@article{ZvirblisGorboulevRubtsovetal.1988,
  author    = {Zvirblis, G. S. and Gorboulev, Valentin G. and Rubtsov, P. M. and Chernov, B. K. and Golova, Yu. B. and Pozmogova, G. E. and Skryabin, K. G. and Bayev, A. A.},
  title     = {Genetic engineering of peptide hormones : III. Cloning of cDNA of porcine growth hormone and construction of gene for expression of hormone in bacteria},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-46958},
  year      = {1988},
  abstract  = {Results are presented of cloning cDNA of procine growth hormone, analysis of its primary structure, and creation of a construction capable of expression of this cDNA in Esqheriahia coti cells. It is shown that in the population of mRNA coding porcine growth hormone, heterogeneity is noted which is manifested not only at the level of the nucleotide sequence, but also is reflected in the amino acid sequence of the mature hormone.},
  language  = {en}
}
@article{WirbelauerHofHacker1988,
  author    = {Wirbelauer, J. and Hof, H. and Hacker, J{\"o}rg},
  title     = {Die Wirkung von Desacetylcefotaxin, einem Metaboliten von Cefotaxim, in vitro und auf die experimentelle Infektion mit Escherichia coli},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40348},
  year      = {1988},
  abstract  = {Die MHK-Werte von Desacetylcefotaxim gegen verschiedene, z. T. ampicillinresistente St{\"a}mme von Escherichia coH, die mit Hilfe einer Agardilutionsmethode erhoben wurden, waren h{\"o}her als die von Cefotaxim und Ceftriaxon, jedoch niedriger als die von Cefoxitin. In einem Modell der systemischen Infektion der Maus mit einem plasmidtragenden, betalactamaseproduzierenden Stamm von E. coli f{\"u}hrte die Therapie mit Desacetylcefotaxim zu einer starken Reduktion der Keime pro Leber. Im Vergleich zur Therapie mit Cefotaxim trat die protektive Wirkung aber verlangsamt ein. Desacetylcefotaxim ist also kein unn{\"u}tzes Abbauprodukt von Cefotaxim.},
  language  = {de}
}
@article{WinotoMorbachLeyhausenMuellerRuchholtzetal.1988,
  author    = {Winoto-Morbach, S. and Leyhausen, G. and M{\"u}ller-Ruchholtz, W. and Ulrichs, Karin},
  title     = {The Electromagnetic Separation Principle: A Basis for Human Pancreatic Islet Transplantation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82520},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Allergie},
  language  = {en}
}
@article{Wilhelm1988,
  author    = {Wilhelm, Gernot},
  title     = {K Churritskoj i urartskoj grammatikje},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82984},
  year      = {1988},
  abstract  = {No Abstract available},
  language  = {ru}
}
@incollection{Wilhelm1988,
  author    = {Wilhelm, Gernot},
  title     = {Zur ersten Zeile des Šunaššura-Vertrages},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72337},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {No abstract available.},
  language  = {de}
}
@article{Wilhelm1988,
  author    = {Wilhelm, Gernot},
  title     = {Neue akkadische Gilgameš-Fragmente aus Hattusa},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87718},
  year      = {1988},
  abstract  = {No abstract available.},
  subject      = {Gilgameschichtung},
  language  = {de}
}
@article{Wilhelm1988,
  author    = {Wilhelm, Gernot},
  title     = {Zu den Wollmaßen in Nuzi},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87792},
  year      = {1988},
  abstract  = {no Abstract available},
  subject      = {Nuzi},
  language  = {de}
}
@incollection{Wilhelm1988,
  author    = {Wilhelm, Gernot},
  title     = {Gedanken zur Fr{\"u}hgeschichte der Hurriter und zum hurritisch-urart{\"a}ischen Sprachvergleich},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87728},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {No abstract available.},
  subject      = {Geschichte},
  language  = {de}
}
@incollection{WeinertSchneiderKnopf1988,
  author    = {Weinert, Franz E. and Schneider, Wolfgang and Knopf, Monika},
  title     = {Individual differences in memory development across the life-span},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-70666},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {Experimental research on memory development has typically focused on the description of universal development trends across the life span and the identification of major sources of development within this domain. However, there is a lack of studies investigating the preconditions and effects of interindividual variability within age groups across different memory tasks. Similarly, our knowledge about the stability of interindividual differences across the life span as well as the sources and the amount of intraindividual variability across memory tasks is