@incollection{Toepfer2011, author = {Toepfer, Regina}, title = {„Feci novum!": Zur Poetik von Thomas Naogeorgs Hamanus-Trag{\"o}die und ihrer deutschen {\"U}bersetzung von Johannes Chryseus}, series = {Aemulatio: Kulturen des Wettstreits in Text und Bild (1450-1620)}, booktitle = {Aemulatio: Kulturen des Wettstreits in Text und Bild (1450-1620)}, publisher = {De Gruyter}, isbn = {978-3-11-026230-8}, doi = {10.1515/9783110262315.449}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-298452}, publisher = {Universit{\"a}t W{\"u}rzburg}, pages = {449-485}, year = {2011}, abstract = {Thomas Naogeorgs 'Hamanus' dokumentiert eindrucksvoll, dass die humanistische Antikenrezeption zur Ausbildung einer eigenen fr{\"u}hneuzeitlichen Poetik f{\"u}hrt. Der 'imitatio veterum' erteilt Naogeorg eine bewusste Absage und entwickelt eine 'Tragoedia nova', indem er mit antiken Gattungskonventionen bricht und komische Elemente in eine Tyrannentrag{\"o}die integriert. Naogeorg begr{\"u}ndet seine konzeptionellen Ver{\"a}nderungen mit dem zeitgen{\"o}ssischen Kontext, in dem sein Werk rezipiert werden soll. Diese Orientierung am Zielpublikum schl{\"a}gt sich ebenso in der deutschen {\"U}bertragung des Johannes Chryseus nieder, der Naogeorgs modifiziertes Trag{\"o}dienkonzept adaptiert, jedoch ohne die poetischen Spezifika zu w{\"u}rdigen.}, subject = {Imitatio}, language = {de} } @incollection{Chetvertak2022, author = {Chetvertak, Іevgeniia}, title = {Cyber aggression in the stance of communicative approach}, series = {Studies in Modern English}, booktitle = {Studies in Modern English}, editor = {Lazebna, Nataliia and Kumar, Dinesh}, publisher = {W{\"u}rzburg University Press}, address = {W{\"u}rzburg}, doi = {10.25972/WUP-978-3-95826-199-0-1}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-296152}, publisher = {W{\"u}rzburg University Press}, pages = {1-9}, year = {2022}, abstract = {The article deals with the notion of internet aggression (cyber aggression). It considers the mentioned term from both psychological and communicative approaches. The paper also provides detailed analyses of the cyber aggression in political discourse. The provided ex-amples are taken from the speeches of politicians during the time of Covid pandemic. The author also identifies several types of cyber aggression.}, language = {en} } @incollection{Kumar2022, author = {Kumar, Dinesh}, title = {A Brief Historical and Present Perspective of ELT in India}, series = {Studies in Modern English}, booktitle = {Studies in Modern English}, editor = {Lazebna, Nataliia and Kumar, Dinesh}, publisher = {W{\"u}rzburg University Press}, address = {W{\"u}rzburg}, doi = {10.25972/WUP-978-3-95826-199-0-11}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-296434}, publisher = {W{\"u}rzburg University Press}, pages = {11-17}, year = {2022}, abstract = {English language is being taught as a second foreign language in India. For most of the learners in India, English still a foreign language or target language. The study of this language is important to fulfill different kinds of academic and professional requirements. Still, there is a big gulf between demand and supply for which the failure of the system is largely responsible as its main emphasis on to adherence to the foreign curriculum. The government tries to impose this curriculum on English teachers, but, in fact, the curriculum is outdated.}, language = {en} } @incollection{KellenRibeiroWengDeToni2022, author = {Kellen Ribeiro Weng, Ana and De Toni, Plinio Marco}, title = {Differences and Similarities between the Fields of Bilingualism and Second Language Acquisition}, series = {Studies in Modern English}, booktitle = {Studies in Modern English}, editor = {Lazebna, Nataliia and Kumar, Dinesh}, publisher = {W{\"u}rzburg University Press}, address = {W{\"u}rzburg}, doi = {10.25972/WUP-978-3-95826-199-0-19}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-296447}, publisher = {W{\"u}rzburg University Press}, pages = {19-24}, year = {2022}, abstract = {No abstract available.}, language = {en} } @incollection{Kushch2022, author = {Kushch, Elina}, title = {The aphoristic potential of presidential rhetoric of G. Bush Jr.