988},
  abstract  = {No abstract available},
  language  = {en}
}
@inproceedings{SchuesslerVejnarOkruschetal.1988,
  author    = {Sch{\"u}ssler, Ulrich and Vejnar, Z. and Okrusch, Martin and Rose, D. and Seidel, E.},
  title     = {Geochemistry of metabasites and gabbroic rocks from the Tepla-Domazlice zone.},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39164},
  year      = {1988},
  abstract  = {Various amphibolites, metagabbros and eclogitic relics of the Mariimske Lazne complex, and amphibolites from the Cerna Hora Massif exhibit an uniform geochemical character which compares well with modern mid-ocean ridge basalts. Geochemically these metabasites are similar to the amphibolites of the My to area and to schistose. partly striped amphibolites of the neighbouring Tirschenreuth-Mahring Zone and the Erbendorf-Vohenstrauss Zone (Bavaria). Greenschists and amphibolites from the Domailice metamorphic complex show an alkaline-basaltic tendency conforming to modern within-plate basalts or basalts from anomalous midocean ridge segments. In their chemical character, these metabasites compare well with the flaseramphibolites of the Erbendorf-Vohenstrauss Zone. Fine-grained amphibolites in the Warzenrieth area and gabbroic amphiboltes in the Blatterberg-Hoher Bogen area show normal MORB character. The metamorphosed gabbroic rocks in the southern part of the Neukirchen-Kdyne (meta-) igneous complex are subalkaline-tholeiitic and exhibit a magmatic differentiation trend. They differ from the neighbouring amphibolites by generally lower contents of incompatible elements.},
  language  = {de}
}
@inproceedings{SchuesslerVejnarOkruschetal.1988,
  author    = {Sch{\"u}ssler, Ulrich and Vejnar, Z. and Okrusch, M. and Rose, S. and Seidel, E.},
  title     = {Geochemistry of Metabasites and gabbroic rocks from the Tepla-Domazlice zone},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87511},
  year      = {1988},
  abstract  = {Various amphibolites, metagabbros and eclogitic relics of the Mari{\"a}nske L{\"a}zne complex, and amphibolites from the Cern{\"a} Hora Massif exhibit an uniform geochemical character which compares weil with modern mid-ocean ridge basalts. Geochemically these metabasites are similar to the amphibolites of the Myto area and to schistose, partly striped amphibolites of the neighbouring Tirschenreuth-M{\"a}hring Zone and the Erbendorf-Vohenstrauss Zone (Bavaria). Greenschists and amphibolites from the Domazlice metamorphic complex show an alkaline-basaltic tendency conforming to modern within-plate basalts or basalts from anomalaus midocean ridge segments. In their chemical character, these metabasites compare weil with the flaseramphibolites of the Erbendorf-Vohenstrauss Zone. Fine-grained amphibolites in the Warzenrieth area and (gabbro-) amphibolites in the Bl{\"a}tterberg-Hoher Bogen area show normal MORB character. The metamorphosed gabbroic rocks in the southern part of the Neukirchen-Kdyne (meta-) igneous complex are subalkaline - tholeiitic and exhibit a magmatic differentiation trend. They differ from the neighbouring amphibolites by generally lower contents of incompatible elements.},
  subject      = {Geochemie},
  language  = {en}
}
@inproceedings{SchuesslerOkruschRichteretal.1988,
  author    = {Sch{\"u}ssler, Ulrich and Okrusch, M. and Richter, P. and Seidel, E.},
  title     = {Geochemistry of metabasites and element mobility},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-38880},
  year      = {1988},
  abstract  = {No abstract available},
  language  = {en}
}
@article{Schuessler1988,
  author    = {Sch{\"u}ssler, Ulrich},
  title     = {Mobilisation einzelner Elemente in Amphiboliten aus der Umgebung der KTB-Lokation, Zone Erbendorf-Vohenstrauss, n{\"o}rdliche Oberpfalz},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39248},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Mineralogie},
  language  = {de}
}
@article{SchulzeKuenzler1988,
  author    = {Schulze, Hans Joachim and K{\"u}nzler, Jan},
  title     = {Lebenssituationen alter Menschen in der Stadt : Merkmale und Handlungsbedarf},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-51082},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Soziologie},
  language  = {de}
}
@article{SchomburgLinkLinohetal.1988,
  author    = {Schomburg, D. and Link, M. and Linoh, H. and Tacke, Reinhold},
  title     = {Molek{\"u}lstruktur der Akarizide Chlortrineophylstannan, Chlortris[(dimethylphenylsilyl)methyl]stannan und Trineophyl(1,2,4-triazol-1-yl)stannan-hemihydrat sowie des 2,5-Dimethyl-2,5-diphenylhexans (Bineophyl)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63840},
  year      = {1988},
  abstract  = {Die Kristall- und Molek{\"u}lstrukturen der Akarizide Chlortrineophylstannan (Ia), Chlortris[ ( dimethylphenylsilyl)methyl]stannan (tb) und Trineophyl(1,2,4-triazol-1- yl)stannan-hemihydrat (2a · 0.5H\(_2\)0) wurden durch Einkristall-R{\"o}ntgenstrukturanalysen bestimmt. Zu V ergleichszwecken wurde ausserdem die Struktur des 2,5-Dimethyl-2,5-diphenylhexans (Bineophyl, 4) untersucht. Die Kn{\"u}pfung von drei sehr raumerf{\"u}llenden N eophyl-Resten an ein Zinnatom f{\"u}hrt zu einer deutlichen Verzerrung der tetraedrischen Geometrie [ta: C-Sn-C 117.2°, C-Sn-Cl99.7°; 2a·0.5H20: C-Sn-C 116.9° (Mittelwert), C-Sn-N 100.2° (Mittelwert)]. Austausch der zentralen Kohlenstoffatome in den Neophyt-Substituenten von la durch Siliciumatome f{\"u}hrt zu einer Verringerung des Raumbedarfs und dadurch zu einer erkennbaren Angleichung an die tetraedrische Geometrie [lb: C-Sn-C 113.3° (Mittelwert), C-Sn-Cl 105.3° (Mittelwert)].},
  subject      = {Anorganische Chemie},
  language  = {de}
}
@article{SchneiderSchauliesLiebertBaczkoetal.1988,
  author    = {Schneider-Schaulies, Sibylle and Liebert, UG and Baczko, K. and ter Meulen, V.},
  title     = {Molecular Biological Aspects of Virus-Induced Subacute Encephalomyelitis in Lewis Rats},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-81776},
  year      = {1988},
  abstract  = {no abstract available},
  subject      = {Biologie},
  language  = {en}
}
@article{SchneiderSchauliesLiebertBaczkoetal.1988,
  author    = {Schneider-Schaulies, Sibylle and Liebert, UG and Baczko, K, and ter Meulen, V.},
  title     = {Molecular Biological Analysis of Measles Virus Gene Expression in the CNS of Acutely and Persistently Infected Rat Brain Cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-81784},
  year      = {1988},
  subject      = {Virologie},
  language  = {en}
}
@article{SchneiderSchauliesLiebertBaczkoetal.1988,
  author    = {Schneider-Schaulies, Sibylle and Liebert, U. G. and Baczko, K. and ter Meulen, Volker},
  title     = {Molecular Biological Analyses of Measles Virus Gene Expression in the CNS of Acutely and Persistently Infected Rat Brain Cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-34104},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Masernvirus},
  language  = {en}
}
@phdthesis{SchneiderSchaulies1988,
  author    = {Schneider-Schaulies, Sibylle},
  title     = {Molekularbiologische Charakterisierung der Masernvirusreplikation in zentralen Nervensystem von Lewis- und BN-Ratten},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78465},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {Einleitung: Das Masernvirus (MV) ist ein hochkontagi{\"o}ser, primatenpathogener Erreger, der f{\"u}r die bekannte Masernerkrankung verantwortlich ist...},
  subject      = {Medizin},
  language  = {de}
}
@article{SchneiderSodian1988,
  author    = {Schneider, Wolfgang and Sodian, Beate},
  title     = {Metamemory-memory behavior relationships in young children: Evidence from a memory-for-location task},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62062},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Psychologie},
  language  = {en}
}
@article{SchneiderHasselhorn1988,
  author    = {Schneider, Wolfgang and Hasselhorn, Marcus},
  title     = {Metakognitionen bei der L{\"o}sung mathematischer Probleme: Gestaltungsperspektiven f{\"u}r den Mathematikunterricht},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86477},
  year      = {1988},
  abstract  = {In neueren Untersuchungen zur Mathematikerziehung im Elementarbereich wird verst{\"a}rkt auf die Bedeutung kognitiver Prozesse (Strategien) f{\"u}r die erfolgreiche Bew{\"a}ltigung von Probleml{\"o}seaufgaben hingewiesen. Im vorliegenden Beitrag wird insbesondere auf das Wissen um kognitive Prozesse und deren Steuerung, also auf Metakognitionen eingegangen. Es wird zun{\"a}chst eine Einf{\"u}hrung in traditionelle Kategorien von Metakognition gegeben und dann auf eine Weiterentwicklung eingegangen, die als "Modell des kompetenten Strategie-Anwenders" bekanntgeworden ist. Dieses Modell wird dann als Grundlage f{\"u}r Empfehlungen benutzt, die darauf abzielen, den Mathematikunterricht effizienter zu gestalten.},
  subject      = {Mathematikunterricht},
  language  = {de}
}
@misc{Schneider1988,
  author    = {Schneider, Wolfgang},
  title     = {Book Reviews: Cognition, Metacognition, and Reading},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62079},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Psychologie},
  language  = {en}
}
@article{Schneider1988,
  author    = {Schneider, Wolfgang},
  title     = {Zur Rolle des Wissens bei kognitiven H{\"o}chstleistungen},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87383},
  year      = {1988},
