@book{Kossatz1988, author = {Kossatz, Tilman}, title = {Johann Philipp Preuss (1605 - ca. 1687) : ein Beitrag zur Genese barocker Bildkunst in Franken}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-203117}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1988}, abstract = {Diese Arbeit besch{\"a}ftigt sich mit dem W{\"u}rzburger Bildhauer und Architekten Johann Philipp Preuß (1605 - ca 1687).}, subject = {Preiss, Hans Philipp}, language = {de} } @article{HegmannChristlPetersetal.1988, author = {Hegmann, Joachim and Christl, Manfred and Peters, Karl and Peters, Eva-Maria and Schnering, Hans Georg von}, title = {Die Reaktionskaskade von 6-Oxo-5-phenyl-1,3,4-oxadiazin-2-carbons{\"a}ure-methylester und 1,3-Butadienen zu konjugierten und nichtkonjugierten Cyclopentenonen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58421}, year = {1988}, abstract = {F{\"u}nfgliedrige Carbocyclen sind Bauelemente zahlreicher NaturstofTe und daher attraktive Syntheseziele. Da bisher kein Syntheseverfahren mit großer Anwendungsbreite bekannt ist, sind neue Methoden willkommen. Wir berichten hier {\"u}ber Umsetzungen des Titelheterocyclus 1 mit l,3-Butadienen 1; diese Reaktionen, obwohl vielstufig, liefern im Eintopfverfahren konjugierte und nichtkonjugierte Cyclopentenone und gestatten auch die F{\"u}nfringanellierung.}, subject = {Organische Chemie}, language = {de} } @article{AdamWittbrodtTellingetal.1988, author = {Adam, D. and Wittbrodt, J. and Telling, A. and Schartl, Manfred}, title = {RFLP for an EGF-receptor related gene associated with the melanoma oncogene locus of Xiphophorus maculatus}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61822}, year = {1988}, abstract = {No abstract available}, subject = {Physiologische Chemie}, language = {en} } @article{SchartlPeter1988, author = {Schartl, Manfred and Peter, R. U.}, title = {Progressive growth of fish tumors after transplantation into thymus-aplastic (nu/nu) mice}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61833}, year = {1988}, abstract = {No abstract available}, subject = {Physiologische Chemie}, language = {en} } @article{Schartl1988, author = {Schartl, Manfred}, title = {A sex chromosomal restriction-fragment-length marker linked to melanoma-determining Tu loci in Xiphophorus}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61842}, year = {1988}, abstract = {No abstract available}, subject = {Physiologische Chemie}, language = {en} } @article{GesslerBruns1988, author = {Gessler, Manfred and Bruns, Gail A. P.}, title = {Molecular mapping and cloning of the breakpoints of a chromosome 11p14.1-p13 deletion associated with the AGR syndrome}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59264}, year = {1988}, abstract = {Chromosome 11p13 is frequently rearranged in individuals with the WAGR syndrome (Wilms tumor, aniridia, genitourinary anomalies, and mental retardation) or parts of this syndrome. To map the cytogenetic aberrations molecularly, we screened DNA from cell Unes with known WAGR-related chromosome abnormalities for rearrangements with pulsed fleld gel (PFG) analysis using probes deleted from one chromosome 11 homolog of a WAGR patient. The first alteration was detected in a cell line from an individual with aniridia, genitourinary anomalies, mental retardation, and a deletion described as 11p14.1-p13. We have located one breakpoint close to probe HU11-164B and we have cloned both breakpoint sites as well as the junctional fragment. The breakpoints subdivide current intervals on the genetic map, and the probes for both sides will serve as important additional markers for a long-range restriction map of this region. Further characterization and sequencing of the breakpoints may yield insight into the mechanisms by which these deletions occur.}, subject = {Biochemie}, language = {en} } @article{EngelsPeyerimhoff1988, author = {Engels, Bernd and Peyerimhoff, S.D.}, title = {Study of the 1s and 2s shell contributions to the isotropic hyperfine coupling constant in nitrogen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58793}, year = {1988}, abstract = {The istropic part of the hyperfine coupling constant is investigated by means of multireference configuration interaction calculations employing Gaussian basis sets. A detailed study of the 1s and 2s spin polarisation in the nitrogen atom and the NH molecule shows that the structure of the lower-energy space of the unoccupied orbitals is essential for the results. A contraction of the Gaussian basis is possible without loss of accuracy if enough flexibility is retained to describe the main features of the original space of unoccupied functions. Higher than double excitations are found to be non-negligible for the description of α\(_{iso}\).}, subject = {Organische Chemie}, language = {en} } @article{EngelsPeyerimhoffKarnaetal.1988, author = {Engels, Bernd and Peyerimhoff, S.D. and Karna, S.P. and Grein, F.