}, series = {Studies in Modern English}, booktitle = {Studies in Modern English}, editor = {Lazebna, Nataliia and Kumar, Dinesh}, publisher = {W{\"u}rzburg University Press}, address = {W{\"u}rzburg}, doi = {10.25972/WUP-978-3-95826-199-0-25}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-296456}, publisher = {W{\"u}rzburg University Press}, pages = {25-39}, year = {2022}, abstract = {This research paper concentrates on the analysis of the aphoristic potential of G. W. Bush's presidential rhetoric. Aphorisms are the most ancient laconic forms of expressing original and completed thoughts which reveal the peculiarity of their authors' world perception and worldview. From this perspective, these units can serve as the means of values codification. Repeatability and widespread use of aphorisms in various communications contribute to transmitting the values and ideas between the generations. Political aphorisms, which are a combination of aphoristic expressions from political communication and discourse, play an important role in this process. The authors of these expressions are not only politicians, but also philosophers, historians, writers, celebrities of different nationalities and generations. Presidential rhetoric is an integral and significant part of political discourse. The use of aphorisms as the means of codification of national and common human values in President G. W. Bush's formal addresses and speeches is intentional. It makes them concise and original, influential and convincing. Aphoristic expressions denoting common human values show the ideas and beliefs of their authors, as well as the politician, about life, justice, equality, freedom, faith, family. Aphorisms defining national values become the means of updating concepts of democracy, unity and diversity, freedom and security, success, and opportunity to fulfill one's potential in American society. The distinctive feature of G.W. Bush's rhetoric is the frequent use of aphorisms whose authors are the Founding Fathers.}, language = {en} } @incollection{LazebnaPrykhodko2022, author = {Lazebna, Nataliia and Prykhodko, Anatoliy}, title = {English-language Digital Discourse of Human-Machine Communication}, series = {Studies in Modern English}, booktitle = {Studies in Modern English}, editor = {Lazebna, Nataliia and Kumar, Dinesh}, publisher = {W{\"u}rzburg University Press}, address = {W{\"u}rzburg}, doi = {10.25972/WUP-978-3-95826-199-0-41}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-296468}, publisher = {W{\"u}rzburg University Press}, pages = {41-51}, year = {2022}, abstract = {The paper focuses on digital discourse. This is a speech-intellectual product of innovative information technologies, a phenomenon, which needs further interdisciplinary and linguistic interpretation. The English-language digital discourse shows how linguistic verbal communication is mediated by digits and to what extent these Signum and Verbum unity reigns over the world. The paper analyzes the ways and methods of integrated and differential use of verbal and non-verbal sign systems in the English language as compared to programming languages, considering the types of synchronous changes in the socio-cultural dimension of the sign. This research describes the processes of signs transformation during their functioning in programming languages and in the English language, common and distinctive features in the arrangement of grammatical, lexical-semantic, and graphic means of (natural) English and (artificial) programming languages in their projection on different modes of communication in the system Human ↔ Machine. Programming languages are constituted by verbal means of the English language with additional use of its own semiotic resources, which testifies to their integrative linguistic and mathematical nature. The specific representation of ElDD conveys its reciprocal nature when the English language using its own tools combines them with the elements of the programming languages thus creating an effective toolkit for self-process}, language = {en} } @incollection{LubbunguMoongaMuyunietal.2022, author = {Lubbungu, Jive and Moonga, Ireen and Muyuni, Audrey and Zimba, Samson}, title = {English Language Variation: Creation of Zambian English (ZamEnglish)}, series = {Studies in Modern English}, booktitle = {Studies in Modern English}, editor = {Lazebna, Nataliia and Kumar, Dinesh}, publisher = {W{\"u}rzburg University Press}, address = {W{\"u}rzburg}, doi = {10.25972/WUP-978-3-95826-199-0-53}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-296477}, publisher = {W{\"u}rzburg University Press}, pages = {53-61}, year = {2022}, abstract = {In the present chapter, an attempt has been made to discuss the need to create Zambian English to address English language variations in Zambia. No language in the world can remain the