@article{CristalliFranchettiGrifantinietal.1988,
  author    = {Cristalli, G. and Franchetti, P. and Grifantini, M. and Vittori, S. and Klotz, Karl-Norbert and Lohse, M. J.},
  title     = {Adenosine receptor agonists: Synthesis and biological evaluation of 1-deaza analogues of adenosine},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-60262},
  year      = {1988},
  abstract  = {In a search for more selective A\(_1\) adenosine receptor agonists, N\(^6\)-[(R)-(-)-1-methyl-2-phenethyl]-1-deazaadenosine (1-deaza-R-PIA, 3a), N\(^6\)-cyclopentyl-1-deazaadenosine (1-deazaCPA, 3b), N\(^6\)-cyclohexyl-l-deazaadenosine (1-deazaCHA, Sc), and the corresponding 2-chloro derivatives 2a-c were synthesized from 5,7-dichloro-3-ß-D-ribofuranosyl-3Himidazo[ 4,5-b]pyridine (1). On the other band, N-ethyl-1'-deoxy-1'-(1-deaza-6-amino-9H-purin-9-yl)-ß-D-ribofuranuronamide (1-deazaNECA, 10) was prepared from 7-nitro-3-ß-D-ribofuranosyl-3H-imidazo[4,5-b]pyridine (4), in an attempt to find a more selective A\(_2\) agonist. The activity of all deaza analogues at adenosine receptors has been determined in adenylate cyclase andin radioligand binding studies. 1-DeazaNECA (10) proved tobe a nonselective agonist at both subtypes of the adenosine receptor. It is about 10-fold less active than NECA but clearly more active than the parent compound 1-deazaadenosine as an inhibitor of platelet aggregation and as a stimulator of cyclic AMP accumulation. The N\(^6\)-substituted 1-deazaadenosines largely retain the A\(_1\) agonist activity of their parent compounds, but lose some of their A\(_2\) agonist activity. This results in A\(_1\)-selective compounds, of which N\(^6\)cyclopentyl- 2-chloro-1-deazaadenosine (1-deaza-2-Cl-CPA, 2b) was identified as the most selective agonist at A\(_1\) adenosine receptors so far known. The activity of all 1-deaza analogues confirms that the presence of the nitrogen atom at position 1 of the purine ring is not critical for A\(_1\) receptor mediated adenosine actions.},
  subject      = {Toxikologie},
  language  = {en}
}
@article{ChristlNusserHerzog1988,
  author    = {Christl, Manfred and Nusser, R. and Herzog, C.},
  title     = {4-Bromoctavalen und zwei (Brommethylen)homobenzvalene anstelle eines erwarteten Bromoctabisvalens},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58409},
  year      = {1988},
  abstract  = {No abstract available.},
  subject      = {Organische Chemie},
  language  = {de}
}
@article{ChristlKraft1988,
  author    = {Christl, Manfred and Kraft, A.},
  title     = {Tricyclo[3.1.1.0\(^{2,6}\)]hexandion (das Valen des o-Benzochinons), Bicyclo[2.1.1]hexan-2,3-dion und Valene eines Chinoxalins, des Phenazins sowie eines Benzophenazins},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58459},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Organische Chemie},
  language  = {de}
}
@article{ChristlKraft1988,
  author    = {Christl, Manfred and Kraft, A.},
  title     = {Tricyclo[3.1.1.0\(^{2,6}\)]hexandion (the Valen of o-Benzochinons), Bicyclo[2.1.1]hexan-2,3-dion and Valene of a Chinoxalins, of Phenazins and of a Benzophenazine},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58462},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Organische Chemie},
  language  = {en}
}
@article{ChristlHennebergerFreund1988,
  author    = {Christl, Manfred and Henneberger, H. and Freund, S.},
  title     = {Halbk{\"a}figverbindungen aus Polycyclen mit einem Bicyclo[1.1.0]butan-System und dazu benachbarter Azobr{\"u}cke durch Radikalreaktionen mit Thiophenol und Bromtrichlormethan},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58440},
  year      = {1988},
  abstract  = {Aus Benzvalen (J) und 3,6-Bis(2-pyridyl)-l,2,4,5-tetrazin wurde das Dihydropyridazin 2c erhalten, das ebenso wie die bekannten Dihydropyridazine 2a, b mit Cyclopropen in die entsprechende Azoverbindung 3 {\"u}berging. Addition von Thiophenol an 3a, c und 5 lieferte unter Beteiligung des Bicyclobutan-Systems und der Azofunktion die Halbk{\"a}figverbindungen 4a, c bzw. 6. Aus der Umsetzung von 7, in dem die Azobr{\"u}cke durch zwei BicycJobutan- Systeme flankiert ist, mit Thiophenol sowie Bromtrichlormethan gingen die Halbk{\"a}figverbindungen 8 bzw. 9 hervor. An diesen ~eaktionen wirken beide Bicyclobutan-Systeme und die Azofunktion mit.},