  abstract  = {Neuere Ans{\"a}tze der Hochbegabtenforschung haben demonstriert, daß herausragende intellektuelle F{\"a}higkeiten alleine noch keine kognitiven H{\"o}chstleistungen in sp{\"a}teren Lebensabschnitten garantieren. Insbesondere retrospektive Analysen der Daten genialer bzw. kognitiv hochproduktiver Pers{\"o}nlichkeiten lassen darauf schließen, daß neben Intelligenzmerkmalen auch Wissensaspekte und nichtkognitive Pers{\"o}nlichkeitsmerkmale entscheidend daf{\"u}r verantwortlich sind, daß H{\"o}chstleistungen erzielt werden k{\"o}nnen. Im vorliegenden Beitrag wird ein {\"U}berblick {\"u}ber Studien gegeben, die den Einfluß bereichsspezifiscben Wissens auf kognitive H{\"o}chstleistungen darstellt, daß jedoch ab einem bestimmten Grenzwert intellektueller F{\"a}higkeit allein das Ausmaß bereichsspezifischen Wissens in Kombination mit extremen Auspr{\"a}gungen in nichtkognitiven Merkmalen wie Konzentrationsf{\"a}higkeit, Ausdauer und Erfolgsmotivation dar{\"u}ber entscheidet, ob intellektuelle H{\"o}chstleistungen erbracht werden k{\"o}nnen.},
  subject      = {Hochbegabung},
  language  = {de}
}
@article{SchmuckKobeltLinsenmair1988,
  author    = {Schmuck, R. and Kobelt, F. and Linsenmair, Karl Eduard},
  title     = {Adaptations of the reed frog Hyperbolius viridiflavus (Anura, Hyperbolidae) to its arid environment: V. Iridophores and nitrogen metabolism},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78094},
  year      = {1988},
  abstract  = {Ofall amphibians living in arid habitats, reed frogs (belonging to the super species Hyperolius viridiflavus) are the most peculiar. Froglets are able to tolerate dry periods of up to 35 days or longer immediately after metamorphosis, in climatically exposed positions. They face similar problems to estivating juveniles, i.e. enduranee of long periods of high temperature and low RH with rather limited energy and water reserves. In addition, they must have had to develop meehanisms to prevent poisoning by nitrogenous wastes that rapidly accumulate during dry periods as a metabolie consequenee of maintaining a non-torpid state. During dry periods, plasma osmolarity of H. v. taeniatus froglets strongly increased, mainly through urea accumulation. Urea accumulation was also observed during metamorphic climax. During postmetamorphic growth, chromatophores develop with the density and morphology typical of the adult pigmentary pattern. The dermal iridophore layer, which is still incomplete at this time, is fully developed within 4-8 days after metamorphosis, irrespective of maintenance conditions. These iridophores mainly contain the purines guanine and hypoxanthine. The ability of these purines to reflect light provides an excellent basis for the role of iridophores in temperature regulation. In individuals experiencing dehydration stress, the initial rate of purine synthesis is doubled in eomparison to specimens continuously maintained under wet season conditions. This increase in synthesis rate leads to a rapid increase in the thiekness of the iridophore layer, thereby effectively reducing radiation absorption. Thus, the danger of overheating is diminished during periods of water shortage when evaporative cooling must be avoided. After the development of an iridophore layer of sufficient thickness for effective radiation reflectance, synthesis of iridophore pigments does not cease. Rather, this pathway is further used during the remaining dry season for solving osmotic problems eaused by accumulation of nitrogenous wastes. During prolonged water deprivation, in spite of reduced metabolic rates, purine pigments are produced at the same rate as in wet season conditions. This leads to a higher relative proportion of nitrogen end products being stored in skin pigments under dry season conditions. At the end of an experimental dry season lasting 35 days, up to 38\% of the accrued nitrogen is stored in the form of osmotically inactive purines in thc skin. Thus the osmotic problems caused by evaporative water loss and urea production are greatly reduced.},
  subject      = {Biologie},
  language  = {en}
}
@article{SchenkKuemmerleBurschka1988,
  author    = {Schenk, Wolfdieter A. and Kuemmerle, Dagmar and Burschka, Christian},
  title     = {Die Koordinationschemie C=S-funktioneller Verbindungen: VIII. Addition aktivierter Alkine an Wolfram-CS\(_2\)-Komplexe und Aufbau tetraedrischer Methylidindicobaltwolfram-Cluster},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-46676},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Chemie},
  language  = {de}
}
@article{ScheerDabauvalleMerkertetal.1988,
  author    = {Scheer, Ulrich and Dabauvalle, Marie-Christine and Merkert, Hilde and Benavente, Ricardo},
  title     = {The nuclear envelope and the organization of the pore complexes},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-34275},
  year      = {1988},
  abstract  = {No abstract available},
  language  = {en}
}
@article{SchartlPeter1988,
  author    = {Schartl, Manfred and Peter, R. U.},
  title     = {Progressive growth of fish tumors after transplantation into thymus-aplastic (nu/nu) mice},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61833},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@inproceedings{SchartlMaeuelerRaulfetal.1988,
  author    = {Schartl, Manfred and M{\"a}ueler, Winfried and Raulf, Friedrich and Robertson, Scott M.},
  title     = {Molecular aspects of melanoma formation in Xiphophorus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72689},
  year      = {1988},
  abstract  = {No abstract available.},
  subject      = {Schwertk{\"a}rpfling},
  language  = {en}
}
@article{Schartl1988,
  author    = {Schartl, Manfred},
  title     = {A sex chromosomal restriction-fragment-length marker linked to melanoma-determining Tu loci in Xiphophorus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61842},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@article{SargeCammengaBeckeretal.1988,
  author    = {Sarge, S. and Cammenga, H. K. and Becker, B. and Rohr-Aehle, R. and Tacke, Reinhold},
  title     = {Energetic and kinetic investigation of thermally induced molecular rearrangements of esters of (hydroxymethyl)hydridosilanes by DSC},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63850},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{SagelsdorffLutzSchlatter1988,
  author    = {Sagelsdorff, P. and Lutz, Werner K. and Schlatter, C.},
  title     = {DNA methylation in rat liver by daminozide, 1,1-dimethylhydrazine, and dimethylnitrosamine},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60875},
  year      = {1988},
  abstract  = {DNA Methylation in Rat Li ver by Daminozide, 1, 1-Dimethylhydrazine, and Dimethylnitrosamine. SAGELSDORFF, P., LUTZ, W. K., AND ScHLAITER C. (1988). Fundam. Appl. Toxico/. 11, 723-730. [methyP4C]Daminozide (succinic acid 2',2'-dimethylhydrazide; 37 mgjkg), l,l( 14C]dimethylhydrazine (UDMH; 19 mgtkg), and (14C]dimethylnitrosamine (DMNA; 0.1 mg/ kg) were administered by oral gavage to male Sprague-Dawley rats. After 24 hr, the animals were killed and DNA was purified from the livers to constant specific radioactivity. After enzymatic degradation of the DNA to the 3'-deoxynucleotides the Ievel of DNA methylation was determined by HPLC analysis. Radiolabeled 7-methylguanine (7mG) was identified by cochromatography with unlabeled 7mG added as standard after acidic depurination of DNA and HPLC analysis ofpurines and apurinic acid. All three compounds were found to methylate DNA. The relative potencies were 1:47:4900 for daminozide:UDMH:DMNA. With [methyPH]UDMH, the formation of7mG was investigated as a function of dose administered, at 20, 2, and 0.2 mgj kg. The methylation ofDNA was strictly proportional to the dose. The data were used to compare the Ievel of DNA alkylation derived from residues of daminozide and UDMH in treated apple with the genotoxicity of the intake of N-nitroso compounds in Germany and Japan. It is estimated that these residues could Iead to a DNA methylation in the Ii ver of about 6\% of an average exposure to DMNA},
  subject      = {Toxikologie},
  language  = {en}
}
@incollection{Ruhe1988,
  author    = {Ruhe, Ernstpeter},
  title     = {Comment dater la naissance du roman par lettres en France?},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-34147},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {No abstract available},
  language  = {en}
}
@article{Ruhe1988,
  author    = {Ruhe, Ernstpeter},
  title     = {Normativit{\"a}t versus libertas. Die Entwicklung der franz{\"o}sischen Briefrhetorik im 16. Jahrhundert},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-32447},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Brief ; Literatursemiotik ; Kongress ; Freiburg <{\"U}echtland},
  language  = {de}
}
@article{RubtsovOganessyanGorboulevetal.1988,
  author    = {Rubtsov, P. M. and Oganessyan, R. G. and Gorboulev, Valentin G. and Skryabin, K. G. and Bayev, A. A.},
  title     = {Genetic engineering of peptide hormones : II. Possible polymorphism of preprolactin in cattle. Data of molecular cloning},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-46975},
  year      = {1988},
