@article{NeuederAndreattaPauli2019,
  author    = {Neueder, Dorothea and Andreatta, Marta and Pauli, Paul},
  title     = {Contextual fear conditioning and fear generalization in individuals with panic attacks},
  series = {Frontiers in Behavioral Neuroscience},
  volume    = {13},
  journal   = {Frontiers in Behavioral Neuroscience},
  doi       = {10.3389/fnbeh.2019.00152},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-201318},
  pages     = {152},
  year      = {2019},
  abstract  = {Context conditioning is characterized by unpredictable threat and its generalization may constitute risk factors for panic disorder (PD). Therefore, we examined differences between individuals with panic attacks (PA; N = 21) and healthy controls (HC, N = 22) in contextual learning and context generalization using a virtual reality (VR) paradigm. Successful context conditioning was indicated in both groups by higher arousal, anxiety and contingency ratings, and increased startle responses and skin conductance levels (SCLs) in an anxiety context (CTX+) where an aversive unconditioned stimulus (US) occurred unpredictably vs. a safety context (CTX-). PA compared to HC exhibited increased differential responding to CTX+ vs. CTX- and overgeneralization of contextual anxiety on an evaluative verbal level, but not on a physiological level. We conclude that increased contextual conditioning and contextual generalization may constitute risk factors for PD or agoraphobia contributing to the characteristic avoidance of anxiety contexts and withdrawal to safety contexts and that evaluative cognitive process may play a major role.},
  language  = {en}
}
@article{ManishNueckelMuehlbergeretal.2013,
  author    = {Manish, Asthana and Nueckel, Katharina and M{\"u}hlberger, Andreas and Neueder, Dorothea and Polak, Thomas and Domschke, Katharina and Deckert, J{\"u}rgen and Herrmann, Martin J.},
  title     = {Effects of transcranial direct current stimulation on consolidation of fear memory},
  series = {Frontiers in Neuropsychiatric Imaging and Stimulation},
  journal   = {Frontiers in Neuropsychiatric Imaging and Stimulation},
  doi       = {10.3389/fpsyt.2013.00107},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-97294},
  year      = {2013},
  abstract  = {It has been shown that applying transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) influences declarative memory processes. This study investigates the efficacy of tDCS on emotional memory consolidation, especially experimental fear conditioning. We applied an auditory fear-conditioning paradigm, in which two differently colored squares (blue and yellow) were presented as conditioned stimuli (CS) and an auditory stimulus as unconditioned stimulus (UCS). Sixty-nine participants were randomly assigned into three groups: anodal, cathodal, and sham stimulation. The participants of the two active groups (i.e., anodal and cathodal) received tDCS over the left DLPFC for 12 min after fear conditioning. The effect of fear conditioning and consolidation (24 h later) was measured by assessing the skin conductance response (SCR) to the CS. The results provide evidence that cathodal stimulation of the left DLPFC leads to an inhibitory effect on fear memory consolidation compared to anodal and sham stimulation, as indicated by decreased SCRs to CS+ presentation during extinction training at day 2. In conclusion, current work suggests that cathodal stimulation interferes with processes of fear memory consolidation.},
  language  = {en}
}