@article{BraeuningerKleinschnitzStoll2010,
  author    = {Braeuninger, Stefan and Kleinschnitz, C. and Stoll, G.},
  title     = {Interleukin-18 does not influence infarct volume or functional outcome in the early stage after transient focal brain ischemia in mice},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-68141},
  year      = {2010},
  abstract  = {Interleukin-18 (IL-18) is a proinflammatory cytokine of the interleukin-1 family which is upregulated after cerebral ischemia. The functional role of IL-18 in cerebral ischemia is unknown. In the present study, we compared infarct size in IL-18 knock-out and wild-type mice 24 hours and 48 hours after 1-hour transient middle cerebral artery occlusion (tMCAO). Moreover, the functional outcome was evaluated in a modified Bederson score, foot fault test and grip test. There were no significant differences in infarct size or functional outcome tests between wild-type and IL-18 knock-out mice. These data indicate that the early inflammatory response to cerebral ischemia does not involve IL-18, in contrast to other interleukin-1 family members such as interleukin-1.},
  subject      = {Interleukin-18},
  language  = {en}
}