  abstract  = {Primary structure is determined of an insertion of a clone isolated from the library of hypophyseal cDNA of cattle by hybridization with a probe specific for prolactin. Analysis of nucleotide sequences showed that in the process of cloning, reorganization occurred in structure of preprolactin cDNA, including an inversion of the 5'-terminal and deletion of the central section of cDNA. Nevertheless, from structure of cDNA, nucleotide sequences can be deduced of extended 5'- and 3'-terminal sections of preprolactin mRNA in cattle with lengths of 257 and 551 nucleotide residues, respectively. When these sequences are compared to those established previously, some differences were found in primary structure. The most important of them is the presence of an additional codon which codes alanine at the position (-22) of the signal peptide. It is suggested that heterogeneity of preprolactin mRNA of cattle in the section coding the signal peptide is the result of alternative splicing, as was shown for preprolactin mRNA in rats.},
  language  = {en}
}
@article{RoseSzopaHanetal.1988,
  author    = {Rose, Kathleen M. and Szopa, Jan and Han, Fu-Sheng and Cheng, Yung-Chi and Richter, Arndt and Scheer, Ulrich},
  title     = {Association of DNA topoisomerase I and RNA polymerase I: A possible role for topoisomerase I in ribosomal gene transcription},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33901},
  year      = {1988},
  abstract  = {RNA polymerase I preparations purified from a rat hepatoma contained DNA topoisomerase activity. The DNA topoisomerase associated with the polymerase had an Mr of 110000, required Mg2+ but not ATP, and was recognized by anti-topoisomerase I antibodies. When added to RNA polymerase I preparations containing topoisomerase activity, anti-topoisomerase I antibodies were able to inhibit the DNA relaxing activity of the preparation as well as RNA synthesis in vitro. RNA polymerase II prepared by analogous procedures did not contain topoisomerase activity and was not recognized by the antibodies. The topoisomerase I: polymerase I complex was reversibly dissociated by column chromatography on Sephacryl S200 in the presence of 0.25 M (NH4hS04. Topoisomerase I was immunolocalized in the transcriptionally active ribosomal gene complex containing RNA polymerase I in situ. These data indicate that topoisomerase I and RNA polymerase I are tightly complexed both in vivo and in vitro, and suggest a role for DNA topoisomerase I in the transcription of ribosomal genes.},
  language  = {en}
}
@article{ReimerRaskaScheeretal.1988,
  author    = {Reimer, Georg and Raska, Ivan and Scheer, Ulrich and Tan, Eng M.},
  title     = {Immunolocalization of 7-2-ribonucleoprotein in the granular component of the nucleolus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33890},
  year      = {1988},
  abstract  = {Certain autoimmune sera contain antibodies against a nucleolar ribonucleoprotein particle associated with 7-2-RNA (R. Reddy et al. (1983) J. Bioi. Chem . 258, 1383; C. Hashimoto and J. A. Steitz (1983) J. Bioi. Chem. 258, 1379). In this study, we showed by immunofluorescence microscopy that antibodies reactive with 7-2-ribonucleoprotein immunolocalized in the granular regions of actinomycin D and 5,6-dichloro-I-j3-D-ribofuranosylbenzimidazole (DRB)-segregated nucleoli from Vero cells. By electron microscopic immunocytochemistry, antigen-antibody complexes were located in the granular component of transcriptionally active nucleoli from rat liver hepatocytes and HeLa cells. Anti-7- 2-RNP antibodies from two autoimmune sera immunoprecipitated a major protein of Mr 40,000 from e5S] methionine-Iabeled HeLa cell extract. The immunolocalization data suggest that 7-2-ribonucleoprotein may be involved in stages of ribosome biogenesis which take place in the granular component of the nucleolus, i.e., assembly, maturation, and/or transport of preribosomes},
  language  = {en}
}
@article{PletichaGeuder1988,
  author    = {Pleticha-Geuder, Eva},
  title     = {Ex Bibliotheca Monasterii Neustatt ad Moenum. Zur Geschichte der Bibliothek von Kloster Neustadt am Main bis zur S{\"a}kularisation.},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-35469},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {W{\"u}rzburg / Universit{\"a}tsbibliothek},
  language  = {de}
}
@article{PawelzikHeesemannHackeretal.1988,
  author    = {Pawelzik, M. and Heesemann, J. and Hacker, J{\"o}rg and Opferkuch, W.},
  title     = {Cloning and characterization of a new type of fimbria (S/F1C-related fimbria) expressed by an Escherichia coli O75:K1:H7 blood culture isolate},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59529},
  year      = {1988},
  abstract  = {The Escherichia coli blood culture isolate BK658 (07S:K1:H7) expresses F1A and F1B fimbriae as weil as a third fimbrial type which reacts with anti-S-fimbrial antiserum but fails to show S-specific binding properlies (i.e., agglutination of bovine erythrocytes). To characterize these fimbriae, we cloned the respective genetic determinant in E. coli K-12. The resulting recombinant clone HB101(pMMP658-6) expresses fimbriae of 1.2-p.m length and a diameter of approximately 7 nm. The determinant codes for the fimbrillin subunit, a protein of 17 kUodaltons in size, and for at least five other proteins of 87, 31, 23, 14.3, and 13.8 kUodaltons. By restriction analysis and by DNA-DNA hybridization, it could be shown that the cloned fimbrial determinant of strain BK658 exhibits a high degree of sequence homology to the gene clusters coding for S fimbrial adhesins (sfa) and F1C fimbriae (/oc). By using the Western blot (immunoblot) technique and a quantitative enzyme-linked immunosorbent assay, it could be further demonstrated that the cloned fimbriae of BK658, S fimbriae, and FlC fimbriae share cross-reactive epitopes as weil as antigenic determinants specific for each fimbrial type. No antigenic cross-reactivity with F1C fimbriae could be detected. The results indicate a genetical and serological relatedness of the cloned fimbriae toS fimbriae and F1C fimbriae. Therefore, this new type of fimbriae is preliminarily termed SIF1C-related fimbriae (Sfr).},
  subject      = {Infektionsbiologie},
  language  = {en}
}
@article{ParkkinenKorhonenPereetal.1988,
  author    = {Parkkinen, J. and Korhonen, T. K. and Pere, A. and Hacker, J{\"o}rg and Soinila, S.},
  title     = {Binding sites in the rat brain for Escherichia coli S fimbriae associated with neontal meningitis},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59500},
  year      = {1988},
  abstract  = {Escherichia coli strains that cause sepsis and meningitis in neonatal infants carry S fimbriae that bind to sialyl galactoside units of cell surface glycoproteins. To investigate the possible role of S fimbriae in determining the tissue tropism of neonatal menlngitis, we have studied the preselice of binding sites for S fimbriae in different tissues of the neonatal rat which is susceptible to meningitis caused by S-fimbriated E. coli. Purified S fimbriae were incubated on cryostat sections of different rat oipns and their bindina was assessed by indirect immunofluorescence. In the bnin of the neonatal rat, S fimbriae specifically bound to the luminal surfaces of the vascular endothelium and of the epithelium lining the choroid plexuses and bnin ventricles. The · bindlog W.s completely inhibited by the trisaccharide NeuAca2-3Ga)ßl-4Gic, a receptor analogue of S fimbriae, and by a preceding neuraminidase treatment of the sections. A recombinant E. coli strain expressina S fimbriae adhered in large numbers to the same tissue sites in the neonatal brain sections as did the purified fimbriae, · whereas the nonfimbriated host strahi and a recombiiuuit strain expresslog P fi.mbriae did not adhere to brain tissues. The results soggest that adhesion of S-fimbriated bacteria to the binding sites observed in the neonatai bnin has a pathogenetic roJe durlog bacterial Invasion from cii'culation into the cerebrospinal fluid.},
  subject      = {Infektionsbiologie},
  language  = {en}
}
@article{OttHoschuetzkyJannetal.1988,
  author    = {Ott, M. and Hosch{\"u}tzky, H. and Jann, K. and Van Die, I. and Hacker, J{\"o}rg},
  title     = {Gene clusters for S fimbrial adhesin (sfa) and F1C Fimbriae (foc) of Escherichia coli: Comparative aspects of structure and function},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59519},
  year      = {1988},
  abstract  = {Fimbrial 8dhesins en8ble b8cteria to 8ttach t9 eucaryotic ceU~. The genetic determin8nts for S fimbrial 8dhesins (sja) an.d for FlC ("pseudotype I") fimbri8e ifoc) were compared. Sfa and FlC represent functionally distinct 8dbesins in tbeir receptor specificities. Nevertheless, 8 high degree of bomology between both determin8nts was found on the basis of DNA-DNA hybridizations. Characteristic difl'erences in the restriCtion maps of tbe corresponding gene clusters, bowever, were visible in regions coding for the fimbrial subunits and for the S-specific 8dhesin. While a plasmid carrying the geneiic deternlinant for FlC fimbri8e was 8ble to complement transposon-induced sfa mutants, 8 plasmid carrying tbe genetic determin8nt for 8 tbird 8dht\$in type, termed P fimbriae, was un8ble to do so. Proximal sfa-specific sequences carrying the S fimbrial st'"uctural gene were fused to sequences representing tbe di\$tal part of the foc gene cluster to form 8 hybrid cluster, and tbe foc proxim~ region coding for tbe structural protein was Iigated to sfa distal sequences to form 8 second hybrid. Botb hybrid clones produced intact fimbriae. Anti-FlC monoclonal8ntibodies (MAbs) only recognized clones which produced FlC fimbriae, and an ~ti-S 8dhesin MAb marked clones whicb expressed the S adhesin. Bowever, one of four other anti-S fimbri8e-specific MAbs reacted witb both fimbrial structures, S and FlC, indicating 8 common epitope on both antigens. The results presented bere ~upport tbe view th8t sfa and foc determinants code for fimbri8e tb8t 8re simil8r in several aspects, wbile the P fimbri8e are members of 8 more distantly rel8ted group.},