scarce. In the present chapter, we concentrate on these neglected issues. First, theoretical assumptions concerning the interindividual and intraindividual variability of memory development are discussed. Next, empirical evidence is presented that seems suited to document the importance of these neglected issues. While we try to give a representative account of the literature, the emphasis is on more recent studies of memory development in children and elderly adults conducted in our laboratory. The results demonstrate that age-related changes and individual differences in the knowledge base are particularly important for describing and explaining individual differences in memory develoment. In comparison, the rote of stable individual differences in basic memory capacities in explaining variations in memory development is less clear given tbe conflicting empirical evidence. In the final section of the chapter consequences for future research are discussed.},
  subject      = {Ged{\"a}chtnisbildung},
  language  = {en}
}
@inproceedings{WeinertSchneiderAsendorpfetal.1988,
  author    = {Weinert, Franz E. and Schneider, Wolfgang and Asendorpf, Jens and Helmke, Andreas and Knopf, Monika and Kuhl, Julius and Nunner-Winkler, Gertrud and Strube, Gerhard},
  title     = {Entwicklung im Vorschulalter: Bericht {\"u}ber eine L{\"a}ngsschnittstudie},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86699},
  year      = {1988},
  abstract  = {Dargestellt werden die theoretischen Ziele, das methodische Vorgehen und die ersten Ergebnisse einer Longitudinalstudie zur Genese individueller Kompetenzen (LOGIK) im Vorschulalter. Dabei geht es vor allem um generelle Merkmale und differentielle Verl{\"a}ufe bei der Entwicklung kognitiver, sozialer und motivationaler Kompetenzen.},
  subject      = {Vorschulkind},
  language  = {de}
}
@inproceedings{Wehgartner1988,
  author    = {Wehgartner, Irma},
  title     = {Neue Untersuchungen zur weißgrundigen Lekythenbemalung},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-53807},
  year      = {1988},
  abstract  = {no abstract available},
  subject      = {Lekythenbemalung},
  language  = {de}
}
@article{Wehgartner1988,
  author    = {Wehgartner, Irma},
  title     = {Eine neue "pontische" Oinochoe und {\"U}berlegungen zur Genese ihrer Form},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87561},
  year      = {1988},
  abstract  = {Das Martin-von-Wagner-Museum besitzt eine seit langem bekannte Sammlung bedeutender 'pontischer' Vasen, die vor kurzem durch die Erwerbung einer Oinochoe dieser Gattung sinnvoll erg{\"a}nzt werden konnte (Abb. 30-34. 38. 40-45). Denn obwohl in der 'pontischen' Keramik die Oinochoen nach den Amphoren die h{\"a}ufigste Gef{\"a}ßform sind, war gerade diese Form in der W{\"u}rzburger Sammlung bisher nur durch zwei kleine, atypische Exemplare vertreten gewesen. Die neu erworbene Oinochoe kann dagegen nach ihrer Gr{\"o}ße, ihren Formmerkmalen und ihrer Bemalung als eine typische Vertreterio dieser Form innerhalb der 'pontischen' Gattung gelten.},
  subject      = {Martin-von-Wagner-Museum / Antikenabteilung},
  language  = {de}
}
@article{VollmerEllgring1988,
  author    = {Vollmer, Heinz C. and Ellgring, Johann Heinrich},
  title     = {Die Vorhersage der vorzeitigen Therapiebeendigung bei Drogenabh{\"a}ngigen},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42069},
  year      = {1988},
  abstract  = {In zwei Therapieeinrichtungen zur Drogen-Entw{\"o}hnungsbehandlung wurde bei 194 Dro- , genabh{\"a}ngigen untersucht, inwiefern Anamnesedaten und Pers{\"o}nlichkeits variablen eine Vorhersage der vorzeitigen Therapiebeendigung gestatten. Lediglich eine Variable wies f{\"u}r Patienten beider Behandlungseinrichtungen gleichermaßen prognostische Valenz auf: Patienten mit gerichtlicher Auflage schlossen die Therapie h{\"a}ufiger regul{\"a}r ab als Patienten ohne Auflage. Oie Art der gerichtlichen Auflage oder auch die Dauer der noch ausstehenden Strafzeit korrelierten dagegen nicht mit der Art der Therapiebeendigung. Ansonsten gab es f{\"u}r beide Therapieeinrichtungen und f{\"u}r die verschiedenen Arten der vorzeitigen Beendigung (Entlassung bzw. Abbruch) unterschiedliche, manchmal auch entgegengesetzte, prognostische Kriterien. Ein Patient, der in einer Einrichtung abbruchgef{\"a}hrdet ist, kann in einer anderen Einrichtung gute Chancen haben, die Behandlung regul{\"a}r abzuschließen. Aus der Literatur bekannte Kriterien wie zum Beispiel Alter und Schulbildung zeigten in dieser Studie nur in Abh{\"a}ngigkeit von der Einrichtung prognostische Valenz und dies spezifisch f{\"u}r Abbruch bzw. vorzeitige Entlassung. Andere Pr{\"a}diktoren wie Geschlecht, psychische Auff{\"a}lligkeiten und Depression korrelierten {\"u}berhaupt nicht mit vorzeitiger Therapiebeendigung. Auch Patienten, die zu Beginn der Therapie als gering motiviert einzustufen sind, haben gute Chancen, die Behandlung regul{\"a}r abzuschließen. Auf der Grundlage einer Diskriminanzanalyse der FPI-Items war eine vorzeitige Entlassung besser vorhersag bar als ein Therapieabbruch. Nach den Daten dieser Studie ist zu vermuten, daß bestimmte Kombinationen von Einrichtungs-, Therapeuten- und Patienten variablen einen Einfluß auf die Art der Therapiebeendigung haben.},