same after interacting with other languages. The present chapter intends to propose and support the idea of using 'Zambian English' for both formal and informal business. Such a measure would create the communicative competence that the majority of the Zambians have always longed for. In Zambia, the purpose of using English language office is to deliberate day to day's business. On the contrary, this has been found to be an obstacle to those who lack principles of command in the language usage, but are able to construct sentences for communicative purposes yet are deprived in international interactions. The views expressed in this chapter are those of the language experts who were engaged in a conver� sation with regard to the possibility of creating what would be known as Zambian English (ZamEnglish).}, language = {en} } @incollection{LutStarenkova2022, author = {Lut, Kateryna and Starenkova, Hanna}, title = {The Relationship between Language, Culture, and Development of Society}, series = {Studies in Modern English}, booktitle = {Studies in Modern English}, editor = {Lazebna, Nataliia and Kumar, Dinesh}, publisher = {W{\"u}rzburg University Press}, address = {W{\"u}rzburg}, doi = {10.25972/WUP-978-3-95826-199-0-63}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-296484}, publisher = {W{\"u}rzburg University Press}, pages = {63-72}, year = {2022}, abstract = {The paper analyses specific characteristics of language that influence the development of culture and societies. The problem of the connection between language and culture has occupied the minds of many famous scientists: some believe that language is a part of the culture as a whole; others think that language is only a form of cultural expression. Undoubtedly, language constitutes a vital component of the cultural background underlying social development. Language is an essential means of communication and interaction. However, language is at the same time sovereign about culture as a whole and can be separate from culture or compared to culture as an equal element (i.e., that language is neither a form nor a component of culture).}, language = {en} } @incollection{Mangada2022, author = {Mangada, Gladys G.}, title = {ESL/EFL in Teaching and Learning Process}, series = {Studies in Modern English}, booktitle = {Studies in Modern English}, editor = {Lazebna, Nataliia and Kumar, Dinesh}, publisher = {W{\"u}rzburg University Press}, address = {W{\"u}rzburg}, doi = {10.25972/WUP-978-3-95826-199-0-73}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-296490}, publisher = {W{\"u}rzburg University Press}, pages = {73-79}, year = {2022}, abstract = {Teaching comprises all types of disciplines and teachers need to look outside the confines of English as a Second Language. The acquisition of knowledge comes in a variety of the learners' educational potential. English as a Second Language in teaching and learning, focuses on active learner's involvement and reduction of coercion. Indeed, Gibran's thoughts remain true that "wisdom leads one to discuss his or her potentials. To realize this, teachers in all educational levels have to portray a less dominant classroom role in accord with the importance of classroom interaction in the teaching learning process. N.A. Flaunders retorted that "in the average classroom someone is talking for two-thirds of the time, two-thirds of the task is direct influence." What does this mean? Students' participation or interaction in the classroom has a significant content to enhance their linguistic competence and its core basis is how to use the language as the most important factor in the classroom. Comprehending the information caters one to establish a fair and well-balanced condition that teachers are facilitators, and the learners are to stay in the frontline. In today's classroom setting, the adoption-adaption of teaching strategies focuses on the learners' ability to have a strong command or fluency of the language. ESL is learned around the globe and the learners' interests are the primary goals in the teaching and learning pro� cess. Colin Blakemore once said that "True knowledge, as Plato argues, must be within us all, and learning consists of solely of discussing what we already know." In an ESL classroom, discovery of knowledge is not a new game. Teachers do perform their tasks and the learners serve not as passive listeners but as active recipients in the transformation-sharing of all the five macro skills namely speaking, reading, writing, listening, and viewing. In fact, if commitment, knowledge of subject-matter for independent learning, and management of learning are packaged in one big box, both the teachers and the learners will operate a mutual process of generating a lively culture and quality of educational life. With the aforementioned views I had experienced in teaching ESL, the teacher's passion for teaching and attitude in dealing with the learners create a strong impact on the learners cognitive, affective, and psychomotor domains.