  subject      = {Infektionsbiologie},
  language  = {en}
}
@article{MaeuelerRaulfSchartl1988,
  author    = {M{\"a}ueler, Winfried and Raulf, Friedrich and Schartl, Manfred},
  title     = {Expression of proto-oncogenes in embryonic, adult, and transformed tissue of Xiphophorus (Teleostei: Poeciliidae)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86233},
  year      = {1988},
  abstract  = {In Xiphophorus the causative, primary cellular oncogene for melanoma formation has been assigned by classical genetics to a sex-chromosomal locus, designated Tu. Activation of Tu was proposed to be the result of the elimination of Tu-specific regulatory genes which normally suppress the transforming function in the nontumorous state. In order to understand the role which known proto-oncogenes migbt play in this process, we have analysed the expression of src, erb A, erb B, ras, abl, sis and mil related genes from Xiphophorus during embryogenesis, in non-tumorous organs and in melanoma cells. For src, ras, erb B and sis a differential expression during embryogenesis and/or in normal organs was detected, with preferential expression of src in neural tissues, a high abundance of sis transcripts in an embryonal epitheloid cellline and of erbB transcripts in the head nephros. In melanoma cells ras, src and a v-erb B related gene were found to be expressed. The src gene most likely is more involved in secondary processes during tumor progression, while the expression of the v-erb B related gene might be transformation-specific because recently such a sequence was found to map to the close vicinity of the Tu-locus.},
  subject      = {Schwertk{\"a}rpfling},
  language  = {en}
}
@article{MunoaHackerJuarez1988,
  author    = {Munoa, F. and Hacker, J{\"o}rg and Juarez, A.},
  title     = {Characterization of a chromosomal mutant that blocks hemolysin excretion in Escherichia coli},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59534},
  year      = {1988},
  abstract  = {We analyzed an Escherichia coli strain which harbours a chromosomal mutation that blocks the hemolysin excretion. Compartmentation studies showed that hemolysin accumulates in the cytoplasm and not in the periplasm. The mutation did not affect the SDS-PAGE protein pattern of the outer membrane, although some alterations were apparent in the periplasmic protein pattern. The mutant strain, E. coli Hsb-1 also failed to export a cloned fimbrial adhesin. The mutation maps in the min. 3.5 of the E. coli genetic map.},
  subject      = {Infektionsbiologie},
  language  = {en}
}
@article{MollScollayMitchell1988,
  author    = {Moll, Heidrun and Scollay, R. and Mitchell, G. F.},
  title     = {Resistance to cutaneous leishmaniasis in nude mice injected with L3T4+ T cells but not with Ly-2+ T cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61269},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Biologie},
  language  = {en}
}
@article{MollMitchell1988,
  author    = {Moll, Heidrun and Mitchell, Graham F.},
  title     = {Analysis of variables associated with the promotion of resistance, and its abrogation, in T cell-reconstituted nude mice infected with Leishmania major},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-30949},
  year      = {1988},
  abstract  = {No abstract available},
  language  = {en}
}
@article{MollBoesingSchneider1988,
  author    = {Moll, Heidrun and B{\"o}sing-Schneider, Rita},
  title     = {The transplantation barrier of nude mice},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-46045},
  year      = {1988},
  abstract  = {Syngeneic memory cells can be stimulated to yield a secondary immune response after their transfer into irradiated euthymie recipients as well as into young thymusless nude mice. It is shown that nude mice older than twelve weeks of age are not permissive towards memory cell activation as it is found in non-irradiated euthymie animals. This barrier to isogeneie or congeneic cells seems to be caused by a pool of cyclophosphamide-sensitive cells. Since young nude mice could be rendered as unpermissive as older nude mice by pretreatment with either PNA-agglutinable thymus cells or nylon-wool passed spleen cells, it is suggested that an increased number of precursor T cells in older nude mice might induce this effect. Further experiments with monoclonal antibodies against the Lyt-l, Lyt-2, and L3T4 marker on T cells indicate that T -helper/inducer activity might be required to establish the "isogeneie barrief" in nude mice.},
  language  = {de}
}
@inproceedings{MaurerBannertRethwilmetal.1988,
  author    = {Maurer, B. and Bannert, H. and Rethwilm, Axel and Darai, B. and Fl{\"u}gel, R. M.},
  title     = {Characterization of the env gene and of two novel coding regions of the human spumaretrovirus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86334},
  year      = {1988},
  abstract  = {Recombinant clones harboring retroviral DNA were established. The nucleotide sequence of the central and 3' region of the genome of the human spumaretrovirus was determined. The 5' end of the deduced protein sequence was homologaus to the endonuclease domain of retroviral reverse transcriptases. A small intergenic region is followed by a lang open reading frame of 985 aminoacid residues that according to its genomic location and structural features is a typical retroviral env gene. Surprisingly, the postenv region contains two open reading frames that encodes two novel retroviral genes, termed bel-l and bel-2. The 3' LTR is 963 nucleotides lang and contains the signal sequences characteristic for transcriptional regulation of retrovirus genomes.},
  subject      = {Spumaviren},
  language  = {en}
}
@article{MauelerBarnekowEigenbrodtetal.1988,
  author    = {Maueler, W. and Barnekow, A. and Eigenbrodt, E. and Raulf, F. and Falk, H. F. and Telling, A. and Schartl, Manfred},
  title     = {Different regulation of oncogene expression in tumor and embryonal cells of Xiphophorus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86240},
  year      = {1988},
  abstract  = {Melanoma formation in the poeciliid fish Xiphophorus is mediated primarily by a cellular oncogene, designated Tu. Elimination of Tu-specific genes releases the transforming function of Tu and leads to melanoma formation. Southern blot analyses revealed a tight linkage of a v-erb B related gene to the Tu-locus and Northern blot analyses of RNA of solid melanomas indicated a coordinated deregulation and for mutational activation of several oncogenes. In order to get a better insight into the regulation of oncogene expression in normal and transformed cells of Xiphophorus, we studied the expression of Xsrc, Xras, Xmyc, Xerb A, Xsis, and the v-erb B related gene in a melanoma derived cell line (PSM) and an embryonic cell line (A2) under conditions of low growth factor supply. Both celllines express the Xsrc, Xmyc, and Xras genes, while PSM cells in addition express the v-erb B related gene and A2 cells the Xsis gene. In PSM cells serum deprivation leads to an accumulation of most of the oncogene mRNAs analysed. This is most apparent for a 5.0 kb transcript of the v-erb B related gene, probably due to an increase in transcript stability. The levels of these mRNAs returned to normal within 2h after stimulation with 10\% fetal calf serum. At the protein level we observed an initial decrease followed by an increase of the n-p60c-src kinase (the protein product of tbe Xsrc gene) activity in cells deprived of serum. Serum stimulation restored a normal pp60"-src kinase activity. In contrast serum deprivation of A2 cells reduced the transcript amounts of each of the oncogenes analysed. The same holds true for one beta-tubulin transcript, while the level of a second beta-tubulin transcript was unaffected. Serum stimulation led to a reactivation of Xras and Xsrc after a delay of approximately 48b. The pp60(c-src) kinase activity was found to be 6-10 times lower as compared to the PSM cells and did not differ between serum deprived and serum stimulated cells. Enzyme activities and isoenzyme patterns of several glycolytic enzymes were found to be not affected by serum deprivation and stimulation in both celllines.},
  subject      = {Schwertk{\"a}rpfling},
  language  = {en}
}
@article{LutzMaier1988,
  author    = {Lutz, Werner K. and Maier, P.},
  title     = {Genotoxic and epigenetic chemical carcinogenesis: one process, different mechanisms},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60884},
  year      = {1988},
  abstract  = {Chemieals that induce cancer in an intact organism are called carcinogens. This term does not differentiale between their various modes of action. In this review, Werner Lutz and Peter Maier make a mechanistic distinction between carcinogens that alter the genetic information and carcinogens that interfere with epigenetic processes. They considercardnogenesis tobe an ongoing, part1y unavoidable process which is based on a succession of mutations, most likely in stem cells, leading to autonomaus cellular growth regulation. Chemical carcinogens either induce such changes through mutations (genotoxic carcinogens) or they aceeierate the accumulation of critica1 spontaneaus mut11tions (epigenetic carcinogens). Examples are given for both classes of carcinogens, and for the processes that act at genoto:tic/nuclear 11nd epigenetic/mitotic Ievels.},