  language  = {de}
}
@article{UlrichsMuellerRuchholtz1988,
  author    = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.},
  title     = {Expression of MHC Structures on Immunologically Reactive and Non Reactive Cells in Islets of Langerhans and Other Tissues},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45557},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{ThiryScheerGoessens1988,
  author    = {Thiry, Marc and Scheer, Ulrich and Goessens, Guy},
  title     = {Immunoelectron microscopic study of nucleolar DNA during mitosis in Ehrlich tumour cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40745},
  year      = {1988},
  abstract  = {In order to investigate the DNA localization within Ehrlich tumor cell nucleoli during mitosis, two recent immunocytochemical methods using either an anti-DNA or an anti-bromodeoxyuridine (BrdU) monoclonal antibody have been applied. In both cases, the immunogold labeling has been performed on ultrathin sections of cells embedded either in Lowicryl K4M or in Epon, respectively. Identical results are observed with both immunocytochemical approaches. In the interphase nucleolus, besides the labeling of the perinucleolar chromatin shell and of its intranucleolar invaginations which penetrate into the nucleolar body and often terminate at the fibrillar centers, a few gold particles are also preferentially found towards the peripheral region of the fibrillar centers. In contrast, the dense fibrillar component and the granular component are never labeled. During mitosis, the fibrillar centers persist at the chromosomal nucleolus organizing regions (NOR's) and can be selectively stained by the silver method. However, these metaphase fibrillar centers are no longer decorated by the DNA- or BrdU antibodies. These results indicate that until the end of prophase, rRNA genes are present inside the fibrillar center material, disappear during metaphase and reappear in reconstituting nucleoli during telophase. Thus, fibrillar centers appear to represent structures sui generis, which are populated by rRNA genes only when the nucleolus is functionally active. In segregated nucleoli after actinomycin D treatment, the DNA labeling is exclusively restricted to the perinucleolar chromatin blocks. These findings also suggest that the DNA content of the fibrillar center material varies according to the rRNA transcription level of the cells. The results are discussed in the light of the present knowledge of the functional organization of the nucleolus.},
  subject      = {Cytologie},
  language  = {en}
}
@article{ThiryScheerGoessens1988,
  author    = {Thiry, Marc and Scheer, Ulrich and Goessens, Guy},
  title     = {Localization of DNA within Ehrlich tumour cells nucleoli by immunoelectron microscopy},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39327},
  year      = {1988},
  abstract  = {The distribution of DNA in Ehrlich tumour cell nucleoli was investigated by means of an immunocytochemical approach , involving a monoclonal antibody directed against double- and single-stranded DNA. Immunolabelling was performed . either before or after the embedding process. The postembedding labelling method allows better ultrastructural preservation than the preembedding labelling method. In particular, the various nucleolar components are well preserved and identifiable. In the nucleolus, labelling is particularly concentrated over the perinucleolar chromatin and over its intranucleolar invaginations, which penetrate the nucleolar body and often terminate at the fibrillar centres. In addition, aggregates of gold particles are found in the fibrillar centres, preferentially towards the peripheral regions. By contrast, the dense fibrillar component is completely devoid of labelling. The results seem to indicate that DNA containing the rDNA genes is located in the fibrillar centres, with a preference for the peripheral regions. This finding suggests that transcription of the rDNA genes should occur within the confines of the fibrillar centre, probably close to the boundary region of the surrounding dense fibrillar component. The results are discussed in the light of present knowledge of the functional organization of the nucleolus.},