}, language = {en} } @incollection{Maniruzzaman2022, author = {Maniruzzaman, Md.}, title = {Blended Learning in the New Normal: EFL Student and Teacher Perceptions and Reactions}, series = {Studies in Modern English}, booktitle = {Studies in Modern English}, editor = {Lazebna, Nataliia and Kumar, Dinesh}, publisher = {W{\"u}rzburg University Press}, address = {W{\"u}rzburg}, doi = {10.25972/WUP-978-3-95826-199-0-81}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-296508}, publisher = {W{\"u}rzburg University Press}, pages = {81-104}, year = {2022}, abstract = {To reopen educational institutions and return to the classroom, we all need to modify how we act to successfully face the challenges of the new normal resulting from the COVID-19 pandemic and entailing our insights into and the after-effects of the pandemic. More specifically, the new normal might encompass online education we are getting used to during the pandemic and the age-old onsite education as well. Thoughtfully integrated, online and onsite learning combine to create blended learning. However, the pertinent literature reveals that English as a foreign language (EFL) students and teachers differently perceive and react to blended learning in diverse contexts. This study was designed to explore student and teacher perceptions of and reactions to blended learning in the Department of English, Jahangirnagar University in the new normal. Fifty undergraduates of EFL and eight teachers of the department participated in the study. To collect data from them, the Student Questionnaire and the Teacher Questionnaire were used. And the data were processed by applying the SPSS programme module. The findings revealed that the majority of the students and the teachers had mostly positive perceptions of blended learning, although the former did not have sufficient exposure to online learning and the latter lacked adequate insights into online teaching. Further, both the students and the teachers expressed mostly positive reactions to blended learning in the new normal, though the former deemed online examinations inadequately smooth and reliable, and the latter had insufficient experience of online instruction and assessment. The study categorically recommends reforming the curriculum, adopting relevant instructional strategies, developing suitable materials, customizing the assessment, integrating and installing technology, training the teachers, upskilling the students for blended learning, improving the infrastructure, and adjusting the management.}, language = {en} } @incollection{Shtaltovna2022, author = {Shtaltovna, Yuliya}, title = {Linguistic Democratization of the Modern English Language: Functional Parameters of English Youth Slang Neologisms}, series = {Studies in Modern English}, booktitle = {Studies in Modern English}, editor = {Lazebna, Nataliia and Kumar, Dinesh}, publisher = {W{\"u}rzburg University Press}, address = {W{\"u}rzburg}, doi = {10.25972/WUP-978-3-95826-199-0-105}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-296514}, publisher = {W{\"u}rzburg University Press}, pages = {105-115}, year = {2022}, abstract = {No abstract available.}, language = {en} } @incollection{Ali2022, author = {Ali, Zuraina}, title = {A Case Study of the Basic Learners' Struggles in Guessing from Context to Retain Words Learned}, series = {Studies in Modern English}, booktitle = {Studies in Modern English}, editor = {Lazebna, Nataliia and Kumar, Dinesh}, publisher = {W{\"u}rzburg University Press}, address = {W{\"u}rzburg}, doi = {10.25972/WUP-978-3-95826-199-0-117}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-296529}, publisher = {W{\"u}rzburg University Press}, pages = {117-124}, year = {2022}, abstract = {Guessing meaning from context is a challenging strategy for Second Language Learners (SLLs). In using the strategy, research found that poor students or low proficiency learners struggled in their attempts to use it. Mainly, it was reported that it was due to their vocabulary knowledge