  subject      = {Toxikologie},
  language  = {en}
}
@article{LutzDeuberCaviezeletal.1988,
  author    = {Lutz, Werner K. and Deuber, R. and Caviezel, M. and Sagelsdorff, P. and Friederich, U. and Schlatter, C.},
  title     = {Trenbolone growth promotant: covalent DNA binding in rat liver and in Salmonella typhimurium, and mutagenicity in the Ames test},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60897},
  year      = {1988},
  abstract  = {DNA binding in vivo: (6,7-\(^3\)H]ß-trenbolone (ß-TBOH) was administered p.o. and i.p. to rats. After 8 or 16 h, DNA was isolated from the livers and purified to constant specific radioactivity. Enzymatic digestion to deoxyribonucleotides and separation by HPLC revealed about 90\% ofthe DNA radioactivity eluting in the form of possible TBOH-nucleotide adducts. The extent of this genotoxicity, expressed in units of the Covalent Binding Index, CBI = (~mol TBOH bound per mol nucleotide)/(mmol TBOH administered per kg body weight) spanned from 8 t~ 17, i. e. was in the range found with weak genotoxic carcmogens. Ames test: low doses of ß-TBOH increased the number of revertants in Salmonella strain TAl 00 reproducibly and m a dose-dependent manner. The mutagenic potency was 0.2 revertants per nmol after preincubation of the bacteria (20 min at 37° C) with doses between 30 and 60 \(\mu\)g per plate (47 and 94 \(\mu\)g/ml preincubation mixture). Above this dose, the number of revertants decreased to control values, accompanied by a reduction in survival. The addition of rat liver S9 inhibited the mutagenicity. DNA binding in vitro: calf thymus DNA was incubated with tritiated ß-TBOH with and without rat liver S9 Highest DNA radioactivities were determined in the absence of the "activation" system. Addition of inactive S9 (without cofactors) reduced the DNA binding by a factor of up to 20. Intermediate results were found with active S9. DNA binding in Salmonella: ß-TBOH was irreversibly bound to DNA isolated from S. typhimurium TA100 after incubation of bacteria with [\(^3\)H]ß-TBOH. Conclusions: Covalent DNA binding appears to be the mechanism of an activation-independent ("direct") mutagenicity of TBOH which is not easily detected because of the bactericidal activity. The genotoxicity risk arising from exposure of humans to trenbolone residues in meat was estimated using the in vivo data and compared to that from the exposure to unavoidable genotoxins aflatoxin B1 and dimethylnitrosamine. It ts concluded that trenbolone residues represent only a low genotoxic risk.},
  subject      = {Toxikologie},
  language  = {en}
}
@article{LohseKlotzSalzeretal.1988,
  author    = {Lohse, Martin J. and Klotz, Karl-Norbert and Salzer, Manfred J. and Schwabe, Ulrich},
  title     = {Adenosine regulates the \(Ca^{2+} \) sensitivity of mast cell mediator release : (histamine secretion/inositol phosphates/calcium)},
  series = {Proceedings of the National Academy of Sciences of the United States of America},
  volume    = {85},
  journal   = {Proceedings of the National Academy of Sciences of the United States of America},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-127883},
  pages     = {8875-8879},
  year      = {1988},
  abstract  = {Mast cells release histamine and other mediators of allergy in response to stimulation of their IgE receptors. This release is generally thought to be mediated by an elevation of cytosolic \(Ca^{2+}\). Recent evidence suggests that there might be factors that modulate the coupling between \(Ca^{2+}\) levels and mediator release. The present report identifies adenosine as one such modulator. Adenosine and several of its metabolically stable analogues were shown to enhance histamine release from rat peritoneal mast cells in response to stimuli such as concanavalin A. Metabolizing endogenous adenosine with adenosine deaminase dampened the response to stimuli, whereas trapping endogenous adenosine inside mast cells with nucleoside-transport inhibitors markedly enhanced stimulated histamine release. The metabolically stable adenosine analogue 5' -(N-ethylcarboxamido)adenosine (NECA) did not affect the initial steps in the sequence from IgE-receptor activation to mediator release, which are generation of inositol trisphosphate and increase of cytosolic \(Ca^{2+}\). However, NECA did enhance the release induced in ATP-permeabilized cells by exogenous \(Ca^{2+}\), but it had no effect on the release induced by phorbol esters. These data suggest that adenosine sensitizes mediator release by a mechanism regulating stimulus-secretion coupling at a step distal to receptor activation and second-messenger generation.},
  language  = {en}
}
@article{LohseKlotzSchwabeetal.1988,
  author    = {Lohse, M. J. and Klotz, Karl-Norbert and Schwabe, U. and Cristalli, G. and Vittori, S. and Grifantini, M.},
  title     = {2-Chloro-N\(^6\)-cyclopentyladenosine: a highly selective agonist at A\(_1\) adenosine receptors},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60279},
  year      = {1988},
  abstract  = {2-Chloro-N\(^6\)-cyclopentyladenosine (CCPA) was synthesized as a potential high affinity ligand for At adenosine receptors. Binding of [\(^3\)H]PIA to A1 receptors of rat brain membranes was inhibited by CCP A with a Ki-value of 0.4 nM, compared to a Ki-value of 0.8 nM for the parent compound N\(^6\)-cyclopentyladenosine (CPA). Binding of [\(^3\)H]NECA to A\(_2\) receptors of rat striatal membranes was inhibited with a Ki-value of 3900 nM, demonstrating an almost 10,000-fold A\(_1\)-selectivity of CCPA. CCP A inhibited the activity of rat fat cell membrane adenylate cyclase, a model for the A\(_1\) receptor, with an IC\(_{50}\)-value of 33 nM, and it stimulated the adenylate cyclase activity of human platelet membranes with an EC\(_{50}\)-value of 3500 nM. The more than 100-fold A\(_1\)-selectivity compares favourably with a 38-fold selectivity of CPA. Thus, CCPA is an agonist at A\(_1\) adenosine receptors with a 4-fold higher selectivity and 2-fold higher affinity than CPA, and a considerably higher selectivity than the standard At receptor agonist R-N\(^6\) -phenylisopropyladenosine (R-PIA). CCP A represents the agonist with the highest selectivity for A\(_1\) receptors reported so far.},
  subject      = {Toxikologie},
  language  = {en}
}
@article{LohseKlotzDiekmannetal.1988,
  author    = {Lohse, M. J. and Klotz, Karl-Norbert and Diekmann, E. and Friedrich, K. and Schwabe, U.},
  title     = {2',3'-Dideoxy-N\(^6\)-cyclohexyladenosine: an adenosine derivative with antagonist properties at adenosine receptors},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60282},
  year      = {1988},
  abstract  = {Tbe 2',3'-dideoxy analogue of the potent A\(_1\) receptor agonist, N\(^6\)-cyclohexyladenosine (CHA), was synthesized as a potential antagonist for the A\(_1\) adenosine receptor. In sturlies on adenylate cyclase 2',3'-dideoxy-N\(^6\)-cyclohexyladenosine (ddCHA) did not show agonist properties at A\(_1\) or at A\(_2\) receptors. However, it antagonized the inhibition by R-PIA of adenylate cyclase activity of fat cell membranes via A\(_1\) receptors with a K\(_i\) value of 13 \(\mu\)M. ddCHA competed for the binding of the selective A1 receptor antagonist, [\(^3\) HJ8-cyclopentyl-1,3-dipropylxantbine ([\(^3\)H]DPCPX), to rat brain membranes with a K\(_i\) value of 4.8 \(\mu\)M; GTP did not affect the competition curve. In contrast to the marked stereoselectivity of the A\(_1\) receptor for the cx- and the natural ß-anomer of adenosine, the cx-anomer of ddCHA showed a comparable affinity for the A\(_1\) receptor (K\(_i\) value 13.9 \8\mu\)M). These data indicate that the 2'- and 3'-hydroxy groups of adenosine and its derivatives are required foragonist activity at and high affinity binding to A\(_1\) adenosine receptors and for the distinction between the cx- and ß-forms.},
  subject      = {Toxikologie},
  language  = {en}
}
@incollection{LohseKlotzSchwabeetal.1988,
  author    = {Lohse, M. J. and Klotz, K.-N. and Schwabe, U. and Christalli, G. and Vittori, S. and Grifantini, M.},
  title     = {Pharmacology and Biochemistry of Adenosine Receptors},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86251},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {Adenosine modulates a variety of physiological functions via membrane-bound receptors. These receptors couple via G proteins to adenylate cyclase and K+channels. The A1 subtype mediates an inhibition of adenylate cyclase and an opening of K+-channels, and the A2 subtype a Stimulation of adenylate cyclase. Both subtypes have been characterized by radioligand binding. This has facilitated the development of agonists and antagonists with more than 1000-fold A1 selectivity. A1-selective photoaffinity labels have been used for the biochemical characterization of A1 receptors and the study of their coupling to adenylate cyclase. Such selective ligands allow the analysis of the involvement of adenosine receptors in physiological functions. Selective interference with adenosine receptors provides new pharmacological tools and eventually new therapeutic approaches to a number of pathophysiological states.},
  subject      = {Adenosinrezeptor},
  language  = {en}