  language  = {en}
}
@article{TackeRohrAehle1988,
  author    = {Tacke, Reinhold and Rohr-Aehle, R.},
  title     = {Ester des (Hydroxymethyl)[(trimethylsilyl)methyl]silans: Synthese und thermisch induzierte Umlagerung},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63889},
  year      = {1988},
  abstract  = {Die Synthese des (Hydroxymethyl)[(trimethylsilyl)methyl]silans (3) sowie des hiervon abzuleitenden Acetats 4 und Chlorformiats 6 wird beschrieben. 4 und 6 unterliegen einer thermisch induzierten Umwandlung zu den difunktionellen Silanen 5 bzw. 8. Die Umwandlungen 4 -> 5 und 6 -> 8 erfolgen gem{\"a}ß einer Kinetik 1. Ordnung mit Halbwertszeiten von 10.0 bzw. 3.6 h (135 ° C, in C\(_6\)D\(_6\)).},
  subject      = {Anorganische Chemie},
  language  = {de}
}
@article{TackeBecker1988,
  author    = {Tacke, Reinhold and Becker, B.},
  title     = {Synthese und Eigenschaften von (Hydroxymethyl)dimethylgerman und (Hydroxymethyl)diphenylgerman},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63895},
  year      = {1988},
  abstract  = {Die (Hydroxymethyl)diorganylgermane (CH\(_3\))\(_2\)Ge(H)CH\(_2\)OH und (C\(_6\)H\(_5\))\(_2\)Ge(H)CH\(_2\)OH wurden - ausgehend von GeCl\(_4\) - durch eine jeweils vierstufige Synthese mit einer Gesamtausbeute von 15 bzw. 32\% dargestellt (GeCl\(_4\) ---+ Cl\(_3\)GeCH\(_2\)Cl -> R \(_2\)Ge(Cl)CH \(_2\)Cl ->R \(_2\)Ge(OAc)CH\(_2\)OAc--) R \(_2\)Ge(H)CH\(_2\)OH; R = CH\(_3\) bzw. C\(_6\)H\(_5\) ). Die chemische Reaktivit{\"a}t der Germane (CH\(_3\))\(_2\)Ge(H)CH\(_2\)OH und (C\(_6\)H\(_5\))\(_2\)Ge(H)CH\(_2\)OH wird durch deren Ge-H- und 0-H-Bindung bestimmt.},
  subject      = {Anorganische Chemie},
  language  = {de}
}
@article{SyldatkStoffregenWuttkeetal.1988,
  author    = {Syldatk, C. and Stoffregen, A. and Wuttke, F. and Tacke, Reinhold},
  title     = {Enantioselective reduction of acetyldimethylphenylsilane: a screening with thirty strains of microorganisms},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63906},
  year      = {1988},
  abstract  = {Thirty strains of microorganisms (bacteria, yeasts, fungi and green algae) were tested as resting free cells for their ability to transform acetyldimethylphenylsilane (1) enantioselectively into (R)-(1-hydroxyethyl) dimethylphenylsilane [(R)-2]. The biotransformations were monitared by GC (packed OV-17 column), and the enantiomeric purities of the products isolated were determined by HPLC (cellulose triacetate column, UV detection). All microorganisms tested were found to reduce 1 enantioselectively to give (R)-2. Under the test conditions used, the yeast Trigonapsis variabilis (DSM 70714) was found to 1 exhibif the highest specific activity (1.5 mg product x g cell wet mass\(^{-1}\) x min\(^{-1}\) ), whereas the highest enantioselectivities were observed for the bacteria Acinetobacter ca lcoaceticus (ATCC 31012) (>95\% ee), Brevfbacterium species (ATCC 21860) (90\% ee) and Corynebacterium dioxydans (ATCC 21766) (>95\% ee), the yeast Candida humico la (OSM 70067) (90\% ee), the fungus Cunninghame lla e legans (ATCC 26269) (94\% ee), as well as the cyanobacterium Synechococcus leopoliensis (94\% ee).· From the green algae tested, Chlamydomonas reinhardii showed the highest.enantioselectivity (85\% ee).},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{StopperZimmermannNeil1988,
  author    = {Stopper, Helga and Zimmermann, U. and Neil, G. A.},
  title     = {Increased efficiency of transfection of murine hybridoma cells with DNA by electropermeabilization},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63488},
  year      = {1988},
  abstract  = {Dispase-treated murine hybridoma cells (SP2/0-Ag14) were transfected with the G418 resistance gene bearing plasmid pSV2-neo by electropermeabilization with a high degree of efficiency. The cells were subjected to intermittent multiple high-voltage short duration (5 p.s) DC pulses at intervals of 1 min in a weakly conducting medium followed by selection in G418-containing medium. The transfection medium, temperature, pulse duration, and voltage were empirically determined by preliminary electropermeabilization experiments. Increasing the number of pulses resulted in a higher percentage of transfected cells, but a decrease in the number of viable cells, with the optimal transfectant yield resulting when five pulses of 10 kV jcm were administered. This method allows the rapid and efficient injection of DNA into mammalian cells, and permits the rapid production of stable, drug resistant hybridoma celllines for use in subsequent fusion experiments.},
  subject      = {Toxikologie},
  language  = {en}
}