}, title = {The hyperfine coupling constants of the five lowest states of CH : An ab initio MRD-CI study}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58807}, year = {1988}, abstract = {No abstract available}, subject = {Organische Chemie}, language = {en} } @misc{Schneider1988, author = {Schneider, Wolfgang}, title = {Book Reviews: Cognition, Metacognition, and Reading}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62079}, year = {1988}, abstract = {No abstract available}, subject = {Psychologie}, language = {en} } @article{StopperZimmermannNeil1988, author = {Stopper, Helga and Zimmermann, U. and Neil, G. A.}, title = {Increased efficiency of transfection of murine hybridoma cells with DNA by electropermeabilization}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63488}, year = {1988}, abstract = {Dispase-treated murine hybridoma cells (SP2/0-Ag14) were transfected with the G418 resistance gene bearing plasmid pSV2-neo by electropermeabilization with a high degree of efficiency. The cells were subjected to intermittent multiple high-voltage short duration (5 p.s) DC pulses at intervals of 1 min in a weakly conducting medium followed by selection in G418-containing medium. The transfection medium, temperature, pulse duration, and voltage were empirically determined by preliminary electropermeabilization experiments. Increasing the number of pulses resulted in a higher percentage of transfected cells, but a decrease in the number of viable cells, with the optimal transfectant yield resulting when five pulses of 10 kV jcm were administered. This method allows the rapid and efficient injection of DNA into mammalian cells, and permits the rapid production of stable, drug resistant hybridoma celllines for use in subsequent fusion experiments.}, subject = {Toxikologie}, language = {en} } @article{FeuersteinLettsSiren1988, author = {Feuerstein, G. and Letts, G. and Sir{\´e}n, Anna-Leena}, title = {N-Ac-Leukotriene E\(_4\): Unique vascular activity in the conscious rat}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63171}, year = {1988}, abstract = {No abstract available}, subject = {Neurobiologie}, language = {en} } @article{SirenLakeFeuerstein1988, author = {Sir{\´e}n, Anna-Leena and Lake, C. R. and Feuerstein, G.}, title = {Hemodynamic and neural mechanisms of action of thyrotropin releasing hormone in the rat}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63183}, year = {1988}, abstract = {Tbe mechanisms mediating the etl'ects ofthyrotropin-releasing hormone (TRH) on the cardiovascular system were studied in the conscious rat. Intracerebroventricolar (i.c. v.) injection of TRH (8 pmol-80 nmollkg) induced dose-dependent lncreases in mean arterial pressure, heart rate, and cardiac index. Rindquarter blood Oow increased due to vasodilation, while an lncrease in renal and mesenteric vascular resistance caused a decrease in blood Oow in the respective organs. The plasma Ievels of norepinephrine a~d epinephrine were increased by TRH, while there was no change in plasma renin activity or vasopressin. Tbe cardiovascular actions of i.c. v. TRH were not in.fluenced by blockade of the renin-angiotensin system or vasopressin receptors. Tbe ganglion blocker chlorisondamine and the a 1- aod al-adrenoreceptor antagooist phentolamlne (2 mg/kg i.v.) abolished the increase in blood pressure and mesenteric vasoconstriction after i.c. v. TRH. Propranolol (2 mg/kg i. v.) blocked the TRH-ioduced increase in cardiac index, heart rate, and hindquarter blood flow. The hindquarter vasodllatlon lnduced by TRH was also blocked by the selective ß1-adrenocept9r antagonist ICI 188,551 (1 or 2 mg/kg i.v.), while tbe ,8,-adrenoceptor blocker practolol (10 mg/kg i.v.) had no eft'ect on the hindquarter vasodiJation produced by TRH but totally blocked the increase in cardiac Index. In adrenal demedullated rats, the systemic hemodynamic eft'ects ofi.c. v. TRH were dimlnished along with the decrease in renal blood flow and lncrease in renal vascular resistance; however, the iocrease in hfndquarter blood flow was attenuated only in adrenal demedullated rats pretreated with the sympathetlc blocker bretylium. The renal vasoconstriction induced by i.c. v. TRH was not abolished by renal denervation. In sinoaortic debufl'ered rats, the pressor, tachycardic, and mesenteric vasoconstrictor responses to centrally administered TRH were significantly potentiated. Taken together, these data soggest that the putative rieurotransmitter TRH may play a role in central regulation of cardiac functions and organ blood flow distribution through both tbe sympathetic nerves and the adrenal medulla. A pivotal roJe for ß1-adrenoceptors in mediation ofhindquarter vasodilation ls also demonstrated.}, subject = {Neurobiologie}, language = {en} } @article{SirenLettsFeuerstein1988, author = {Sir{\´e}n, Anna-Leena and Letts, G. and Feuerstein, G.