}
@article{LohseElgerLindenbornFotinosetal.1988,
  author    = {Lohse, M. J. and Elger, B. and Lindenborn-Fotinos, J. and Klotz, Karl-Norbert and Schwabe, U.},
  title     = {Separation of solubilized A\(_2\) adenosine receptors of human platelets from non-receptor [\(^3\)H]NECA binding sites by gel filtration},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60309},
  year      = {1988},
  abstract  = {Human platelet membranes were solubilized with the zwitterionic detergent CHAPS (3-[3-(cholamidopropyl)dimethylammonio]- 1-propanesulfonate) and the solubilized extract subjected to gel ftltration. Binding of the adenosine receptor agonist [\(^3\)H]NECA (5'-N-ethylcarboxamidoadenosine) was measured to the eluted fractions. Two [\(^3\)H]NECA binding peaks were eluted, the first of them with the void volume. This first peak represented between 10\% and 25\% of the [\(^3\)H]NECA binding activity eluted from the column. It bound [\(^3\)H]NECA in a reversible, saturable and GTPdependent manner with an affinity of 46 nmol/1 and a binding capacity of 510 fmol/mg protein. Various adenosine receptor ligands competed for the binding of [\(^3\)H]NECA to the frrst peak with a pharmacological proftle characteristic for the A\(_2\) adenosine receptor as determined from adenylate cyclase experiments. In contrast, most adenosine receptor ligands did not compete for [\(^3\)H]NECA binding to the second, major peak. These results suggest that a solubilized A\(_2\) receptor-Gs protein complex of human platelets can be separated from other [\(^3\)H]NECA binding sites by gel filtration. This allows reliable radioligand binding studies of the A2 adenosine receptor of human plate1ets.},
  subject      = {Toxikologie},
  language  = {en}
}
@incollection{LinsenmairTyrellSchulzeetal.1988,
  author    = {Linsenmair, Karl Eduard and Tyrell, Hartmann and Schulze, Hans-Joachim and M{\"u}ller, Klaus E.},
  title     = {Familie und Kleingruppen},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44451},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Psychobiologie},
  language  = {de}
}
@article{LinsenmairSchmuck1988,
  author    = {Linsenmair, Karl Eduard and Schmuck, R.},
  title     = {Adaptations of the reed frog Hyperbolius viridiflavus to its arid environment. III. Aspects of nitrogen metabolism and osmuregulation in the reed frog, H. viridiflavus taeniatus, with special reference to the role of iridophores},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78108},
  year      = {1988},
  abstract  = {Reed frogs of the superspecies Hyperolius viridiflavus occur throughout the seasonally very dry and hot African savannas. Despite their small size (300-700 mg), estivating reed frogs do not avoid stressful conditions above ground by burrowing into the soil, but endure the inhospitable climate relatively unprotected, clinging to mostly dry grass sterns. They must have emcient mechanisms to enable them to survive e.g. very high temperatures, low relative hurnidities, and high solar radiation loads. Mechanisms must also have developed to prevent poisoning by the nitrogenous wastes that inevitably result from protein and nucleotide turnover. In contrast to fossorial amphibians, estivating reed frogs do not become torpid. Reduction in metabolism is therefore rather Iimited so that nitrogenous wastes accumulate faster in these frogs than in fossorial amphibians. This severely aggravates the osmotic problems caused by dehydration. During dry periods total plasma osmolarity greatly increases, mainly due to urea accumulation. Of the total urea accumulated over 42 days of experimental water deprivation, 30\% was produced during the first 7 days. In the next 7 days rise in plasma urea content was negligible. This strong initial increase of urea is seen as a byproduct of elevated amino acid catabolism following the onset of dry conditions. Tbe rise in total plasma osmolarity due to urea accumulation, however, is not totally disadvantageous, but enables fast rehydration when water is available for very short periods only. Voiding of urine and feces eeases once evaporative water loss exceeds 10\% of body weight. Tberefore, during continuous water deprivation, nitrogenous end products are not excreted. After 42 days of water deprivation, bladder fluid was substantially depleted, and urea coneentration in the remaining urine (up to 447 mM) was never greater than in plasma fluid. Feces voided at the end of the dry period after water uptake contained only small amounts of nitrogenous end products. DSF (dry season frogs) seemed not to be uricotelic. Instead, up to 35\% of the total nitrogenous wastes produced over 42 days of water deprivation were deposited in an osmotically inert and nontoxic form in iridophore crystals. The increase in skin purine content averaged 150 µg/mg dry weight. If urea had been the only nitrogenous waste product during an estivation period of 42 days, lethal limits of total osmolarity (about 700 mOsm) would have been reached 10-14 days earlier. Thus iridophores are not only involved in colour change and in reducing heat load by radiation remission, but are also important in osmoregulation during dry periods. The seIective advantages of deposition of guanine rather than uric acid are discussed.},
  subject      = {Biologie},
  language  = {en}
}
@incollection{LinsenmairMikula1988,
  author    = {Linsenmair, Karl Eduard and Mikula, Gerold},
  title     = {Soziale Einfl{\"u}sse},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44469},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {No abstract available},
  language  = {de}
}
@article{LillienSendtnerRohreretal.1988,
  author    = {Lillien, Laura E. and Sendtner, Michael and Rohrer, Hermann and Hughes, Simon M. and Raff, Martin C.},
  title     = {Type-2 Astrocyte Development in Rat Brain Cultures is initiated by a CNTF-like protein produced by type-1 astrocytes},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31708},
  year      = {1988},
  abstract  = {No abstract available},
  language  = {en}
}
@article{LiebertSchneiderSchauliesterMeulen1988,
  author    = {Liebert, U. G. and Schneider-Schaulies, Sibylle and ter Meulen, V.},
  title     = {Measles Virus infections of the central nervous system (CNS) of rats},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-34087},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Masernvirus},
  language  = {en}
}
@article{LausUlrichsMuellerRuchholtz1988,
  author    = {Laus, R. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Carbohydrate-specific human heterophile antibodies in normal human sera that react with xenogeneic cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78271},
  year      = {1988},
  abstract  = {Human heterophile antibodies (HHA) that are present in normal human sera (NHS)play an important role in hyperacute xenograft rejection. The aim of this study was to analyze the occurrence, mode of action and molecular specificity of HHA in NHS that are directed against xenogeneic Iymphocytes (isolated from mouse, rat, guinea pig, rabbit, cattle and pig) and isolated rat pancreatic islets. All sera contained variable amounts of HHA that killed the target cells via the classical complement pathway. The cytotoxic activity of these HHA was specifically inhibited by certain carbohydrates (a-D-melibiose, ß-Iactose, ß-gentiobiose, ß-cellobiose, D-mannose, N-acetyl-ß-D-mannosamine and a-D-rhamnose) and by rat IgM. By means of affinity chromatography with immobilized inhibitors we obtained an antibody preparation of mainly IgG type from NHS (up to 3.5 mg/IO ml serum) that reacted strongly with rat lymphocytes and isolated rat pancreatic islets. Though thus far residual xenospecific antibody activity has remained in the sera even after multiple affinity chromatography, these data suggest that specific elimination of HHA is feasible and that it may be thus possible to overcome a major obstacle to xenotransplantation.},
  subject      = {Immunobiologie},
  language  = {de}
}
@article{LambrechtGmelinRafeineretal.1988,
  author    = {Lambrecht, G. and Gmelin, G. and Rafeiner, K. and Strohmann, C. and Tacke, Reinhold and Mutschler, E.},
  title     = {o-Methoxy-sila-hexocyclium: a new quaternary M\(_1\)-selective muscarinic antagonist},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63862},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{LambrechtFeifelForthetal.1988,
  author    = {Lambrecht, G. and Feifel, R. and Forth, B. and Strohmann, C. and Tacke, Reinhold and Mutschler, E.},
  title     = {p-Fluoro-hexahydro-sila-difenidol: the first M\(_{2\beta}\)-selective muscarinic antagonist},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63872},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@inproceedings{KurtzSchneiderBorkowskietal.1988,
  author    = {Kurtz, Beth and Schneider, Wolfgang and Borkowski, John G. and Carr, Martha and Turner, Lisa A.},
  title     = {Sources of memory and metamemory development: Societal, parental, and educational influences},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50524},
  year      = {1988},