was limited. In another aspect, retaining vocabulary learnt is also important. Such is essential since learning vocabulary does not mean knowing the definition only. Yet, learners must also be able to use the vocabulary as they engage in language skills such as reading, writing, speaking and listening. The study aims at finding the hindrances faced among poor students' using contextual clues in retaining vocabulary. The study employed a case study to collect data from two basic students studying at a tertiary level. The study found that their hindrances in guessing meaning contexts were due to their being confused in guessing meaning when reading a sentence. Also, it was found that they were not able to find clues since they lacked vocabulary to guess correctly. The study implied that guessing meaning from context required sizeable vocabulary knowledge. Therefore, more training is necessary to assist basic learners in being successful in guessing from contexts.}, language = {en} } @incollection{Toepfer2008, author = {Toepfer, Regina}, title = {Konfessionelle {\"U}bertragungen: Zur volkssprachlichen Rezeption des Kirchenvaters Basilius Magnus im 16. Jahrhundert}, series = {Fr{\"u}hneuzeitliche Konfessionskulturen: 1. Nachwuchstagung des VRG Wittenberg 30.09. - 02.10.2004}, booktitle = {Fr{\"u}hneuzeitliche Konfessionskulturen: 1. Nachwuchstagung des VRG Wittenberg 30.09. - 02.10.2004}, edition = {accepted version}, publisher = {G{\"u}tersloher Verlagshaus}, isbn = {978-3-579-05763-7}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-289729}, publisher = {Universit{\"a}t W{\"u}rzburg}, pages = {119-136}, year = {2008}, abstract = {Wie wirkt sich die Konfessionalisierung auf die religi{\"o}se Lekt{\"u}re in der Volkssprache aus? Diese Frage wird am Beispiel der im deutschen Sprachraum im 16. Jahrhundert erschienenen Drucke des griechischen Kirchenvaters Basilius von C{\"a}sarea untersucht. An der Umdeutung der asketischen Schriften von der traditionell monastischen zu einer allgemein christlichen Lesart wird ebenso die theologische {\"U}berzeugung des {\"U}bersetzers sichtbar wie an den polemisch-apologetischen Bemerkungen mehrerer Textausgaben. Sowohl in der innerreformatorischen als auch in der interkonfessionellen Auseinandersetzung um den wahren Glauben wird Basilius eingesetzt. Im Kampf gegen das Interim soll seine Standhaftigkeit als Vorbild dienen, die Reformation zu verteidigen, wohingegen ihn die katholischen {\"U}bersetzer als Zeugen der Alten Kirche und Beleg f{\"u}r die Rechtgl{\"a}ubigkeit der r{\"o}mischen Kirche anf{\"u}hren. Neben konfessionellen Unterschieden lassen sich auch Gemeinsamkeiten aufzeigen. Vertreter unterschiedlicher Religionsparteien {\"u}bersetzen die Moralhomilien des Kirchenvaters, um Anweisungen f{\"u}r eine christliche Lebensf{\"u}hrung zu erteilen. Aus konfessionskultureller Perspektive betrachtet, pr{\"a}sentieren die deutschen {\"U}bertragungen des Basilius Magnus somit ein breites Spektrum, das von konfessioneller Indoktrination bis hin zu konfessions{\"u}bergreifender Rezeption reicht.}, subject = {Konfessionalisierung}, language = {de} } @incollection{Toepfer2004, author = {Toepfer, Regina}, title = {Von der {\"o}ffentlichen Vorlesung zur Privatlekt{\"u}re: Der Wandel des humanistischen Bestsellers ‚Ad adolescentes' des Basilius Magnus in Verwendung und Verf{\"u}gbarkeit}, series = {Offen und Verborgen: Vorstellungen und Praktiken des {\"O}ffentlichen und Privaten in Mittelalter und Fr{\"u}her Neuzeit}, booktitle = {Offen und Verborgen: Vorstellungen und Praktiken des {\"O}ffentlichen und Privaten in Mittelalter und Fr{\"u}her Neuzeit}, publisher = {Wallstein-Verlag}, isbn = {978-3-89244-823-5}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-287086}, publisher = {Universit{\"a}t W{\"u}rzburg}, pages = {269-285}, year = {2004}, abstract = {Untersucht wird der Gebrauchswandel der Schrift ‚Ad adolescentes' des griechischen Kirchenvaters Basilius von Caesarea und das komplexe Spannungsverh{\"a}ltnis ihrer {\"o}ffentlichen und privaten Rezeption im 15./16. Jahrhundert. Als humanistische Programmschrift war sie Gegenstand {\"o}ffentlicher Vorlesungen an der Universit{\"a}t Leipzig, deren Wirkung jedoch regional begrenzt war. Als Teil der ‚Opera omnia' wurde sie international erh{\"a}ltlich, blieb aber auf die private Lekt{\"u}re angewiesen.