  subject      = {Organische Chemie},
  language  = {de}
}
@article{ChristlFreundHennebergeretal.1988,
  author    = {Christl, Manfred and Freund, S. and Henneberger, H. and Kraft, A. and Hauck, J. and Irngartinger, H.},
  title     = {Several Polycyclic Valence Isomers of Dimethyl [14]Annulene-1,8-dicarboxylate. Reactivity of a "Nonconjugated" Bis(bicyclo[1.1.0]butane)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58413},
  year      = {1988},
  abstract  = {Diels-Alder reaction of dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate (5) with benzvalene (4), norbornene, and norbornadiene afforded the azo compounds 7 and 8. Theseare derivatives of 2,3-diazabicyclo[2.2.2]oct-2-ene as is azo compound 3, which had been obtained previously from 5 and 2 equiv of benzvalene (4). The photochemical extrusion of nitrogen from 3, 7, and 8 has been studied. Whereas 7 and 8 on direct irradiation in benzene gave rise exclusively to the bicyclo[2.2.0]hexane derivatives 9 and 10, respectively, from 3 in addition to the bicyclo[2.2.0]hexane 11, the diolefin 1l was formed. Diolefin 12 has cisdouble bonds in the nine-membered ring and is fixed in a boat conformation in a manner so that the two bicyclobutane systems approach each other very closely. This geometry suggests the unusual ring opening of the intermediate 1,4-cyclohexanediyl diradical from a boat conformation, which arises by inversion of the primarily generated boat conformation. Sensitized photolysis of 3 as weilasthat of ll produced the saturated isomer 13 of 11 and 12. The proximity of the bicyclobutane systems in 1l causes unprecedented reactions leading to cage compounds. When ll was heated at 90 °C, a rearrangement to the pentacyclic product 10 took place. Utilization of tetradeuteriated substrate ll-d4 supported a pathway with two diradical intermediates. Behaving in a convcntional manncr, bicyclobutane 9 and bis(bicyclobutane) 11 took up 1 and 2 equiv of thiophenol most probably in a radical-chain addition to give the thioethers 28 and 19, respectively. In contrast, bis(bicyclobutane) ll was converted by 1 equiv of thiophenol into cagc compound 30 in a process involving both the strained a systems. Heating at 80 °C subjected 30 to a reversible Copc rearrangement, resulting in a 6:1 mixture of 31 and 30. When it was treated with bromine, 11 was transformed to cage compound 38. This addition is believed to proceed via a cationic intermediate. The structure of cage compound 10 was established by a singlc-crystal X-ray analysis of dialcohol 11 prepared from 20 and methyllithium.},
  subject      = {Organische Chemie},
  language  = {en}
}
@article{BuscheSponholz1988,
  author    = {Busche, Detlef and Sponholz, Barbara},
  title     = {Karsterscheinungen in nichtkarbonatischen Gesteinen der Republik Niger},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-55858},
  year      = {1988},
  abstract  = {Vorgestellt werden L{\"o}sungsformen in karbonatfreien Sandsteinen und Eisenkrusten der {\"o}stlichen Republik Niger. Diese Formen haben eine außerordentlich weite Verbreitung und sind wesentliche Elemente der Landschaft. Beschrieben werden sowohl auf den Dachfl{\"a}chen der s{\"u}dsaharisch/sahelischen Schichtstufen entwickelte Depressionen mit subterraner Entw{\"a}sserung als auch an Wadi h{\"a}ngen und steilen Stufenabschnitten gekappte, horizontal bis schr{\"a}g verlaufende H{\"o}hlen und R{\"o}hren. Viele dieser L{\"o}sungsformen sind zumindest in Resten noch von einer Eisen- oder Kieselkruste ausgekleidet, die u.a. als Indiz f{\"u}r eine Entstehung der Formen im Grundwasserbereich angesehen werden kann. Die Anlage der Karstformen w{\"a}re demnach noch vor die Herauspr{\"a}parierung der Stufen und Inselberge im ausgehenden Terti{\"a}r zu stellen. Die Karstformen in nichtkarbonatischen Gesteinen gleichen bis ins Detail denen des Karbonatkarstes. Eine initiale Formung durch {\"a}olische oder fluviatile Prozesse oder durch Piping kann ausgeschlossen werden.},
  subject      = {Geographie},
  language  = {de}
}
@article{BenaventeSchmidtZachmannHuegleDoerretal.1988,