  abstract  = {This project had two goals: (1) to examine the impact of strategy training on memory performance in German and American children, and (2) to search for environmental correlates of individual differences in cognitive processes. Following pretesting, 437 children were divided into training and control groups, with the former receiving training in clustering strategies. Trained children showed sizable strategy maintenance and transfer effects two weeks and six months later. Parents and teachers completed questionnaires about the teaching of strategies and their attributional beliefs about children's academic successes and failures. The differences in strategie behavior and attributions of German and American children were due, in part, to differences in strategy-enriched environments.},
  subject      = {Psychologie},
  language  = {en}
}
@article{KurtzSchneider1988,
  author    = {Kurtz, Beth E. and Schneider, Wolfgang},
  title     = {The effects of age, study time, and importance of text units on strategy use and memory for texts},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87408},
  year      = {1988},
  abstract  = {This study investigated study behavior and recall of a narrative text as a function of the reader's age, study time, and importance level of text units. Fifth graders, seventh graders, young- and older adults were asked to read a fairy tale, and do anything they liked to prepare for verbatim recall. Half of the subjects in each age group were assigned to an immediate recall condition; half were given additional study time. Examination of recall data showed that all subjects showed higher recall of important units in the text than unimportant units. This effect was independent of age and study time condition. Study behaviors varied significantly across age groups and study conditions: while adults underlined or took notes with equal frequency, children preferred note-taking as a study strategy. With additional study time, fifth graders, seventh graders, and older adults increased their strategic behavior; young adults did not.},
  subject      = {Studienzeit},
  language  = {en}
}
@article{KruegerStuckenbergVollrath1988,
  author    = {Kr{\"u}ger, Hans-Peter and Stuckenberg, Annette and Vollrath, Mark},
  title     = {Stability and Variability in Interactive Behavior as Measured by Methods of "Speech Chronemics"},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40908},
  year      = {1988},
  abstract  = {Dyadic interaction is modelled os an adaptive process between personality of the partners involved and the characteristics of the theme. The theme structure and the principles which control the adaptation process are referred to as "syntality". The material of the studies reported are the speech signals of the verbal interaction reduced to an on-off pattern. In a first study individual speech behavior was found to remain stable in dyads even if partners changed. The second study showed the stability of the speech patterns for different interaction themes even if dyads changed. These apparently contradictory results are reconciled by introducing the concept of "adaptive stability". Individual speech behavior does not happen at a stable activity level, but is characterized by a constant relationship (" less" or "more") to the respective activity of the other partner.},
  language  = {en}
}
@article{Krueger1988,
  author    = {Kr{\"u}ger, H.-P.},
  title     = {Psychologische Charakteristika der "D{\"u}ker-Aufgabe" oder "Was ist die Leistung an der Leistung?"},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-41460},
  year      = {1988},
  abstract  = {In den Experimenten H. D{\"u}kers haben die Vpn regelhaft sehr viele sehr einfache hochge{\"u}bte T{\"a}tigkeiten auszuf{\"u}hren. Wird dies durch das Einf{\"u}hren von Zusatzaufgaben kompliziert, kann eine Steigerung der Leistung resultieren (erkl{\"a}rt etwa durch "Reaktive Anspannungssteigerung") oder eine Minderung (wie f{\"u}r das "Unterschwellige Wollen" gezeigt). Eine n{\"a}here Analyse der D{\"u}ker-Aufgabe zeigt, daß die Variable "Arbeitsrhythmus" f{\"u}r diesen Unterschied verantwortlich ist. Wird dieser Rhythmus {\"u}ber eine externe Quelle gegeben oder kann eine Zusatzaufgabe in den vorhandenen Rhythmus integriert werden, resultiert eine Verbesserung. Treten zwei inkompatible Rhythmen in einer Situation auf, resultiert ein drastischer Leistungseinbruch. Diese Systematik wird am pharmakopsychologischen Beispiel einer Statistik {\"u}ber Verkehrsunf{\"a}lle unter Alkoholeinfluß diskutiert.},
  language  = {de}
}
@inproceedings{KreuzerVejnarSchuessleretal.1988,
  author    = {Kreuzer, Hans and Vejnar, Zdenek and Sch{\"u}ssler, Ulrich and Okrusch, Martin and Seidel, Eberhard},
  title     = {K-Ar dating in the Tepl{\´a}-Domazlice zone at the western margin of the Bohemian Massif},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31106},
  year      = {1988},
  abstract  = {K-Ar dating on hornblendes and micas from the Tepla Domazlice zone revealed a pattern of dates which significantly deviates from the mid-Carboniferous to early Permian one that is found in the adjacent low-pressure metamorphic Moldanubian and Saxothuringian. Especially for the Marianske Lazne metabasic complex, confirming early Czech determinations, the dates resemble the early Devonian pattern determined for the Munchberg Gneiss Massif and the Erbendorf-Vohenstrau zone of northeastern Bavaria. This supports the idea that all three units are remnants of a huge' complex which suffered a metamorphic overprint under medium-pressure conditions, probably in the early Devonian. Strong rejuvenation is found in the southern part of the Tepla-Domazlice zone by which micas and even two hornblendes were reset to mid-Carboniferous ages. According to the geological setting, part of the apparently preDevonian dates may be explained by inherited argon from earlier metamorphic and magmatic events, e.g. the high-pressure metamorphism documented in eciogitic relics. However, excess argon, caused by the mid-Carboniferous overprint cannot be excluded.},
  language  = {en}
}
@inproceedings{KreuzerVejnarSchuessleretal.1988,
  author    = {Kreuzer, Hans and Vejnar, Zdenek and Sch{\"u}ssler, Ulrich and Okrusch, Martin and Seidel, Eberhard},
  title     = {K-Ar dating of the last metamorphic events in different tectonic units of the western margin of the Bohemian Massif},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87527},
  year      = {1988},
  abstract  = {K-Ar dating on hornblendes and micas from the Tepl{\"a}Domazlice zone revealed a pattern of dates which significantly deviates from the mid-Carboniferous to early Permian one that is found in the adjacent low-pressure metamorphic Moldanubian and Saxothuringian. Especially for the Mari{\"a}nske L{\"a}zne metabasic complex, confirming early Czech determinations, the dates resemble the early Devonian pattern determined for the M{\"u}nchberg Gneiss Massif and the Erbendorf-Vohenstrauß zone of northeastern Bavaria. This supports the idea that all three units are remnants of a huge complex which suffered a metamorphic overprint under medium-pressure conditions, probably in the early Devonian. Streng rejuvenation is found in the southern part of the Tepl{\"a}-Domailice zone by which micas and even two hornblendes were reset to mid-Carboniferous ages. According to the geological setting, part of the apparently preDevonian dates may be explained by inherited argon from earlier metamorphic and magmatic events, e.g. the high-pressure metamorphism documented in eclogitic relics. However, excess argon, caused by the mid-Carboniferous overprint cannot be excluded.},
  subject      = {Geochemie},
  language  = {en}
}
@book{Kossatz1988,
  author    = {Kossatz, Tilman},
  title     = {Johann Philipp Preuss (1605 - ca. 1687) : ein Beitrag zur Genese barocker Bildkunst in Franken},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-203117},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {Diese Arbeit besch{\"a}ftigt sich mit dem W{\"u}rzburger Bildhauer und Architekten Johann Philipp Preuß (1605 - ca 1687).},
  subject      = {Preiss, Hans Philipp},
  language  = {de}
}
@book{Kossatz1988,
  author    = {Kossatz, Tilman},
  title     = {Johann Philipp Preuss (1605 - ca. 1687) : ein Beitrag zur Genese barocker Bildkunst in Franken},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50645},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {Diese Arbeit besch{\"a}ftigt sich mit dem W{\"u}rzburger Bildhauer und Architekten Johann Philipp Preuß (1605 - ca 1687).},
  subject      = {Preiss, Hans Philipp},
  language  = {de}
}
@article{KlotzLohseSchwabe1988,
  author    = {Klotz, Karl-Norbert and Lohse, M. J. and Schwabe, U.},
  title     = {Chemical modification of A\(_1\) adenosine receptors in rat brain membranes - evidence for histidine in different domains of the ligand binding site},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60295},
  year      = {1988},