}, subject = {Privatheit }, language = {de} } @incollection{Kraft2022, author = {Kraft, Stephan}, title = {Christian Flemmer}, series = {Fr{\"u}he Neuzeit in Deutschland 1620-1720. Literaturwissenschaftliches Verfasserlexikon. Band 3: Feustking, Johann Heinrich - Held, Heinrich}, booktitle = {Fr{\"u}he Neuzeit in Deutschland 1620-1720. Literaturwissenschaftliches Verfasserlexikon. Band 3: Feustking, Johann Heinrich - Held, Heinrich}, publisher = {Walter de Gruyter}, address = {Berlin u. a.}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-282561}, publisher = {Universit{\"a}t W{\"u}rzburg}, pages = {Sp. 66-73}, year = {2022}, abstract = {Kein Abstract verf{\"u}gbar.}, subject = {Flemmer, Christian}, language = {de} } @incollection{Kraft2019, author = {Kraft, Stephan}, title = {Paul Rebhuns Susannenspiel : ein paradigmatischer Fall des protestantischen Bibeldramas}, series = {Reformation und katholische Reform zwischen Kontinuit{\"a}t und Innovation}, booktitle = {Reformation und katholische Reform zwischen Kontinuit{\"a}t und Innovation}, publisher = {K{\"o}nigshausen \& Neumann}, address = {W{\"u}rzburg}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-282522}, publisher = {Universit{\"a}t W{\"u}rzburg}, pages = {305-325}, year = {2019}, abstract = {Kein Abstract verf{\"u}gbar.}, subject = {Rebhun, Paul / Ein geistlich Spiel von der gotfurchtigen und keuschen Frawen Susannen}, language = {de} } @incollection{Kraft2016, author = {Kraft, Stephan}, title = {Vom Umgang mit einem unerh{\"o}rten Ereignis. Andreas Gryphius: "Ermordete Majest{\"a}t. Oder Carolus Stuardus"}, series = {Geschichte in Geschichten}, booktitle = {Geschichte in Geschichten}, publisher = {K{\"o}nigshausen \& Neumann}, address = {W{\"u}rzburg}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-282531}, publisher = {Universit{\"a}t W{\"u}rzburg}, pages = {57-76}, year = {2016}, abstract = {Kein Abstract verf{\"u}gbar.}, language = {de} } @incollection{Kraft2015, author = {Kraft, Stephan}, title = {Auswege aus der Gewissensfalle? : zu August von Kotzebues "Menschenhaß und Reue" und seinem Folgest{\"u}ck "Die edle L{\"u}ge"}, series = {Gewissen}, booktitle = {Gewissen}, publisher = {K{\"o}nighausen\&Neumann}, address = {W{\"u}rzburg}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-282543}, publisher = {Universit{\"a}t W{\"u}rzburg}, pages = {195-208}, year = {2015}, abstract = {Kein Abstract verf{\"u}gbar.}, subject = {Kotzebue, August von / Menschenhaß und Reue}, language = {de} } @incollection{Kraft2011, author = {Kraft, Stephan}, title = {Die N{\"o}te Jupiters : zum Verh{\"a}ltnis von Kom{\"o}die und Souver{\"a}nit{\"a}t bei Plautus, Moli{\`e}re und vor allem Kleist}, series = {Ausnahmezustand der Literatur: neue Lekt{\"u}ren zu Heinrich von Kleist}, booktitle = {Ausnahmezustand der Literatur: neue Lekt{\"u}ren zu Heinrich von Kleist}, publisher = {Wallstein}, address = {G{\"o}ttingen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-282550}, publisher = {Universit{\"a}t W{\"u}rzburg}, pages = {208-225}, year = {2011}, abstract = {Kein Abstract verf{\"u}gbar.}, subject = {Moli{\`e}re / Amphitryon}, language = {de} } @incollection{LiaqatSednevHoebartner2022, author = {Liaqat, Anam and Sednev, Maksim V. and H{\"o}bartner, Claudia}, title = {In Vitro Selection of Deoxyribozymes for the Detection of RNA Modifications}, series = {Ribosome Biogenesis: Methods and Protocols}, booktitle = {Ribosome Biogenesis: Methods and Protocols}, publisher = {Humana Press}, isbn = {978-1-0716-2501-9}, doi = {10.1007/978-1-0716-2501-9_10}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-279208}, publisher = {Universit{\"a}t W{\"u}rzburg}, pages = {167-179}, year = {2022}, abstract = {Deoxyribozymes are artificially evolved DNA molecules with catalytic abilities. RNA-cleaving deoxyribozymes have been recognized as an efficient tool for detection of modifications in target RNAs and provide an alternative to traditional and modern methods for detection of ribose or nucleobase methylation. However, there are only few examples of DNA enzymes that specifically reveal the presence of a certain type of modification, including N6-methyladenosine, and the knowledge about how DNA enzymes recognize modified RNAs is still extremely limited. Therefore, DNA enzymes cannot be easily engineered for the analysis of desired RNA modifications, but are instead identified by in vitro selection from random DNA libraries using synthetic modified RNA substrates. This protocol describes a general in vitro selection stagtegy to evolve new RNA-cleaving DNA enzymes that can efficiently differentiate modified RNA substrates from their unmodified counterpart.}, language = {en} }