}, title = {N-Acetyl-leukotriene E\(_4\) is a potent constrictor of rat mesenteric vessels}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63196}, year = {1988}, abstract = {N-Acetyl-leukotriene E\(_4\) administered to conscious freely moving rats produced a dose-dependent vasoconstriction in the mesenteric vessels which led to profound reduction of blood flow to the gut. Renal and hindquarter blood flow and vascular resistance were not affected even by high doses of N-acetyl-leukotriene E\(_4\) . N-Acetyl-leukotriene E\(_4\) was 10-fold more potent than the thromboxane analog U-46619 and 1000-fold more potent than prostaglandin F\(_{2a}\) but 2-5-fold less potent than leukotriene D\(_4\)/E\(_4\) to induce mesenteric vasoconstriction. These data indicatc that N-acetylleukotriene E\(_4\) is a biologically active metabolite of peptide leukotrienes, and might play a role in cardiovascular derangements mediated by leukotrienes.}, subject = {Neurobiologie}, language = {en} } @article{FeuersteinSiren1988, author = {Feuerstein, G. and Sir{\´e}n, Anna-Leena}, title = {Mesenteric vascular responses to i.v. administration of lipoxin A\(_4\) and lipoxin B\(_4\) in the conscious rat}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63200}, year = {1988}, abstract = {Lipoxin A (LXA\(_4\)) and lipoxin B\(_4\)(LXB\(_4\)) are newly discovered lipoxygenase-interacting products of leukocytes which might have a role in cardiovascular events associated with anaphylaxis. We have tested this possibility by systemic administration of both LXA\(_4\) and LXB\(_4\) to the conscious rat while monitaring systemic and regional hemodynamic changes. LXA\(_4\) and' LXB\(_4\) (l-100 pg/kg) produced dose-dependent constriction of the mesenteric vessels, up to + 123±23\% and +50±9\% for LXA\(_4\)/B\(_4\) , respectively. Dose-related changes were not observed in arterial blood pressure, heart rate, renal (LXB\(_4\)) and hindquarter blood ftow. We suggest that LXA\(_4\) and LXB\(_4\) might affect selective vascular beds, such as the mesenteric vessels, and contribute to variations in blood flow in specific pathophysiological states.}, subject = {Neurobiologie}, language = {en} } @article{Siren1988, author = {Sir{\´e}n, Anna-Leena}, title = {Cardiovascular pharmacology of thyrotropin releasing hormone}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63214}, year = {1988}, subject = {Neurobiologie}, language = {en} } @article{FeuersteinSiren1988, author = {Feuerstein, G. and Sir{\´e}n, Anna-Leena}, title = {Hypothalamic µ-receptors in the cardiovascular control: a review}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63228}, year = {1988}, abstract = {The endogenous opioid system includes three major families of peptides [22): dynorphins (derived from pre-proenkephalin B); endorphins (derived from pre-proopiomelanocortin) and enkephalins (derived from pre-proenkephalin A). Multiple species of opioid peptides are derived from these major precursors and many of them possess potent cardiovascular properties. Multiple forms of opioid receptors have been defined in the central nervous system. Although the relationship of these receptors to the multiple actions of the opioid systems is not weil understood, some predications can be made: in vitro the dynorphin-related peptidesbind preferentially to kappa-opioid receptors; the enkephalins bind preferentially to delta and JL-opioid receptors and while beta-endorphin binds to mu- and delta-, but not to kappa-opioid receptors. While littleis known on the roJe ofthe opioid system in normal cardiovascular regulation, it has become clear that cardiovascular stress situations substantially modify the activity ofthe endogenous opioid system. This review focuses on the mu-opioid system in the hypothalamus with special emphasis on its potential roJe in cardiovascular control of both normal and pathophysiologic states.}, subject = {Neurobiologie}, language = {en} } @article{SirenFeuerstein1988, author = {Sir{\´e}n, Anna-Leena and Feuerstein, G.}, title = {Cardiovascular effects of rat calcitonin gene-related peptide in the conscious rat}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-63236}, year = {1988}, subject = {Neurobiologie}, language = {en} } @article{Hommers1988, author = {Hommers, Wilfried}, title = {Implicit psychological theories in legal thought on sentencing and liability}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47093}, year = {1988}, abstract = {No abstract available}, subject = {Haftung}, language = {en} } @article{SchneiderSchauliesLiebertBaczkoetal.1988, author = {Schneider-Schaulies, Sibylle and Liebert, U. G. and Baczko, K. and ter Meulen, Volker}, title = {Molecular Biological Analyses of Measles Virus Gene Expression in the CNS of Acutely and Persistently Infected Rat Brain Cells}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-34104}, year = {1988}, abstract = {No abstract available}, subject = {Masernvirus}, language = {en} } @article{LiebertSchneiderSchauliesterMeulen1988, author = {Liebert, U. G. and Schneider-Schaulies, Sibylle and ter Meulen, V.}, title = {Measles Virus infections of the central nervous system (CNS) of rats}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-34087}, year = {1988}, abstract = {No abstract available}, subject = {Masernvirus}, language = {en} }