  abstract  = {Chemical modification of amino acid residues was used to probe the ligand recognition site of A\(_1\) adenosine receptors from rat brain membranes. The effect of treatment with group·specific reagents on agonist and antagonist radioligand binding was investigated. The histidine-specific reagent diethylpyrocarbonate (DEP) induced a loss of binding of the agonist R-N\(^6\)-[\(^3\)H]phenylisopropyladenosine ([\(^3\)H]PIA), which could be prevented in part by agonists, but not by antagonists. DEP treatment induced also a loss of binding of the antagonist [\(^3\)H]8- cyclopentyl-1 ,3-dipropylxanthine ([\(^3\)H]DPCPX). Antagonists protected A\(_1\) receptors from this inactivation while agonists did not. This result provided evidence for the existence of at least 2 different histidine residues involved in ligand binding. Consistent with a modification of the binding site, DEP did not alter the affinity of [\(^3\)H]DPCPX, but reduced receptor number. From the selective protection of [\(^3\)H] PIA and [\(^3\)H]DPCPX binding from inactivation, it is concluded that agonists and antagonists oocupy different domains at the binding site. Sulfhydryl modifying reagents did not influence antagonist binding, but inhibited agonist binding. This effect is explained by modification of tbe inhibitory guanine nucleotide binding protein. Pyridoxal 5-phosphate inactivated both [\(^3\)H]PIA and [\(^3\)H]DPCPX binding, but the receptors could not be protected from inactivation by ligands. Therefore, no amino group seems to be located at the Iigand binding site. In addition, it was shown that no further amino acids witb polar side chains are present. The absence of bydrophilic amino acids frout the recognition site of the receptor apart from histidine suggests an explanation for the lack of hydrophilic ligands with high affinity for A\(_1\) receptors.},
  subject      = {Toxikologie},
  language  = {en}
}
@article{Klawitter1988,
  author    = {Klawitter, J{\"o}rg},
  title     = {{\"O}kologische Kommunikation: Theorie der Gesellschaft oder Theorie der {\"o}kologischen Gef{\"a}hrdung der Gesellschaft?},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44345},
  year      = {1988},
  abstract  = {No abstract available},
  language  = {de}
}
@article{KekowUlrichsMuellerRuchholtzetal.1988,
  author    = {Kekow, J{\"o}rn and Ulrichs, Karin and M{\"u}ller-Ruchholtz, Wolfgang and Gross, Wolfgang L.},
  title     = {Measurement of rat insulin. Enzyme-linked immunosorbent assay with increased sensitivity, high accuracy, and greater practicability than established radioimmunoassay},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45543},
  year      = {1988},
  abstract  = {Total immunoreactive insulin (IRI) is conventionally determined by radioimmunoassays. IR! measurement in rats can be made more sensitive, accurate, and practical, as demonstrated by a new modified enzyme-linked immunosorbent assay (ELlSA). It is characterized by indirect binding of an anti-insulin antibody by an antiglobulin antibody and uses the principle of competitive saturation. In this ELlSA, IRI can be determined in a wide range of concentrations, corresponding to the standards. The standard curve ranges from 100 to 0.049 ng/mllRI (1 ng/ml - 23.4 JLU/ml - 172 pM rat insulin). The statistical analysis shows between- and within-assay coefficients of variation of :515\%. Diabetes 37:321-26,1988},
  subject      = {Chirurgie},
  language  = {en}
}
@article{HughesLillienRaffetal.1988,
  author    = {Hughes, Simon M. and Lillien, Laura E. and Raff, Martin C. and Rohrer, Hermann and Sendtner, Michael},
  title     = {Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42660},
  year      = {1988},
  abstract  = {We have been studying a population of bipotential glial progenitor cells in the perinatal rat optic nerve and brain in an attempt to understand how cells choose between alternative fates in the developing mammalian central nervous system (CNS). This cell population gives rise initially to oligodendrocytes and then to type-2 astrocytes1 both of which apparently collaborate in sheathing axons in the CNS2,3. In vitro studies suggest that oligodendrocyte differentiation is the constitutive pathway of development for the oligodendrocyte-type-2-astrocyte (O-2A) progenitor cell4,5, whereas type-2 astrocyte differentiation depends on a specific inducing protein6. This protein is present in the developing optic nerve when type-2 astrocytes are differentiating and can induce 0-2A progenitor cells in vitro to express glial fibrillary acidic protein (GFAP)6, a marker of astrocyte differentiation7. Here we show that the type-2-astrocyte-inducing protein is similar or identical to ciliary neutrotrophic factor (CNTF)8,9, which promotes the survival of some types of peripheral neurons in vitro8, including ciliary ganglion neurons8,10. This suggests that CNTF, in addition to its effect on neurons, may be responsible for triggering type-2 astrocyte differentiation in the developing CNS.},
  language  = {en}
}
@inproceedings{HommersEndres1988,
  author    = {Hommers, Wilfried and Endres, Johann},
  title     = {Strafe und Schadensersatz als multivariater Response Komplex},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43895},
  year      = {1988},
  abstract  = {No abstract available},
  language  = {de}
}
@article{Hommers1988,
  author    = {Hommers, Wilfried},
  title     = {Implicit psychological theories in legal thought on sentencing and liability},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47093},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Haftung},
  language  = {en}
}
@misc{Hommers1988,
  author    = {Hommers, Wilfried},
  title     = {Review of "Roskam, E.E., \& Suck, R. (Eds.): Progress in mathematical psychology. Amsterdam: North-Holland, 1987, pp. 538."},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43525},
  year      = {1988},
  abstract  = {No abstract available},
  language  = {en}
}
@article{Hommers1988,
  author    = {Hommers, Wilfried},
  title     = {Die Wirkungen von Entschuldigung und Dritt-Entsch{\"a}digung auf Strafurteile {\"u}ber zwei Schadensarten},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43978},
  year      = {1988},
  abstract  = {Kinder aus 3 Altersgruppen und Erwachsene beurteilten die verdiente Strafe aufgrund von Geschichten {\"u}ber zwei aus Wut erfolgte Sch{\"a}digungen (Sachschaden und K{\"o}rperschaden). Die Geschichten informierten außerdem dar{\"u}ber, ob sich der T{\"a}ter entschuldigte oder ob ein Dritter dem Leidtragenden eine materielle Entsch{\"a}digung gab. Die Dritt-Entsch{\"a}digungsinformation reduzierte die Strafurteile der Vor- und Grundsch{\"u}ler geringf{\"u}gig weniger als die Entschuldigungsinformation. Bei Erwachsenen war der Dritt-Entsch{\"a}digungseffekt jedoch erheblich geringer als der Entschuldigungseffekt. Diese Ergebnisse trafen sowohl auf das mittlere Strafurteil als auch auf den Gebrauch von Strafe zu. Nur die Erwachsenen bestraften den K{\"o}rperschaden mehr als den' Sachschaden.},
  subject      = {Sozialpsychologie},
  language  = {de}
}
@article{Hommers1988,
  author    = {Hommers, Wilfried},
  title     = {Entschuldigung und Entsch{\"a}digung f{\"u}r einen Diebstahl},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44002},
  year      = {1988},
  abstract  = {Kinder aus drei Altersgruppen und Etwachsene beuneilten, wie schlimm jeweils zwei "Diebstahl" -Handlungen von unterschiedlich viel S{\"u}ßigkeitsmengen waren. Die Informationen {\"u}ber die gestohlenen Mengen wurden kombinien dargeboten mit dem Hinweis, daß sich der T{\"a}ter entschuldigte oder nicht bzw. daß ein Dritter dem Leidtragenden den Verlust entsch{\"a}digte oder nicht. Entschuldigung und Schadensh{\"a}he wirkten in allen Altersgruppen und im Vergleich miteinander gleich stark. Bei den beiden j{\"u}ngeren Gruppen wirkten alle drei variierten Geschichtenteile in gleichem Ausmaß auf die Uneile ein. Die Dritt-Entsch{\"a}digung wirkte bei Vorsch{\"u}lern und 7j{\"a}hrigen jedoch st{\"a}rker als bei lOj{\"a}hrigen und Etwachsenen. Die Bedeutung des Auftretens oder Fehlens von Alterstrends f{\"u}r die Entwicklung des moralischen Urteils wird diskutiert.},
  subject      = {P{\"a}dagogische Psychologie},
  language  = {de}
}
@techreport{Hommers1988,
  author    = {Hommers, Wilfried},
  title     = {Recompense as Stimulus and Response: Toward an Exchange of Law and Psychology},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-43743},
  year      = {1988},
  abstract  = {Recompense denotes a more or less complete undoing of a harm which may combine the tWO aspects: compensation for the victim and the apology of the harmdoer. The present empirical research on recompense started with an analysis of the judgmental structures of recompense in legal thought and law, as such analysis has been neglected in prior research. The obtained results on recompense as stimulus and response reinforce the general idea of the present approach of using the framework of law and legal history in the empirical research of cognitive science. Since the traditionahelationship of jurisprudence and psychology is reversed by that research strategy, law and psychology appear to interact mutually, and a more comprehensive concept of legal psychology is implemented.},
  language  = {en}
}
@article{HegmannChristlPetersetal.1988,
  author    = {Hegmann, Joachim and Christl, Manfred and Peters, Karl and Peters, Eva-Maria and Schnering, Hans Georg von},
  title     = {Die Reaktionskaskade von 6-Oxo-5-phenyl-1,3,4-oxadiazin-2-carbons{\"a}ure-methylester und 1,3-Butadienen zu konjugierten und nichtkonjugierten Cyclopentenonen},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58421},
  year      = {1988},
  abstract  = {F{\"u}nfgliedrige Carbocyclen sind Bauelemente zahlreicher NaturstofTe und daher attraktive Syntheseziele. Da bisher kein Syntheseverfahren mit großer Anwendungsbreite bekannt ist, sind neue Methoden willkommen. Wir berichten hier {\"u}ber Umsetzungen des Titelheterocyclus 1 mit l,3-Butadienen 1; diese Reaktionen, obwohl vielstufig, liefern im Eintopfverfahren konjugierte und nichtkonjugierte Cyclopentenone und gestatten auch die F{\"u}nfringanellierung.},
  subject      = {Organische Chemie},
  language  = {de}
}