  author    = {Benavente, Ricardo and Schmidt-Zachmann, Marion S. and H{\"u}gle-D{\"o}rr, B. and Reimer, G. and Rose, K. M. and Scheer, Ulrich},
  title     = {Identification and definition of nucleolus-related fibrillar bodies in micronucleated cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39423},
  year      = {1988},
  abstract  = {Small nucleolus-related bodies which occur in the nUcleoplasm of " micronuclei" lacking nucleolar organizers have been studied by immunofluorescence microscopy. These bodies stained specifically with three different antibodies directed against proteins that are normally associated with the dense fibrillar component of functional nucleoli, but not with antibodies specific for certain proteins of the granular component or the fibrillar centers. Our data show that, in the absence of rRNA genes, the various constituent proteins characteristic of the dense fibrillar component spontaneously assemble into spherical entities but that the subsequent fusion of these bodies into larger structures is prevented in these micronuclei. The similarity between these nucleolus-related bodies of micronuclei and the prenucleolar bodies characteristic of early stages of nucleologenesis during mitotic telophase is discussed.},
  language  = {en}
}
@article{BenaventeReimerRoseetal.1988,
  author    = {Benavente, Ricardo and Reimer, Georg and Rose, Kathleen M. and H{\"u}gle-D{\"o}rr, Barbara and Scheer, Ulrich},
  title     = {Nucleolar changes after microinjection of antibodies to RNA polymerase I into the nucleus of mammalian cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-40666},
  year      = {1988},
  abstract  = {After microinjection of antibodies against RNA polymerase I into the nuclei of cultured rat kangaroo (PtKz) and rat (RVF-SMC) cells alterations in nucleolar structure and composition were observed. These were detected by electron microscopy and double-label immunofluorescence microscopy using antibodies to proteins representative of the three major components of the nucleolus. The microinjected antibodies produced a progressive loss of the material of the dense fibrillar component (DFC) from the nucleoli which, at 4 h after injection, were transformed into bodies with purely granular component (GC) structure with attached fibrillar centers (FCs). Concomitantly, numerous extranucleolar aggregates appeared in the nucleoplasm which morphologically resembled fragments of the DFC and contained a protein (fibrillarin) diagnostic for this nucleolar structure. These observations indicate that the topological distribution of the material constituting the DFC can be experimentally influenced in interphase cells, apparently by modulating the transcriptional activity of the rRNA genes. These effects are different from nucleolar lesions induced by inhibitory drugs such as actinomycin D-dependent "nucleolar segregation". The structural alterations induced by antibodies to RNA polymerase I resemble, however, the initial events of nucleolar disintegration during mitotic prophase.},
  language  = {en}
}
@article{AdamWittbrodtTellingetal.1988,
  author    = {Adam, D. and Wittbrodt, J. and Telling, A. and Schartl, Manfred},
  title     = {RFLP for an EGF-receptor related gene associated with the melanoma oncogene locus of Xiphophorus maculatus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61822},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Physiologische Chemie},
  language  = {en}
}
@book{OPUS4-4845,
  title     = {Verantwortung in Umwelt und Sch{\"o}pfung : eine Unterrichtsreihe f{\"u}r den Religionsunterricht der 10. Jahrgangsstufe an Gymnasien und Realschulen},
  organization    = {Studiengruppe Entwicklungsprobleme der Industriegesellschaft},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-56873},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1988},
  abstract  = {No abstract available},
  subject      = {Religionsunterricht},
  language  = {de}
}
@misc{OPUS4-3485,
  title     = {Jahresbericht 1987},
  organization    = {Universit{\"a}tsbibliothek W{\"u}rzburg},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-42319},
  year      = {1988},
  abstract  = {Die Entwicklung der Universit{\"a}tsbibliothek W{\"u}rzburg im Jahr 1987.},
  subject      = {W{\"u}rzburg},
  language  = {de}
}